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1.8.4.12: peptide-methionine (R)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (R)-S-oxide reductase, go to the full flat file.

Word Map on EC 1.8.4.12

Reaction

L-methionine (R)-sulfoxide
+
thioredoxin
=
L-methionine
 +
thioredoxin disulfide
 +
H2O

Synonyms

1-Cys methionine sulfoxide reductase B, 1-Cys MSRB, CBS-1, CBS1, cysteine-containing methionine-R-sulfoxide reductase, LOC100305558, LOC100798757, methionine sulfoxide reductase, methionine sulfoxide reductase B, methionine sulfoxide reductase B1, methionine sulfoxide reductase B2, methionine sulfoxide reductase B3, methionine sulfoxide reductase B8, methionine sulfoxide reductase MsrB3, methionine sulfoxide reductases B, methionine sulfoxide reductases B2, methionine sulphoxide reductase, methionine-R-sulfoxide reductase, methionine-R-sulfoxide reductase B, methionine-R-sulfoxide reductase B2, MetO reductase, More, MSR, MsrA, MsrA/B, MsrA/MsrB, msrAB, MsrABTk, MsrB, MSRB1, MsrB2, MsrB3, MsrB3A, MSRB4, MsrB5, MsrB7, MsrB8, MsrBA, Mxr2, NtMsrB2, OsMSRB5, PaMsrB1, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase type B, PilB, PilB protein, PMSR, Sel-X, selenocysteine-containing methionine-R-sulfoxide reductase, selenoprotein R, SelR, sulindac reductase, TbmsrB, TCDM_06423, YeaA

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.12 peptide-methionine (R)-S-oxide reductase

Expression

Expression on EC 1.8.4.12 - peptide-methionine (R)-S-oxide reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme is constitutively expressed
expression is downregulated when exposed to phoxime
expression is upregulated by abscisic acid, salt, cold, and methyl viologen stress within 24 h of treatment
-
expression is upregulated by oxidative stresses, including 4°C, 16°C, 25°C, and 42°C, ultraviolet light, H2O2, CdCl2, HgCl2, paraquat, imidacloprid, and cyhalothrin
in seedling shoots, isoform MSRB5 is expressed in response to drought conditions. Under salt stress, MSRB5 is upregulated in seedling roots
isoforms MsrB7 and MsrB8 are induced by oxidative stress
-
lipopolysaccharide induces expression of MsrB1
MsrB2 is down-regulated upon inoculation with either incompatible or compatible pathogens. The expression of MsrB2 is suppressed by treatment with 0.1 mM methyl jasmonate, 5 mM salicylic acid, and 5 mM ethephone
OsMSRB5 is induced by the excess copper (Cu) treatment
sRNA RyhB is a direct regulator of the MsrB. RyhB down-regulates MsrB transcripts along with Hfq and RNaseE proteins. Mutations in the ryhB, fur, hfq, or RNaseE-encoded genes result in iron-insensitive expression of MsrB. RyhB pairing to msrB mRNA prevents efficient ribosome binding and thereby inhibits translation initiation. Both RyhB-pairing sites are required to decrease msrB expression
under salt stress, MsrB1 is downregulated in seedling shoots