1.8.1.5: 2-oxopropyl-CoM reductase (carboxylating)
This is an abbreviated version!
For detailed information about 2-oxopropyl-CoM reductase (carboxylating), go to the full flat file.
Word Map on EC 1.8.1.5
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1.8.1.5
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propylene
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thioether
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co2
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acetone
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xanthobacter
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flavin
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2-bromoethanesulfonate
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dyad
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co2-fixing
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fad-containing
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epoxypropane
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epoxide
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autotrophicus
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phe-his
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pka
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electrophile
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thioredoxins
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his-glu
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interchange
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encapsulate
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air-oxidized
- 1.8.1.5
- propylene
- thioether
- co2
- acetone
- xanthobacter
- flavin
- 2-bromoethanesulfonate
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dyad
-
co2-fixing
-
fad-containing
- epoxypropane
- epoxide
- autotrophicus
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phe-his
- pka
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electrophile
- thioredoxins
- his-glu
-
interchange
-
encapsulate
-
air-oxidized
Reaction
Synonyms
2-ketopropyl coenzyme M oxidoreductase/carboxylase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase, 2-KPCC, More, NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase, NADPH:2-ketopropyl-coenzyme M carboxylase/oxidoreductase, NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase, NADPH:2-ketopropyl-CoM oxidoreductase/carboxylase, xecC
ECTree
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Reaction
Reaction on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)
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2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
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2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
detailed reaction mechanism in a catalytic cycle, active site structure
2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
reaction mechanism for 2-KPCC begins with formation of enzyme-substrate disulfide adduct by the reduced form of the redox active disulfide. This step is followed by release of enolacetone anion intermediates for 2-KPCC. The primary catalytic fate of the enolacetone intermediate for the wild-type (Phe501) or variant (His501) 2-KPCC is acetoacetate or acetone, respectively