1.8.1.7: glutathione-disulfide reductase
This is an abbreviated version!
For detailed information about glutathione-disulfide reductase, go to the full flat file.
Word Map on EC 1.8.1.7
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1.8.1.7
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dismutase
-
catalase
-
sod
-
malondialdehyde
-
ascorbate
-
s-transferase
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gst
-
glutathione-s-transferase
-
erythrocyte
-
glucose-6-phosphate
-
wistar
-
thiobarbituric
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gsh-px
-
tbars
-
necrosis
-
selenium
-
dehydroascorbate
-
anti-oxidant
-
hydroperoxide
-
cadmium
-
albino
-
hepatoprotective
-
hepatotoxicity
-
riboflavin
-
non-enzymatic
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seedling
-
gill
-
chlorophyll
-
dt-diaphorase
-
cumene
-
medicine
-
selenium-dependent
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lipoperoxidation
-
sulfoximine
-
glyoxalase
-
gamma-glutamyl
-
alpha-tocopherol
-
transpeptidase
-
pro-oxidant
-
cuznsod
-
dienes
-
trypanothione
-
glutaredoxins
-
glutathione-dependent
-
guaiacol
-
buthionine
-
1.15.1.1
-
acid-reactive
-
mn-sod
-
pharmacology
-
lipoamide
-
gamma-glutamylcysteine
- 1.8.1.7
- dismutase
- catalase
- sod
- malondialdehyde
- ascorbate
- s-transferase
- gst
- glutathione-s-transferase
- erythrocyte
- glucose-6-phosphate
- wistar
-
thiobarbituric
- gsh-px
-
tbars
- necrosis
- selenium
- dehydroascorbate
-
anti-oxidant
- hydroperoxide
- cadmium
-
albino
-
hepatoprotective
-
hepatotoxicity
- riboflavin
-
non-enzymatic
- seedling
- gill
- chlorophyll
- dt-diaphorase
- cumene
- medicine
-
selenium-dependent
-
lipoperoxidation
- sulfoximine
- glyoxalase
-
gamma-glutamyl
- alpha-tocopherol
- transpeptidase
-
pro-oxidant
-
cuznsod
-
dienes
- trypanothione
- glutaredoxins
-
glutathione-dependent
- guaiacol
-
buthionine
-
1.15.1.1
-
acid-reactive
- mn-sod
- pharmacology
- lipoamide
- gamma-glutamylcysteine
Reaction
2 glutathione
+
Synonyms
At3g54660, EC 1.6.4.2, GLR, glutahione reductase, glutathione disulfide reductase, glutathione reductase, glutathione reductase (NADPH), glutathione reductase 3, glutathione reductase Glr1, glutathione S-reductase, glutathione: NADP(+) oxidoreductase, glutathione: NADP+ oxidoreductase, glutathione:NADP+ oxidoreductase, Gor, GOR1, GOR2, GR, GR1, GR2, Gr3, GRase, GRase-1, GRd, GSH reductase, GSHR, Gsr, GSR-1, GSSG reductase, HCOI_01258400, hGR, HvGR1, HvGR2, multifunctional thioredoxin-glutathione reductase, NADPH-glutathione reductase, NADPH-GSSG reductase, NADPH-reduced GR, NADPH: oxidized glutathione oxidoreductase, NADPH:oxidized glutathione oxidoreductase, NADPH:oxidized-glutathione oxidoreductase, OBP29, PfGR, psgr, PtGR1.1, PtGR1.2, PtGR2, reductase, glutathione, SpGR, TaGR1, TaGR2, TGR, thioredoxin glutathione reductase, thioredoxin/glutathione reductase, TrxR3
ECTree
1.8.1.7 glutathione-disulfide reductaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.8.1.7 - glutathione-disulfide reductase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glutathione disulfide + NADPH
glutathione + NADP+
-
enzyme is required for disposal of peroxides and radicals especially in the brain
-
-
?
