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1.6.5.10: NADPH dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about NADPH dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.6.5.10

Reaction

NADPH
+
H+
 +
a quinone
=
NADP+
 +
a quinol

Synonyms

AKR1C9, ArsH, azoreductase, CBR4, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate (quinone), EC 1.6.99.6, MdaB, More, NADPH oxidase, NADPH quinone oxidoreductase, NADPH quinone oxidoreductase 1, NADPH quinone reductase, NADPH-dependent quinone reductase, NADPH-quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NQO1, PA1225, PpAzoR, XAC2229, Zta1p

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                1.6.5.10 NADPH dehydrogenase (quinone)

Engineering

Engineering on EC 1.6.5.10 - NADPH dehydrogenase (quinone)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P187S
-
Pro187Ser polymorphism in NQO1 has a limited role in the development of Tardive dyskinesia (a potentially irreversible side effect of antipsychotic medication treatment that occurs in approximately 25% of chronically treated schizophrenia patients)
Q192R
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 60 min) relative to parental mutant variant B1G6
Q192R/A46P/V159A
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 90 min) relative to parental mutant variant 16B7
Q192R/A46P/V159A/A48P
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 60°C, 45 min) relative to parental mutant variant 2A1
Q192R/A46P/V159A/C129S
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 60°C, 45 min) relative to parental mutant variant 23C10
Q192R/A46P/V159A/C129S/A178D/A31S/K74E/A88G/L143Q
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 85°C, 150 min) relative to parental mutant variant 2F11
Q192R/A46P/V159A/C129S/A178D/A77T/F98L/N131D
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 85°C, 150 min) relative to parental mutant variant 3B9
Q192R/A46P/V159A/C129S/A178D/A88G/N131D/L143Q
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 85°C, 150 min) relative to parental mutant variant 1B6
Q192R/A46P/V159A/C129S/A178D/K74E/L143Q
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 85°C, 150 min) relative to parental mutant variant 2E4
Q192R/A46P/V159A/C129S/A178D/N131D/L143Q
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 85°C, 150 min) relative to parental mutant variant 6F11
Q192R/A46P/V159A/C129S/A77T/N131D
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 14D4
Q192R/A46P/V159A/C129S/D7H/A178D
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 13G10
Q192R/A46P/V159A/C129S/E36D/L143Q
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 1C11
Q192R/A46P/V159A/C129S/I6V/T79R/Y179H
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 32F5
Q192R/A46P/V159A/C129S/K74E/A88G
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 23C5
Q192R/A46P/V159A/C129S/L161M/L169P
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 27E4
Q192R/A46P/V159A/C129S/N14D/L143Q
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 6F10
Q192R/A46P/V159A/C129S/Y179H
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 80°C, 60 min) relative to parental mutant variant 23E4
Q192R/A46P/V159A/Y179H
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 60°C, 45 min) relative to parental mutant variant 19E4
Q192R/Y179H
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 90 min) relative to parental mutant variant 12B8
Y179H
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 60 min) relative to parental mutant variant K7E3
Q192R
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 60 min) relative to parental mutant variant B1G6
-
Q192R/A46P/V159A
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 90 min) relative to parental mutant variant 16B7
-
Q192R/Y179H
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 90 min) relative to parental mutant variant 12B8
-
Y179H
-
site-directed mutagenesis, analysis of initial activity and thermostability (at 55°C, 60 min) relative to parental mutant variant K7E3
-
D50N
less than 0.1% of wild-type activity
H117A
less than 0.1% of wild-type activity
K84M
complete loss of activity
K84R
complete loss of activity
Y55F
narrow substrate specificity, reduction of selected aromatic quinones and alpha-dicarbonyls. The activation energy for 9,10-phenanthrenequinone reduction is unchanged in Y55 mutants
Y55S
narrow substrate specificity, reduction of selected aromatic quinones and alpha-dicarbonyls. The activation energy for 9,10-phenanthrenequinone reduction is unchanged in Y55 mutants
additional information