1.7.3.1: nitroalkane oxidase
This is an abbreviated version!
For detailed information about nitroalkane oxidase, go to the full flat file.
Word Map on EC 1.7.3.1
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1.7.3.1
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atlantic
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oscillation
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climate
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winter
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atmospheric
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orange
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robot
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weather
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acridine
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ocean
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interannual
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summer
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arctic
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nai
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phenology
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cardiolipin
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humanoid
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forecast
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warmer
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nonyl
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rainfall
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meteorological
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hydrological
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seabird
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snow
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latitudinal
- 1.7.3.1
-
atlantic
-
oscillation
-
climate
-
winter
-
atmospheric
- orange
-
robot
-
weather
- acridine
-
ocean
-
interannual
-
summer
-
arctic
- nai
-
phenology
- cardiolipin
-
humanoid
-
forecast
-
warmer
-
nonyl
-
rainfall
-
meteorological
-
hydrological
-
seabird
-
snow
-
latitudinal
Reaction
Synonyms
2-npdl, More, NAO, NaoA, nitroalkane oxidase, nitroalkane-oxidizing enzyme, nitroethane oxidase, nitroethane:oxygen oxidoreductase, NOE, oxidase, nitroethane, PA4202
ECTree
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Reaction
Reaction on EC 1.7.3.1 - nitroalkane oxidase
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
mechanism
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
ping pong kinetic mechanism
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
Asp402 acts as the active site base of the enzyme, mechanism, substrate CH-bond cleavage is rate limiting for the reduction of the enzyme by nitroethane
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
Asp402 acts as the active site base of the enzyme, mechanism: catalysis is initiated by the active site base Asp402 that deprotonates the neutral substrate to yield a carbanion that can attack the N-5 position of the oxidized flavin, CH-bond cleavage is rate limiting for the reduction of the enzyme by nitroethane
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
detailed mechanism, with carbanion reaction intermediate formation, an aspartate residue is the active site base, substrate CH-bond cleavage is rate limiting for the reduction of the enzyme by nitroethane, the active site of the enzyme is a hydrophobic channel, tunneling, overview
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
mechanism, involves removal of a proton from the nitroalkane, forming a carbanion which adds to the N5 of the flavin, elimination of nitrite from the resulting adduct forms an electrophilic imine intermediate which can be attacked by hydroxide
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
mechanism, transition-state stabilization is essential, protein-substrate interactions in the transition state, reaction involves quantum mechaniscal tunneling, Asp402 is involved in initial abstraction of a proton from the neutral substrate, overview
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ethylnitronate + O2 + FMNH2 = acetaldehyde + nitrite + FMN + H2O
critical importance of the interaction between Asp402 and Arg409 for proton abstraction by nitroalkane oxidase
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