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1.8.1.12: trypanothione-disulfide reductase

This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.12

Reaction

trypanothione
+
NADP+
=
trypanothione disulfide
 +
NADPH
 +
H+

Synonyms

EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.12 trypanothione-disulfide reductase

KI Value

KI Value on EC 1.8.1.12 - trypanothione-disulfide reductase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.079
(+/-)-10,11-dihydrolunarine
Lunaria biennis
-
-
0.00005
(1,3,5-triaza-7-phosphaadamantane)Au(saccharine)
-
at pH 7.5 and 25°C
-
0.03
(6-benzyloxycarbonylamino-6-[[[methyl-(2-propylamino-ethyl)-carbamoyl]-methyl]-carbamoyl]-1-[[(3-propylamino-propylcarbamoyl)-methyl]-carbamoyl]-hex-3-enyl)-carbamic acid benzyl ester
-
-
0.048
(6-benzyloxycarbonylamino-6-[[[methyl-(2-propylamino-ethyl)-carbamoyl]-methyl]-carbamoyl]-1-[[(3-propylamino-propylcarbamoyl)-methyl]-carbamoyl]-hexyl)-carbamic acid benzyl ester
-
-
0.002
1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide]
-
-
0.0019
1,1'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis(3-benzyl-1,3-dihydro-2H-benzimidazol-2-imine)
-
-
0.0269
1,3-bis[3-(dimethylamino)propyl]-1,5-dihydro-2H-pyrimido[4,5-beta][1,4]benzothiazine-2,4(3H)-dione
-
-
0.0011
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
at 25°C, pH not specified in the publication
0.001
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)piperidine
-
-
0.002
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
at 25°C, pH not specified in the publication
0.005
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
at 25°C, pH not specified in the publication
0.0036
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
-
-
0.0054
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
-
-
0.216
1-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine
-
0.023
10-[3-(4-methylpiperidin-1-yl)propyl]-2-(trifluoromethyl)-10,10a-dihydro-4aH-phenothiazine
-
0.0212
2-(1-[3-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]propyl]piperidin-4-yl)ethanol
-
0.011
2-(4-[4-amino-6,7-bis[2-(dimethylamino)ethoxy]quinazolin-2-yl]piperazin-1-yl)naphthalene-1,4-dione
-
-
0.15
2-amino-4-chlorophenyl phenyl sulfide
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.0187
2-chloro-10-[3-[(Z)-propyldiazenyl]propyl]-10,10a-dihydro-4aH-phenothiazine
-
0.032
2-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-5-methoxycyclohexa-2,5-diene-1,4-dione
-
-
0.0075
2-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]naphthalene-1,4-dione
-
-
0.0017
3',4'-dichlorobenzyl-[5-chloro-2-(phenylsulfanylphenylamino)-propyl]-dimethylammonium chloride
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.00044
3,4-dichloro-N-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-N,N-dimethylanilinium
-
0.0008 mM, at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.00169
3,4-dichloro-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.0108
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium
-
0.127
3-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
-
0.007
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
0.008
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
0.084 - 0.158
3-([2-[(4-tert-butylphenyl)amino]-5-fluorophenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
0.007
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
0.01
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
0.0017 - 0.0084
3-acetylpyridine adenine nucleotide
0.0065
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.02
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
0.006
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
0.009
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
-
-
0.009
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-aminium chloride
-
-
0.128
4,15-iso-atriplicolide tiglate
-
pH 7.5, 25°C
-
0.002
4,4'-bis(4-benzyloxy-3-methoxybenzimidoylamino)di-cyclohexylmethane
-
-
0.0046
4-((1-(4-ethylphenyl)-2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-3-yl)methyl)thiomorpholine
at 20°C, pH not specified in the publication
0.0066
4-(benzyloxy)-N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.027
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-(phenylsulfanyl)aniline
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.118
5-nitro-furan-2-carboxylic acid (3-dimethylamino-propyl)-amide
pH 7.5, 30°C
0.061
5-nitrofuran-2-carboxylic acid benzylamide
pH 7.5, 30°C
0.068
5-nitrofuran-2-carboxylic acid dibenzylamide
pH 7.5, 30°C
0.00025
6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine
pH not specified in the publication, temperature not specified in the publication
0.08
6-chlorotacrine
-
-
0.14
9-Amino-1,2,3,4-tetrahydroacridine
-
-
0.007 - 0.043
9-aminoacridine derivatives
-
-
0.021 - 0.037
9-thioacridine derivatives
-
-
0.011 - 0.607
acylspermines and acylspermidines
-
-
0.0936
amitryptyline
0.0646
aspidospermine
-
-
0.00009
Au(2-(2'-pyridyl)benzimidazole)Cl2
-
at pH 7.5 and 25°C
-
0.025
Au-(N-(1-hydroxy-3-methylbutan-2-yl)pyridine-2-carboxamide)Cl
-
at pH 7.5 and 25°C
-
0.00016
AuCl3
-
at pH 7.5 and 25°C
0.000155
auranofin
-
at pH 7.5 and 25°C
0.016
bis(9H-fluoren-9-ylmethyl) [(18S,23S)-3,14,17,24-tetraoxo-1,4,8,13,16-pentaazacyclotetracosane-18,23-diyl]biscarbamate
