1.8.1.B1: thioredoxin glutathione reductase
This is an abbreviated version!
For detailed information about thioredoxin glutathione reductase, go to the full flat file.
Word Map on EC 1.8.1.B1
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1.8.1.B1
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schistosoma
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schistosomiasis
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worm
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mansoni
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praziquantel
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glutaredoxin
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selenocysteine
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antischistosomal
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gssg
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auranofin
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platyhelminth
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flatworm
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dtnb
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fluke
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sjtgr
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fasciola
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oxadiazole
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cysticerci
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hysteretic
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medicine
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taenia
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trematode
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echinococcus
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granulosus
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schistosomicidal
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crassiceps
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gigantica
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selenocysteine-containing
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furoxans
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analysis
- 1.8.1.B1
- schistosoma
- schistosomiasis
- worm
- mansoni
- praziquantel
- glutaredoxin
- selenocysteine
-
antischistosomal
- gssg
- auranofin
-
platyhelminth
- flatworm
- dtnb
- fluke
-
sjtgr
- fasciola
-
oxadiazole
- cysticerci
-
hysteretic
- medicine
-
taenia
-
trematode
-
echinococcus
- granulosus
-
schistosomicidal
- crassiceps
- gigantica
-
selenocysteine-containing
- furoxans
- analysis
Reaction
Synonyms
cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase
ECTree
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Substrates Products
Substrates Products on EC 1.8.1.B1 - thioredoxin glutathione reductase
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REACTION DIAGRAM
5,5'-dithio-bis(2-nitrobenzoic acid) + NADPH + H+
5'-thionitrobenzoic acid + NADP+
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
2-nitro-5-thiobenzoate + NADP+
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-
-
?
beta-hydroxyethyl disulfide + NADPH + H+
2 2-sulfanylethan-1-ol + NADP+
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-
-
-
?
cytosolic thioredoxin + NADP+
cytosolic thioredoxin disulfide + NADPH
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-
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r
glutathione-hydroxyethyl disulfide + NADPH + H+
glutathione + 2-sulfanylethan-1-ol + NADP+
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-
-
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?
mitochondrial thioredoxin + NADP+
mitochondrial thioredoxin disulfide + NADPH
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-
-
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r
thioredoxin disulfide + NADPH
thioredoxin + NADP+
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absolute specificity for NADPH as electron donor
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-
?
2-nitro-5-thiobenzoate + NADP+
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-
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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-
-
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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-
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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-
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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-
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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-
-
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
absolute specificity for NADPH as electron donor
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-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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?
2 glutathione + NADP+
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?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
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enzyme displays hysteretic behavior
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?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
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the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites
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?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
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?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
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?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
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the enzyme of the parasite essential for the survival of schistosomes in the mammalian host
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?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
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the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion
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?
GSSG + NADPH + H+
glutathione + NADP+
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absolute specificity for NADPH as electron donor
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?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
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?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
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?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
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?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
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?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
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?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
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-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
the enzyme of the parasite essential for the survival of schistosomes in the mammalian host
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-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion
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-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
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Escherichia coli thioredoxin disulfide
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?
?
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the glutathione reductase activity of TGR exhibits hysteretic behavior regulated by the [GSSG]/[GSH] ratio. This behavior is associated with glutathionylation by GSSG and abolished by deglutathionylation
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additional information
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TGR promotes isomerization of disulfide bonds formed between glutathione peroxidase 4 and certain sperm proteins, generating a 46-kDa species containing glutathione peroxidase 4 from high molecular weight nonspecific cross-links
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additional information
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the parasite-specific enzyme thioredoxin glutathione reductase is a component of the defense system
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