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1.7.1.7: GMP reductase

This is an abbreviated version!
For detailed information about GMP reductase, go to the full flat file.

Word Map on EC 1.7.1.7

Reaction

IMP
+
NH3
+
NADP+
=
GMP
+
NADPH
+
H+

Synonyms

EC 1.6.6.8, GMPR, GMPR-I, GMPR-II, GMPR2, guaC, Guanosine 5'-monophosphate oxidoreductase, guanosine 5'-monophosphate reductase, guanosine monophosphate reductase, guanosine monophosphate reductase 2, guanosine-5'-monophosphate reductase, guanylate reductase, HsGMPR1, HsGMPR2, LmGMPR, Lmj17.0725, LMJF_17_0725, NADPH:GMP oxidoreductase (deaminating), reductase, guanylate, Tb927.5.2080, TbGMPR, TcGMPR, TCIL3000_5_1940

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.7 GMP reductase

Disease

Disease on EC 1.7.1.7 - GMP reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer's disease.
Breast Neoplasms
Lack of expression of the proteins GMPR2 and PPAR? are associated with the basal phenotype and patient outcome in breast cancer.
Carcinogenesis
Lack of expression of the proteins GMPR2 and PPAR? are associated with the basal phenotype and patient outcome in breast cancer.
Carcinoma, Hepatocellular
Methotrexate decreases thymidine kinase activity.
Gout
Erythrocyte adenosine kinase activity in gout.
Leukemia
Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells.
Reciprocal alterations of GMP reductase and IMP dehydrogenase activities during differentiation in HL-60 leukemia cells.
Leukemia, Myeloid, Acute
An integrated map of human chromosome 6p23.
Melanoma
A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.
Neoplasms
Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways.
Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells.
Diverse proteomic alterations in gastric adenocarcinoma.
Spinocerebellar Ataxias
An integrated map of human chromosome 6p23.
Starvation
Inhibition of cellular growth by increased guanine nucleotide pools. Characterization of an Escherichia coli mutant with a guanosine kinase that is insensitive to feedback inhibition by GTP.