-
-
0.0076
cepharanthine
-
-
0.0045
chinifur
-
-
0.0108
chlorpromazine
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.101
cis-3-(1,3-dioxolan-2-yl)-8-bromo-9b-(trans-acrylic acid)-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
-
0.059
cis-3-oxo-8,9b-bis-(trans-N1-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
-
0.093
cis-3-oxo-8,9b-bis-(trans-N3-(dimethylamino)propylacrylamido)-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
-
0.049
cis-3-oxo-8-trans-(N1-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
-
0.0065 - 0.0086
clomipramine
0.194
cycleanine
-
-
0.826
dethiotrypanothione
-
-
0.145
dibenzyl [(18S,23S)-3,14,17,24-tetraoxo-1,4,8,13,16-pentaazacyclotetracosane-18,23-diyl]biscarbamate
-
-
0.0018
kukoamine A
-
-
0.00014
K[Au(saccharine)2]
-
at pH 7.5 and 25°C
0.0002
K[Au(saccharine)4]
-
at pH 7.5 and 25°C
0.144 - 0.304
lunarine
0.47
lunarinol
Lunaria biennis
-
-
0.016 - 0.0172
Melarsen oxide
0.009 - 0.036
melarsen-trypanothione disulfide-adduct
0.012
MelT
-
pH 7.5, 27°C
0.019
Mepacrine
0.066
N'-[5-chloro-2-(phenylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.0591
N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-aminium
-
0.0302
N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-aminium
-
0.035
N,N-dimethyl-N-[3-(7-methoxy-1-methyl-3,4-dihydro-9H-beta-carbolin-9-yl)propyl]amine
-
-
0.028 - 0.72
N-(3,4-dichlorobenzyl)-3-[(5-fluoro-2-[[4-(pentafluoro-l6-sulfanyl)phenyl]amino]phenyl)amino]-N,N-dimethylpropan-1-aminium chloride
0.0246
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-phenylacetamide
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.0428
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-4-nitrobenzamide
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.0245
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]benzamide
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.0113
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]butanamide
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.02
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]propanamide
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.009
N-[2-[(naphthalen-1-ylacetyl)amino]ethyl]-4-[[(3-nitrophenyl)(oxo)acetyl]amino]piperidine-4-carboxamide
-
mixed type inhibitor, 0.1 mM
0.0053
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-4-(diphenylmethoxy)-N,N-dimethylanilinium
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.0142
N-[3-([2-[(4-chlorophenyl)sulfanyl]phenyl]amino)propyl]-N,N-dimethylanilinium
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.003
N1,N9-bis-(L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide))-norspermidine
-
-
0.019
N1,N9-bis-(L-tryptophanyl)-norspermidine
-
-
0.00016
N1,N9-bis-(L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide))-norspermidine
-
-
0.014
N1,N9-bis-(L-tryptophanyl-L-arginyl)-norspermidine
-
-
0.069
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-acetyl-norspermidine
-
-
0.007
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-hexanoyl-norspermidine
-
-
0.011
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-L-arginyl-norspermidine
-
-
0.131
N1-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-norspermidine
-
-
0.1
N1-L-arginyl-N9-acetyl-norspermidine
-
-
0.1
N1-L-arginyl-N9-hexanoyl-norspermidine
-
-
0.1
N1-L-arginyl-norspermidine
-
-
0.012
N1-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-acetyl-norspermidine
-
-
0.006
N1-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-N9-hexanoyl-norspermidine
-
-
0.009
N1-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-norspermidine
-
-
0.069
N1-L-tryptophanyl-L-arginyl-N9-acetyl-norspermidine
-
-
0.024
N1-L-tryptophanyl-L-arginyl-N9-hexanoyl-norspermidine
-
-
0.00022
N1-L-tryptophanyl-L-arginyl-N9-L-tryptophanyl-L-arginyl(2,2,5,7,8-pentamethylchroman-6-sulfonamide)-norspermidine
-
-
0.083
N1-L-tryptophanyl-L-arginyl-norspermidine
-
-
0.1
N1-L-tryptophanyl-N9-acetyl-norspermidine
-
-
0.1
N1-L-tryptophanyl-N9-hexanoyl-norspermidine
-
-
0.1
N1-L-tryptophanyl-norspermidine
-
-
0.0075
N1N8-bis(dihydrocaffeoyl)spermidine
-
-
0.011 - 0.014
NADP+
0.04 - 0.245
nifurtimox
0.16
numismine
Lunaria biennis
-
-
0.01
phenothiazines
-
-
-
0.096
tetrahydrolunarine
Lunaria biennis
-
-
0.218
tetrahydrolunarinol
Lunaria biennis
-
-
0.0054 - 0.051
thio-NADP+
0.0219
trifluoroperazine
pH and temperature not specified in the publication
0.023
Trifluperazine
-
at pH 7.25, 25°C in 0.02 M HEPES buffer containing 0.15 M KCl, 1 mM EDTA, 0.1 mM NADPH
0.00004
[(2,2'-bipyridine)Au(OH)2][PF6]
-
at pH 7.5 and 25°C
-
0.074
[6-benzyloxycarbonylamino-1,6-bis-(dimethylcarbamoylmethyl-carbamoyl)-hex-3-enyl]-carbamic acid benzyl ester
-
-
0.091
[6-benzyloxycarbonylamino-1,6-bis-(dimethylcarbamoylmethyl-carbamoyl)-hexyl]-carbamic acid benzyl ester
-
-
0.000185
[Au((S)-4-Bn-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
-
at pH 7.5 and 25°C
-
0.000075
[Au((S)-4-iPr-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
-
at pH 7.5 and 25°C
-
0.000068
[Au2(bipy)2(m-O)2](PF6)2
-
at pH 7.5 and 25°C
-
0.000022
[Cl2AuIII(2-(2'-pyridyl)benzimidazole)AuI(PPh3)](PF6)
-
at pH 7.5 and 25°C
-
additional information
additional information
-