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1.6.3.3: NADH oxidase (H2O2-forming)

This is an abbreviated version!
For detailed information about NADH oxidase (H2O2-forming), go to the full flat file.

Word Map on EC 1.6.3.3

Reaction

NADH
+
H+
 +
O2
=
NAD+
 +
H2O2

Synonyms

AF0395, H2O2-forming NADH oxidase, H2O2-forming reduced nicotinamide adenine dinucleotide oxidase, MJ0649, MJNox, NADH:O2 oxidoreductase, NOX, Nox-1, NOX1, NoxA-1, NoxA2, NoxB-1, PH0311, PhNOX

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.3 NADH oxidase (H2O2-forming)

Inhibitors

Inhibitors on EC 1.6.3.3 - NADH oxidase (H2O2-forming)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-chloromercuribenzoate
0.1 mM, 40% inhibition
5,5'-dithiobis-(2-nitrobenzoate)
-
1 mM, 7 min, 50% loss of activity
AgNO3
-
1 mM, 63% inhibition
ascorbate
1 mM, 81% inhibition
Ba2+
0.1 mM, 86% inhibition
Ca2+
0.1 mM, about 20% inhibition
CaCl2
10 mM, slightly increases activity
Cd(CH3CH2COO-)2
10 mM, slightly increases activity
Co2+
0.1 mM, 31% inhibition
CoCl2
10 mM, slightly increases activity
Cr2+
0.1 mM, 49% inhibition
Cu2+
0.1 mM, complete inhibition
CuCl2
CuSO4
-
1 mM, 1 h at 22°C, 85% remaining activity
cysteine
1 mM, 54% inhibition
dithiothreitol
2 mM, rapid decrease in activity to less than 10% of the activity
EGTA
10 mM, slightly increases activity
Fe2+
0.1 mM, 56% inhibition
FeSO4
-
1 mM, 1 h at 22°C, 56% remaining activity
Guanidine-HCl
Hg2+
0.1 mM, complete inhibition
HgCl2
hydrocortisone
-
3 mM, 5% inhibition
MgCl2
-
1 mM, 1 h at 22°C, 93% remaining activity
Mn2+
0.1 mM, about 20% inhibition
MnCl2
10 mM, slightly increases activity
Ni2+
0.1 mM, 73% inhibition
NiCl2
-
1 mM, 1 h at 22°C, 71% remaining activity
Quinacrine
-
3 mM, 46% inhibition
Quinine
-
3 mM, 23% inhibition
SDS
0.5%, completely inhibits the reaction
Sn2+
0.1 mM, complete inhibition
sodium deoxycholate
0.5%, slightly decreases activity
Zn2+
0.1 mM, 53% inhibition
ZnCl2
ZnSO4
-
1 mM, 1 h at 22°C, 69% remaining activity