1.8.1.5: 2-oxopropyl-CoM reductase (carboxylating)

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For detailed information about 2-oxopropyl-CoM reductase (carboxylating), go to the full flat file.

Reaction

Synonyms

2-ketopropyl coenzyme M oxidoreductase/carboxylase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase, 2-KPCC, More, NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase, NADPH:2-ketopropyl-coenzyme M carboxylase/oxidoreductase, NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase, NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase, xecC

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)

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Results	in table
6	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
13	Cofactor
4	Crystallization (Commentary)
2	General Information
4	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
16	PDB ID
1	pH Optimum
9	Protein Variants
2	Purification (Commentary)
3	Reaction
3	Reaction Type
13	Reference
2	Specific Activity [micromol/min/mg]
28	Substrates and Products (Substrate)
5	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Reference

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Reference on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

288637

Allen, J.R.; Clark, D.D.; Krum, J.G.; Ensign, S.A.

A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation

Proc. Natl. Acad. Sci. USA

96

8432-8437

1999

Xanthobacter sp., Xanthobacter sp. Py2

10411892

brenda

288638

Clark, D.D.; Allen, J.R.; Ensign, S.A.

Characterization of five catalytic activities associated with the NADPH:2-ketopropyl-coenzyme M [2-(2-ketopropylthio)ethanesulfonate] oxidoreductase/carboxylase of the Xanthobacter strain Py2 epoxide carboxylase system

Biochemistry

39

1294-1304

2000

Xanthobacter sp., Xanthobacter sp. Py2

10684609

brenda

288639

Jang, S.B.; Jeong, M.S.; Clark, D.D.; Ensign, S.A.; Peters, J.W.

Crystallization and preliminary X-ray analysis of a NADPH 2-ketopropyl-coenzyme M oxidoreductase/carboxylase

Acta Crystallogr. Sect. D

57

445-447

2001

Xanthobacter sp.

11223527

brenda

657919

Nocek, B.; Jang, S.B.; Jeong, M.S.; Clark, D.D.; Ensign, S.A.; Peters, J.W.

Structural basis for CO2 fixation by a novel member of the disulfide oxidoreductase family of enzymes, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase

Biochemistry

41

12907-12913

2002

Xanthobacter autotrophicus (Q56839)

12390015

brenda

672063

Pandey, A.S.; Nocek, B.; Clark, D.D.; Ensign, S.A.; Peters, J.W.

Mechanistic implications of the structure of the mixed-disulfide intermediate of the disulfide oxidoreductase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase

Biochemistry

45

113-120

2006

Xanthobacter autotrophicus (Q56839)

16388586

brenda

712458

Boyd, J.M.; Clark, D.D.; Kofoed, M.A.; Ensign, S.A.

Mechanism of inhibition of aliphatic epoxide carboxylation by the coenzyme M analog 2-bromoethanesulfonate

J. Biol. Chem.

285

25232-25242

2010

Xanthobacter autotrophicus

20551308

brenda

725008

Pandey, A.S.; Mulder, D.W.; Ensign, S.A.; Peters, J.W.

Structural basis for carbon dioxide binding by 2-ketopropyl coenzyme M oxidoreductase/carboxylase

FEBS Lett.

585

459-464

2011

Xanthobacter autotrophicus (Q56839)

21192936

brenda

725265

Kofoed, M.A.; Wampler, D.A.; Pandey, A.S.; Peters, J.W.; Ensign, S.A.

Roles of the redox-active disulfide and histidine residues forming a catalytic dyad in reactions catalyzed by 2-ketopropyl coenzyme M oxidoreductase/carboxylase

J. Bacteriol.

193

4904-4913

2011

Xanthobacter autotrophicus (Q56839)

21764916

brenda

742523

Prussia, G.A.; Gauss, G.H.; Mus, F.; Conner, L.; DuBois, J.L.; Peters, J.W.

Substitution of a conserved catalytic dyad into 2-KPCC causes loss of carboxylation activity

FEBS Lett.

590

2991-2996

2016

Xanthobacter autotrophicus (Q56839)

27447465

brenda

765060

Streit, B.R.; Mattice, J.R.; Prussia, G.A.; Peters, J.W.; DuBois, J.L.

The reactive form of a C-S bond-cleaving, CO2-fixing flavoenzyme

J. Biol. Chem.

294

5137-5145

2019

Xanthobacter autotrophicus (Q56839)

30696768

brenda

765078

Prussia, G.A.; Shisler, K.A.; Zadvornyy, O.A.; Streit, B.R.; DuBois, J.L.; Peters, J.W.

The unique Phe-His dyad of 2-ketopropyl coenzyme M oxidoreductase/carboxylase selectively promotes carboxylation and S-C bond cleavage

J. Biol. Chem.

297

100961

2021

Xanthobacter autotrophicus (Q56839)

34265301

brenda

Entries 1 - 20 of 11

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