1.6.99.1: NADPH dehydrogenase

This is an abbreviated version!
For detailed information about NADPH dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-cyclohexen-1-one, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate, diaphorase, dihydronicotinamide adenine dinucleotide phosphate dehydrogenase, EBP, Estrogen-binding protein, NADP-d, NADPH diaphorase, NADPH-d, NADPH-dehydrogenase, NADPH-dependent cyclohexenone reductase, NADPH-dependent diaphorase, NADPH-diaphorase, NADPH-methemoglobin reductase, NADPH2-dehydrogenase, NCR, nicotinamide adenine dinucleotide phosphate diaphorase, nitric oxide synthase, old yellow enzyme, Old yellow enzyme homolog, OYE, OYE1, OYE2, OYE3, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, SYE4, TPNH dehydrogenase, TPNH-diaphorase, triphosphopyridine diaphorase, triphosphopyridine nucleotide diaphorase, YqjM

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.99 With unknown physiological acceptors

                1.6.99.1 NADPH dehydrogenase

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Results	in table
3083	AA Sequence
3	Application
1	CAS Registry Number
7	Cloned(Commentary)
34	Cofactor
4	Crystallization (Commentary)
13818	Disease/ Diagnostics
1	Expression
4	General Information
10	Inhibitors
1	Ki Value [mM]
23	KM Value [mM]
4	Localization
2	Metals/Ions
17	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
316	Organism
87	PDB ID
2	pH Optimum
2	Protein Variants
6	Purification (Commentary)
3	Reaction
3	Reaction Type
45	Reference
36	Source Tissue
66	Substrates and Products (Substrate)
11	Subunits
53	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
23	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.6.99.1 - NADPH dehydrogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2-cyclohexen-1-one + NADPH + H+

cyclohexanone + NADP+

2 entries

NADPH + acceptor

NADP+ + reduced acceptor

3 entries

NADPH + H+ + 2-cyclohexen-1-one

NADP+ + ?

Shewanella oneidensis

-

the substrate results in a very rapid and strong reduction of SYE4

671848

-

-

?

NADPH + H+ + acceptor

NADP+ + reduced acceptor

2 entries

NADPH + H+ + acrolein

NADP+ + propionaldehyde

3 entries

NADPH + H+ + NEM

NADP+ + ?

Shewanella oneidensis

-

the substrate results in a very rapid and strong reduction of SYE4

671848

-

-

?

NADPH + H+ + nitroglycerin

NADP+ + ?

Shewanella oneidensis

-

the substrate results in a very rapid and strong reduction of SYE4

671848

-

-

?

NADPH + H+ + prostaglandin H2

NADP+ + prostaglandin F2alpha

Trypanosoma cruzi

-

via FMN cofactor, stereoselective reaction mechanism

725313

-

-

?

additional information

?

-

4 entries

2-cyclohexen-1-one + NADPH + H+

cyclohexanone + NADP+

Bacillus subtilis

-

-

740575

-

-

?

2-cyclohexen-1-one + NADPH + H+

cyclohexanone + NADP+

Bacillus subtilis 168

-

-

740575

-

-

?

NADPH + acceptor

NADP+ + reduced acceptor

Manduca sexta

-

the enzyme is transiently activated by pheromone

392795

-

-

?

NADPH + acceptor

NADP+ + reduced acceptor

Rattus norvegicus

-

intracerebral hemorrhage in the internal capsule may induce NADPH-diaphorase activity

392796

-

-

?

NADPH + acceptor

NADP+ + reduced acceptor

Saccharomyces pastorianus

-

physiological role as electron transfer component

392785

-

-

?

NADPH + H+ + acceptor

NADP+ + reduced acceptor

Saccharomyces cerevisiae

-

the one-electron transfer from OYE proceeds more smoothly than the two-electron transfer from OYE. The physiological electron acceptors may be cytochrome b5 or a b5-like protein

671730

-

-

?

NADPH + H+ + acceptor

NADP+ + reduced acceptor

Trypanosoma cruzi

-

-

725313

-

-

?

NADPH + H+ + acrolein

NADP+ + propionaldehyde

Saccharomyces cerevisiae

-

OYE2 protects against acrolin toxicity, the product propionaldehyde is not toxic. OYE2 is required for basal level of tolerance

671466

-

-

?

NADPH + H+ + acrolein

NADP+ + propionaldehyde

Saccharomyces cerevisiae

-

OYE3 protects against acrolin toxicity, the product propionaldehyde is not toxic. OYE3 expression is particularly induced following acrolein stress

671466

-

-

?

NADPH + H+ + acrolein

NADP+ + propionaldehyde

Shewanella oneidensis

-

the substrate results in a very rapid and strong reduction of SYE4

671848

-

-

?

additional information

?

-

Bacillus subtilis

-

involved in detoxification and oxidative stress response

656130

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

OYE3 interferes with Bax- and H2O2-induced lipid peroxidation and cell death in Saccharomyces cerevisiae

673754

-

-

?

additional information

?

-

Trypanosoma cruzi

Q2TJB8

analysis of binding mode of beta-lapachone, a trypanocidal agent, and other naphthoquinones by molecular docking and dynamics: their binding to TcOYE is stabilized mainly by interactions with the isoalloxazine ring from FMN and residues from the active-site pocket

721342

-

-

?

additional information

?

-

Trypanosoma cruzi

-

old yellow enzyme is an NADPH oxidoreductase capable of reducing a variety of compounds, it catalyzes one- or two-electron reduction

725313

-

-

?