glutathione disulfide + NADPH
glutathione + NADP+
-
key enzyme in maintaining the reducing environment in the cell, maintainance of sulfhydryl redox potential in the cytoplasm
-
-
?
glutathione disulfide + NADPH
glutathione + NADP+
-
enzyme is required for disposal of peroxides and radicals especially in the brain
-
-
?
glutathione disulfide + NADPH
glutathione + NADP+
-
enzyme produces glutathione in spermatozoa which is required for reduction and antioxidant defense by glutathione peroxidase, enzyme is involved in protection of the cells against oxidative damage, regulatory of pentose phosphate pathway, pathway overview
-
-
?
glutathione disulfide + NADPH
glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH
glutathione + NADP+
-
antioxidant enzyme, protects the pancreatic cell against reactive oxygen species involved in the diabetogenic agent-induced dysfunction of pancreatic-beta-cells
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
WP_010214957
the enzyme is an important oxidoreductase that helps maintain redox homeostasis
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
glutathione + NADP+
-
-
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
high intracellular concentration of glutathione is important for functionality of thiol groups of cellular proteins
-
-
ir
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2
-
-
?
GSSG + NADPH
glutathione + NADP+
Escherichia coli B / ATCC 11303
-
production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2
-
-
?
GSSG + NADPH
glutathione + NADP+
-
production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2
-
-
?
GSSG + NADPH
glutathione + NADP+
-
production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
role in cell division cycle and in stress adaption on cellular level
-
-
?
GSSG + NADPH
glutathione + NADP+
-
probably major source of NADP+ for the pentose phosphate pathway in the lens
-
-
?
GSSG + NADPH
glutathione + NADP+
-
special role in cells that do no longer produce macromolecules
-
-
r
GSSG + NADPH
glutathione + NADP+
-
maintenance of high levels of GSH in cytoplasm
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
enzyme plays a key role in nutrient-induced increase in the thiol content of pancreatic-islet cells and this increase itself participates in the coupling of metabolic to secretory events
-
-
?
GSSG + NADPH
glutathione + NADP+
-
production of substrate for: glutathione peroxidase EC 1.11.1.9, glutathione-homocystine oxidoreductase EC 1.8.4.1, glutathione-protein disulfide oxidoreductase EC 1.8.4.2
-
-
?, ir
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
GSSG + NADPH
glutathione + NADP+
-
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
-
-
?
S-allylmercaptoglutathione disulfide + NADPH + H+
2 S-allylmercaptoglutathione + NADP+
-
-
-
-
?
S-allylmercaptoglutathione disulfide + NADPH + H+
2 S-allylmercaptoglutathione + NADP+
-
-
-
-
?
additional information
?
-
-
enzyme is connected to neuronal loss during progression of neurodegenerative disorders
-
-
?
additional information
?
-
-
drug resistance to doxorubicin or selenite does not influence the enzyme activity in lung cancer cells
-
-
?
additional information
?
-
-
enzyme is connected to neuronal loss during progression of neurodegenerative disorders like Alzheimer's or Parkinson's disease
-
-
?
additional information
?
-
-
prior inhibition of glutathione reductase activity protects against the toxicity of Cr6+ to a significant extent, suggesting that it reduces Cr6+ to a toxic metabolite
-
-
?
additional information
?
-
-
enzyme forms a disulfide bond formation system together with glutathione peroxidase GPx4, selenium regulates the enzyme expression pattern
-
-
?
additional information
?
-
-
the antioxidant enzyme is important in the parasite sensitive to oxidative stress
-
-
?
additional information
?
-
-
enzyme forms a disulfide bond formation system together with glutathione peroxidase GPx4
-
-
?
additional information
?
-
-
modulation of the redox state of tubulin by an artificial glutathione/glutaredoxin reductase system, repair of peroxynitrite-induced disulfides in porcine brain tubulin, overview
-
-
?
additional information
?
-
-
no activity with L-gamma-glutamyl-2-methyl-L-cysteinyl-glycine disulfide
-
-
?
