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1.8.1.B1: thioredoxin glutathione reductase

This is an abbreviated version!
For detailed information about thioredoxin glutathione reductase, go to the full flat file.

Word Map on EC 1.8.1.B1

Reaction

glutathione disulfide
+
NADPH
 +
H+
= 2 glutathione +
NADP+

Synonyms

cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.B1 thioredoxin glutathione reductase

Reference

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Reference on EC 1.8.1.B1 - thioredoxin glutathione reductase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Su, D.; Novoselov, S.V.; Sun, Q.A.; Moustafa, M.E.; Zhou, Y.; Oko, R.; Hatfield, D.L.; Gladyshev, V.N.
Mammalian selenoprotein thioredoxin/glutathione reductase: roles in disulfide bond formation and sperm maturation
J. Biol. Chem.
280
26491-26498
2005
Mus musculus
Manually annotated by BRENDA team
Rendon, J.L.; del Arenal, I.P.; Guevara-Flores, A.; Uribe, A.; Plancarte, A.; Mendoza-Hernandez, G.
Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci)
Mol. Biochem. Parasitol.
133
61-69
2004
Taenia crassiceps
Manually annotated by BRENDA team
Lea, W.A.; Jadhav, A.; Rai, G.; Sayed, A.A.; Cass, C.L.; Inglese, J.; Williams, D.L.; Austin, C.P.; Simeonov, A.
A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase
Assay Drug Dev. Technol.
6
551-555
2008
Schistosoma mansoni
Manually annotated by BRENDA team
Sun, Q.A.; Su, D.; Novoselov, S.V.; Carlson, B.A.; Hatfield, D.L.; Gladyshev, V.N.
Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase
Biochemistry
44
14528-14537
2005
Bos taurus, Danio rerio, Gallus gallus, Homo sapiens, Mus musculus, no activity in Caenorhabditis elegans, no activity in Canis familiaris, no activity in Drosophila melanogaster, no activity in Sus scrofa, Pan troglodytes, Rattus norvegicus, Takifugu rubripes, Xenopus laevis, Tetraodon nigroviridis
Manually annotated by BRENDA team
Huang, H.H.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.
Acid-base catalysis in the mechanism of thioredoxin reductase from Drosophila melanogaster
Biochemistry
47
1721-1731
2008
Drosophila melanogaster
Manually annotated by BRENDA team
Agorio, A.; Chalar, C.; Cardozo, S.; Salinas, G.
Alternative mRNAs arising from trans-splicing code for mitochondrial and cytosolic variants of Echinococcus granulosus thioredoxin glutathione reductase
J. Biol. Chem.
278
12920-12928
2003
Echinococcus granulosus (Q869D6), Echinococcus granulosus (Q869D7), Echinococcus granulosus
Manually annotated by BRENDA team
Jurado, J.; Prieto-Alamo, M.J.; Madrid-Risquez, J.; Pueyo, C.
Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouse
J. Biol. Chem.
278
45546-45554
2003
Mus musculus (Q99MD6)
Manually annotated by BRENDA team
Bonilla, M.; Denicola, A.; Novoselov, S.V.; Turanov, A.A.; Protasio, A.; Izmendi, D.; Gladyshev, V.N.; Salinas, G.
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione
J. Biol. Chem.
283
17898-17907
2008
Echinococcus granulosus
Manually annotated by BRENDA team
Alger, H.M.; Williams, D.L.
The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase
Mol. Biochem. Parasitol.
121
129-139
2002
Schistosoma mansoni (Q962Y6), Schistosoma mansoni
Manually annotated by BRENDA team
Sayed, A.A.; Simeonov, A.; Thomas, C.J.; Inglese, J.; Austin, C.P.; Williams, D.L.
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
Nat. Med.
14
407-412
2008
Schistosoma mansoni
Manually annotated by BRENDA team
