1.7.1.7: GMP reductase

This is an abbreviated version!
For detailed information about GMP reductase, go to the full flat file.

Word Map on EC 1.7.1.7

1.7.1.7

purine

imp

salvage

hypoxanthine

impdhs

hypoxanthine-guanine

adenylosuccinate

medicine

drug development

Reaction

Synonyms

EC 1.6.6.8, GMPR, GMPR-I, GMPR-II, GMPR2, guaC, Guanosine 5'-monophosphate oxidoreductase, guanosine 5'-monophosphate reductase, guanosine monophosphate reductase, guanosine monophosphate reductase 2, guanosine-5'-monophosphate reductase, guanylate reductase, HsGMPR1, HsGMPR2, LmGMPR, Lmj17.0725, LMJF_17_0725, NADPH:GMP oxidoreductase (deaminating), reductase, guanylate, Tb927.5.2080, TbGMPR, TcGMPR, TCIL3000_5_1940

ECTree

1 Oxidoreductases

1.7 Acting on other nitrogenous compounds as donors

1.7.1 With NAD⁺ or NADP⁺ as acceptor

1.7.1.7 GMP reductase

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Results	in table
10	Activating Compound
9196	AA Sequence
3	Application
1	CAS Registry Number
13	Cloned(Commentary)
27	Cofactor
3	Crystallization (Commentary)
45	Disease/ Diagnostics
1	Expression
13	General Information
1	General Stability
4	IC50 Value
75	Inhibitors
2	kcat/KM [mM/s]
10	Ki Value [mM]
40	KM Value [mM]
5	Localization
9	Metals/Ions
16	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
46	Organism
4	Pathway
32	PDB ID
12	pH Optimum
4	pH Range
1	pI Value
1	Posttranslational Modification
5	Protein Variants
14	Purification (Commentary)
6	Reaction
4	Reaction Type
40	Reference
44	Source Tissue
16	Specific Activity [micromol/min/mg]
5	Storage Stability
48	Substrates and Products (Substrate)
10	Subunits
53	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

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Cloned on EC 1.7.1.7 - GMP reductase

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cDNA

expressed in Escherichia coli

Homo sapiens

675363

expressed in Escherichia coli BL21(DE3) cells

Trypanosoma brucei

765448

expressed in Escherichia coli M15 as His-tag fusion protein

Homo sapiens

657445

expression in Escherichia coli

2 entries

gene LMJF_17_0725, DNA and amino acid sequence determination and analysis, , the gene has a 131 amino acid insertion encoding two tandem CBS domains, sequence comparisons, recombinant expression in Escherichia coli strain H1174

Leishmania major

Q4QEB3

743300

gene Tb927.5.2080, recombinant expression of GST-tagged enzyme in Escherichia coli strain BL21 (DE3)

Trypanosoma brucei brucei

Q57ZS7

743568

gene TCIL3000_5_1940, recombinant expression in Escherichia coli

Trypanosoma congolense

G0UMT0

743397

in vitro transcription/translation

Escherichia coli

394279

overexpression of wild-type and mutant enzymes in SK-Mel-103 melanoma cells

Homo sapiens

P36959

742245

transfection of HL-60 leukemia cells, expressed in COS-7 cells as His-tag fusion protein

Homo sapiens

Q9P2T1

659550