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1.8.1.7: glutathione-disulfide reductase

This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.7

Reaction

2 glutathione +

NADP+
=
glutathione disulfide
 +
NADPH
 +
H+

Synonyms

At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.7 glutathione-disulfide reductase

Specific Activity

Specific Activity on EC 1.8.1.7 - glutathione-disulfide reductase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.009
0.0097
-
hemolysate, at 25°C, pH 8.0
0.01
-
hemolysate, at 25°C, pH 8.0
0.013
-
chloroquine-resistant strains 7G8 and FCR3, crude extract
0.022
-
chloroquine-resistant strain Dd2, crude extract
0.023
-
chloroquine-sensitive strain S106, crude extract
0.03
-
brain homogenate
0.033
-
chloroquine-sensitive strain 3D7, crude extract
0.035
-
chloroquine-sensitive strain HB3, crude extract
0.0362
-
purified enzyme, at pH 7.0 and 22°C
0.039
using NADH as electron donor
0.045
using NADPH as electron donor
0.047
-
chloroquine-resistant strain K1, crude extract
0.11
-
crude liver homogenate, in 100 mM potassium phosphate buffer, pH 7.4, 4 mM EDTA, at 37°C
0.118
CDJ91018
pH 7.8, 37°C
0.119
-
crude supernatant of anoxic enzyme
0.331
-
purified enzyme
0.418
-
crude supernatant of aerobic enzyme
0.46
-
enzyme from soluble extract, at 30°C and pH 7.5
1.07
-
in C6 glioma cells, pH and temperature not specified in the publication
1.18
Achromobacter starkeyi
-
-
1.44
-
anoxic enzyme after 109fold purification
1.5
-
enzyme from hemolysate, at pH 8.0 and 25°C
101.8
-
25°C, pH not specified in the publication
124.7
-
pH 7.2, 25°C
125
-
-
139
-
purified in vitro-synthesized enzyme, 30°C, 0.002 mM FAD
140
-
purified enzyme
145
-
purified enzyme from brain
147
-
purified enzyme from liver
168.8
-
pH 7.5, 25°C
18.6
-
using NADPH as substrate, in 50 mM phosphate buffer at pH 7.0
185.5
-
-
193
-
purified enzyme from brain
193.3
-
-
2.9
-
purified enzyme
20.75
-
after 2139fold purification, at 25°C, pH 8.0
221
-
purified enzyme
23
-
2555fold purified enzyme, at 25°C, pH 8.0
249
-
purified enzyme
262
-
purified enzyme
28
-
after 2800fold purification, at 25°C, pH 8.0
314
-
after 209fold purification, at pH 8.0 and 25°C
320
-
purified enzyme
334
-
recombinant additional enzyme in Escherichia coli
34
-
purified enzyme, with NADH
350
-
purified enzyme
361
-
purified enzyme
373.3
-
purified enzyme
4.9
-
purified enzyme, substrate glutathione disulfide
42 - 60
-
purified enzyme
484
purified native enzyme
5.03
-
purified enzyme
5.5
-
aerobic enzyme after 109fold purification
5.63
-
in HepG2 cells, pH and temperature not specified in the publication
50.75
-
purified erythrocyte enzyme
505
-
purified enzyme
51.25
pH 7.6, and temperature not specified in the publication
62.5
-
purified enzyme from erythrocytes
643
-
89.8fold purified enzyme, in 50 mM potassium phosphate buffer pH 7.0, at 25°C
7.16
-
homogenate, in 50 mM potassium phosphate buffer pH 7.0, at 25°C
73.3
-
after 161fold purification, at 30°C and pH 7.5
86.9
-
purified enzyme
96
-
purified enzyme
additional information