Kuntz Angela, N.; Davioud-Charvet, E.; Sayed Ahmed, A.; Califf Lindsay, L.; Dessolin, J.; Arner Elias, S.J.; Williams David, L.
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target
PLoS Med.
4
e206
2007
Schistosoma mansoni
Manually annotated by BRENDA team
Simeonov, A.; Jadhav, A.; Sayed, A.A.; Wang, Y.; Nelson, M.E.; Thomas, C.J.; Inglese, J.; Williams, D.L.; Austin, C.P.
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade
PLoS Negl. Trop. Dis.
2
e127
2008
Schistosoma mansoni
Manually annotated by BRENDA team
Angelucci, F.; Miele, A.E.; Boumis, G.; Dimastrogiovanni, D.; Brunori, M.; Bellelli, A.
Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase
Proteins
72
936-945
2008
Schistosoma mansoni
Manually annotated by BRENDA team
Salinas, G.; Selkirk, M.E.; Chalar, C.; Maizels, R.M.; Fernandez, C.
Linked thioredoxin-glutathione systems in platyhelminths
Trends Parasitol.
20
340-346
2004
Echinococcus granulosus (Q869D6), Echinococcus granulosus (Q869D7), Schistosoma mansoni (Q962Y6)
Manually annotated by BRENDA team
Huang, H.H.; Day, L.; Cass, C.L.; Ballou, D.P.; Williams, C.H.; Williams, D.L.
Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni
Biochemistry
50
5870-5882
2011
Schistosoma mansoni
Manually annotated by BRENDA team
Prast-Nielsen, S.; Huang, H.H.; Williams, D.L.
Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases
Biochim. Biophys. Acta
1810
1262-1271
2011
Schistosoma mansoni (Q962Y6)
Manually annotated by BRENDA team
Cao, Y.; Zhao, B.; Han, Y.; Zhang, J.; Li, X.; Qiu, C.; Wu, X.; Hong, Y.; Ai, D.; Lin, J.; Fu, Z.
Gene gun bombardment with DNA-coated golden particles enhanced the protective effect of a DNA vaccine based on thioredoxin glutathione reductase of Schistosoma japonicum
BioMed Res. Int.
2013
952416
2013
Schistosoma japonicum
Manually annotated by BRENDA team
Maggioli, G.; Silveira, F.; Martin-Alonso, J.M.; Salinas, G.; Carmona, C.; Parra, F.
A recombinant thioredoxin-glutathione reductase from Fasciola hepatica induces a protective response in rabbits
Exp. Parasitol.
129
323-330
2011
Fasciola hepatica (A8E0R8), Fasciola hepatica
Manually annotated by BRENDA team
Bonilla, M.; Denicola, A.; Marino, S.M.; Gladyshev, V.N.; Salinas, G.
Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation
J. Biol. Chem.
286
4959-4967
2011
Echinococcus granulosus
Manually annotated by BRENDA team
Guevara-Flores, A.; Del Arenal, I.P.; Mendoza-Hernandez, G.; Pardo, J.P.; Flores-Herrera, O.; Rendon, J.L.
Mitochondrial thioredoxin-glutathione reductase from larval Taenia crassiceps (Cysticerci)
J. Parasitol. Res.
2010
2010
2010
Taenia crassiceps
Manually annotated by BRENDA team
Han, Y.; Zhang, M.; Hong, Y.; Zhu, Z.; Li, D.; Li, X.; Fu, Z.; Lin, J.
Characterization of thioredoxin glutathione reductase in Schiotosoma japonicum
Parasitol. Int.
61
475-480
2012
Schistosoma japonicum (B5THG7), Schistosoma japonicum
Manually annotated by BRENDA team
Song, L.; Li, J.; Xie, S.; Qian, C.; Wang, J.; Zhang, W.; Yin, X.; Hua, Z.; Yu, C.
Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum
PLoS ONE
7
e31456
2012
Schistosoma japonicum
Manually annotated by BRENDA team
Dobrovolska, O.; Shumilina, E.; Gladyshev, V.N.; Dikiy, A.
Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase
PLoS ONE
7
e52914
2012
Mus musculus (Q99MD6), Mus musculus
Manually annotated by BRENDA team
Li, Y.; Wu, Q.; Peng, Y.; Huang, F.; Li, X.; Chen, L.; Shi, D.; Zhou, X.; Fan, X.
