1.7.1.B2: aromatic nitroreductase [NAD(P)H]

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For detailed information about aromatic nitroreductase [NAD(P)H], go to the full flat file.

Reaction

Synonyms

NfnB, NfsB, NfsB_Ec, NfsB_Pa, NprA, oxygen-insensitive nitroreductase (NAD(P)H), YfkO

ECTree

     1 Oxidoreductases

         1.7 Acting on other nitrogenous compounds as donors

             1.7.1 With NAD⁺ or NADP⁺ as acceptor

                1.7.1.B2 aromatic nitroreductase [NAD(P)H]

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Results	in table
4	AA Sequence
1	Application
7	Cloned(Commentary)
9	Cofactor
4	General Information
27	IC50 Value
8	Inhibitors
30	kcat/KM [mM/s]
32	KM Value [mM]
1	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
11	Organism
1	pH Optimum
20	Protein Variants
5	Purification (Commentary)
5	Reaction
11	Reference
33	Substrates and Products (Substrate)
1	Subunits
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
31	Turnover Number [1/s]

Reaction

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Reaction on EC 1.7.1.B2 - aromatic nitroreductase [NAD(P)H]

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

an aromatic amine + 3 NAD(P)+ + 2 H2O = an aromatic nitrate + 3 NAD(P)H + 3 H+

2 entries

an aromatic amine + NAD(P)+ + H2O = an aromatic hydroxylamine + NAD(P)H + H+

(1a)

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an aromatic hydroxylamine + NAD(P)+ = an aromatic nitric oxide + NAD(P)H + H+

(1b)

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an aromatic nitric oxide + NAD(P)+ + H2O = an aromatic nitrate + NAD(P)H + H+

(1c)

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an aromatic amine + 3 NAD(P)+ + 2 H2O = an aromatic nitrate + 3 NAD(P)H + 3 H+

(overall reaction)

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an aromatic amine + 3 NAD(P)+ + 2 H2O = an aromatic nitrate + 3 NAD(P)H + 3 H+

in vivo the reaction is obseverved in the opposite direction from that shown in the equation

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