1.7.1.7: GMP reductase
This is an abbreviated version!
For detailed information about GMP reductase, go to the full flat file.
Word Map on EC 1.7.1.7
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1.7.1.7
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purine
-
imp
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salvage
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hypoxanthine
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impdhs
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hypoxanthine-guanine
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adenylosuccinate
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medicine
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drug development
- 1.7.1.7
- purine
- imp
-
salvage
- hypoxanthine
- impdhs
-
hypoxanthine-guanine
- adenylosuccinate
- medicine
- drug development
Reaction
Synonyms
EC 1.6.6.8, GMPR, GMPR-I, GMPR-II, GMPR2, guaC, Guanosine 5'-monophosphate oxidoreductase, guanosine 5'-monophosphate reductase, guanosine monophosphate reductase, guanosine monophosphate reductase 2, guanosine-5'-monophosphate reductase, guanylate reductase, HsGMPR1, HsGMPR2, LmGMPR, Lmj17.0725, LMJF_17_0725, NADPH:GMP oxidoreductase (deaminating), reductase, guanylate, Tb927.5.2080, TbGMPR, TcGMPR, TCIL3000_5_1940
ECTree
1.7.1.7 GMP reductaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.7.1.7 - GMP reductase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
6-Chloro-9-beta-D-ribofuranosylpurine 5'-phosphate
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0.01 mM, 80% inhibition after 40 min, 1 mM GMP protect
p-mercuribenzoate
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2 mM, complete inhibition, complete protection by 2 mM GSH
ATP
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no inhibition without Mg2+, MgATP: no inhibition at 0.010 mM-0.100 mM GMP, strong inhibition below 0.010 mM
mizoribine 5'-monophosphate
MZP, moderate inhibition; MZP, moderate inhibition
XMP
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0.001 mM, more than 50% inhibition; GTP and diguanosine tetraphosphate counteract inhibition
additional information
no inhibition by ribavirin 5'-monophosphate; no inhibition by ribavirin 5'-monophosphate
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additional information
no inhibition by ribavirin 5'-monophosphate; no inhibition by ribavirin 5'-monophosphate
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additional information
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not inhibited by KCN
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additional information
ribavirin acts as an anti-trypanosomal drug in vitro with IC50 = 0.0254 mM
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