Expression, crystallization and preliminary X-ray diffraction analysis of thioredoxin glutathione reductase from Schistosoma japonicum in complex with FAD
Acta Crystallogr. Sect. F
70
92-96
2014
Schistosoma japonicum (Q5DE05), Schistosoma japonicum
Manually annotated by BRENDA team
Wu, Z.; Hou, Y.; Dai, Z.; Hu, C.A.; Wu, G.
Metabolism, nutrition, and redox signaling of hydroxyproline
Antioxid. Redox Signal.
30
674-682
2017
Echinococcus granulosus
Manually annotated by BRENDA team
Plancarte, A.; Nava, G.
Purification and kinetic analysis of cytosolic and mitochondrial thioredoxin glutathione reductase extracted from Taenia solium cysticerci
Exp. Parasitol.
149
65-73
2015
Taenia solium
Manually annotated by BRENDA team
Li, T.; Ziniel, P.D.; He, P.Q.; Kommer, V.P.; Crowther, G.J.; He, M.; Liu, Q.; Van Voorhis, W.C.; Williams, D.L.; Wang, M.W.
High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis
Infect. Dis. Poverty
4
40
2015
Schistosoma mansoni
Manually annotated by BRENDA team
Gupta, A.; Kesherwani, M.; Velmurugan, D.; Tripathi, T.
Fasciola gigantica thioredoxin glutathione reductase Biochemical properties and structural modeling
Int. J. Biol. Macromol.
89
152-160
2016
Fasciola gigantica
Manually annotated by BRENDA team
El Gendy, A.; Rabie, I.; El Deeb, S.; El Amir, A.
Importance of Schistosoma mansoni thioredoxin glutathione reductase 1- evaluation of its role in schistosomiasis diagnosis in human
J. Med. Sci.
13
635-646
2013
Schistosoma mansoni
-
Manually annotated by BRENDA team
Saiz, C.; Castillo, V.; Fontan, P.; Bonilla, M.; Salinas, G.; Rodriguez-Haralambides, A.; Mahler, S.G.
Discovering Echinococcus granulosus thioredoxin glutathione reductase inhibitors through site-specific dynamic combinatorial chemistry
Mol. Divers.
18
1-12
2014
Echinococcus granulosus (F8QQF4), Echinococcus granulosus
Manually annotated by BRENDA team
Huang, J.; Hua, W.; Li, J.; Hua, Z.
Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase
Mol. Med. Rep.
12
5787-5795
2015
Schistosoma japonicum (B5THG7), Schistosoma japonicum, Schistosoma mansoni (Q962Y6), Schistosoma mansoni
Manually annotated by BRENDA team
Martinez-Gonzalez, J.J.; Guevara-Flores, A.; Rendon, J.L.; Sosa-Peinado, A.; Del Arenal Mena, I.P.
Purification and characterization of Taenia crassiceps cysticerci thioredoxin insight into thioredoxin-glutathione-reductase (TGR) substrate recognition
Parasitol. Int.
64
194-201
2015
Taenia crassiceps
Manually annotated by BRENDA team
Changklungmoa, N.; Kueakhai, P.; Sangpairoj, K.; Chaichanasak, P.; Jaikua, W.; Riengrojpitak, S.; Sobhon, P.; Chaithirayanon, K.
Molecular cloning and characterization of Fasciola gigantica thioredoxin-glutathione reductase
Parasitol. Res.
114
2119-2127
2015
Fasciola gigantica
Manually annotated by BRENDA team
Gaba, S.; Jamal, S.; Drug Discovery Consortium, O.; Scaria, V.
Cheminformatics models for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase
Sci. World J.
2014
957107
2014
Schistosoma mansoni
Manually annotated by BRENDA team
Silvestri, I.; Lyu, H.; Fata, F.; Boumis, G.; Miele, A.E.; Ardini, M.; Ippoliti, R.; Bellelli, A.; Jadhav, A.; Lea, W.A.; Simeonov, A.; Cheng, Q.; Arner, E.S.J.; Thatcher, G.R.J.; Petukhov, P.A.; Williams, D.L.; Angelucci, F.
Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as ''Doorstop'' for NADPH Entry
ACS Chem. Biol.
13
2190-2202
2018
Schistosoma mansoni (Q962Y6), Schistosoma mansoni
Manually annotated by BRENDA team
Lyu, H.; Petukhov, P.A.; Banta, P.R.; Jadhav, A.; Lea, W.A.; Cheng, Q.; Arner, E.S.J.; Simeonov, A.; Thatcher, G.R.J.; Angelucci, F.; Williams, D.L.
Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of Schistosomiasis
ACS Infect. Dis.
6
393-405
2020
Schistosoma mansoni
Manually annotated by BRENDA team
Tripathi, T.; Chetri, P.B.
Potent inhibitors of thioredoxin glutathione reductase grail of anti-Schistosome drug within reach?
ACS Infect. Dis.
6
893-895
2020
Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium
Manually annotated by BRENDA team
Fata, F.; Silvestri, I.; Ardini, M.; Ippoliti, R.; Di Leandro, L.; Demitri, N.; Polentarutti, M.; Di Matteo, A.; Lyu, H.; Thatcher, G.R.J.; Petukhov, P.A.; Williams, D.L.; Angelucci, F.
Probing the surface of a parasite drug target thioredoxin glutathione reductase using small molecule fragments
ACS Infect. Dis.
7
1932-1944
2021
Schistosoma mansoni (A0A3Q0KFL1), Schistosoma mansoni
Manually annotated by BRENDA team
Prum, S.; Plumworasawat, S.; Chaiyadet, S.; Saichua, P.; Thanan, R.; Laha, T.; Laohaviroj, M.; Sripa, B.; Suttiprapa, S.
Characterization and in vitro functional analysis of thioredoxin glutathione reductase from the liver fluke Opisthorchis viverrini
Acta Trop.
210
105621
2020
Opisthorchis viverrini (A0A6C0NKS2), Opisthorchis viverrini
Manually annotated by BRENDA team
Salinas, G.; Gao, W.; Wang, Y.; Bonilla, M.; Yu, L.; Novikov, A.; Virginio, V.G.; Ferreira, H.B.; Vieites, M.; Gladyshev, V.N.; Gambino, D.; Dai, S.
The enzymatic and structural basis for inhibition of Echinococcus granulosus thioredoxin glutathione reductase by gold(I)
Antioxid. Redox Signal.
27
1491-1504
2017
Echinococcus granulosus (Q869D7), Echinococcus granulosus
Manually annotated by BRENDA team
Kalita, P.; Shukla, H.; Gadhave, K.; Giri, R.; Tripathi, T.
Role of the glutaredoxin domain and FAD in the stabilization of thioredoxin glutathione reductase
Arch. Biochem. Biophys.
656
38-45
2018
Fasciola gigantica
Manually annotated by BRENDA team
Kalita, P.; Shukla, H.; Das, K.C.; Tripathi, T.
Conserved Arg451 residue is critical for maintaining the stability and activity of thioredoxin glutathione reductase
Arch. Biochem. Biophys.
674
108098
2019
Fasciola gigantica
Manually annotated by BRENDA team
Kalita, P.; Shukla, H.; Shukla, R.; Tripathi, T.
Biochemical and thermodynamic comparison of the selenocysteine containing and non-containing thioredoxin glutathione reductase of Fasciola gigantica
Biochim. Biophys. Acta Gen. Subj.
1862
1306-1316
2018
Fasciola gigantica
Manually annotated by BRENDA team
Rendon, J.L.; Miranda-Leyva, M.; Guevara-Flores, A.; Martinez-Gonzalez, J.J.; Del Arenal, I.P.; Flores-Herrera, O.; Pardo, J.P.
Insight into the mechanistic basis of the hysteretic-like kinetic behavior of thioredoxin-glutathione reductase (TGR)
Enzyme Res.
2018
3215462
2018
Taenia crassiceps
Manually annotated by BRENDA team
Brandstaedter, C.; Fritz-Wolf, K.; Weder, S.; Fischer, M.; Hecker, B.; Rahlfs, S.; Becker, K.
Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms
FEBS J.
285
542-558
2018
Homo sapiens (Q86VQ6), Homo sapiens
Manually annotated by BRENDA team
Guevara-Flores, A.; Martinez-Gonzalez, J.J.; Herrera-Juarez, A.M.; Rendon, J.L.; Gonzalez-Andrade, M.; Torres Duran, P.V.; Enriquez-Habib, R.G.; Del Arenal Mena, I.P.
Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor
PLoS ONE
14
e0220098
2019
Taenia crassiceps
Manually annotated by BRENDA team