1.6.2.4: NADPH-hemoprotein reductase This is an abbreviated version! For detailed information about NADPH-hemoprotein reductase, go to the full flat file .
Reaction
NADPH +
oxidized hemoprotein =
NADP+ +
reduced hemoprotein +
H+
Synonyms 107366505, aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, NCP1, neotetrazolin reductase, NPR, NP_000932, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2
ECTree
Source Tissue
Source Tissue on EC 1.6.2.4 - NADPH-hemoprotein reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
brenda
-
-
brenda
-
brenda
dorsal
brenda
-
-
brenda
-
deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity
brenda
lowest expression in eggs
brenda
-
cement gland, lens placode, ear vesicle, mesencephalon, rhombencephalon, lymphatic vessel and heart anlage at stage 29
brenda
-
-
brenda
-
-
brenda
-
brenda
Corbula caribea
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
Corbula caribea
-
-
brenda
-
-
brenda
-
brenda
-
polymorphonuclear
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
type II lung epithelial cell
brenda
-
-
brenda
-
olfactory and respiratory mucosa
brenda
-
-
brenda
-
brenda
-
peritoneal
brenda
-
brenda
-
-
brenda
-
primary from mouse calvariae
brenda
-
-
brenda
-
the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
brenda
-
-
brenda
-
-
brenda
-
transfected with the human P450 Red gene
brenda
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
-
brenda
-
brenda
overexpression of TcCPR-B in Trypanosoma cruzi epimastigotes increases its resistance to the typical chemotherapeutic agents Nifurtimox and Benznidazole
brenda
-
brenda
-
brenda
-
brenda
-
of larvae of both sexes
brenda
-
brenda
high expression level
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
Coleus scutellarioides
-
-
brenda
-
the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
buds and nascent, open flowers
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
alpha-lipoic acid decreases enzyme activity in lung and heart
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
-
brenda
high expression level
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
Coleus scutellarioides
-
-
brenda
-
-
brenda
-
brenda
-
the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
NaCl application results in a significant increase in the activity
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
NaCl application results in a significant increase in the activity
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
brenda
-
phenobarbital-treated animals
brenda
-
-
brenda
-
phenobarbital-treated animals
brenda
-
3-methylcholantrene-treated animals
brenda
-
hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase
brenda
-
liver POR plays an important role regulating gene expression and lipid metabolism locally. The hepatic deficiency of this enzyme reverberates throughout the biological system and produces a coordinated response to the low levels of circulating cholesterol and bile
brenda
-
-
-
brenda
-
phenobarbital-treated animals
-
brenda
-
3-methylcholantrene-treated animals
-
brenda
-
-
brenda
-
-
288550 , 288571 , 288575 , 288577 , 288580 , 288585 , 288587 , 288590 , 288602 , 288616 , 288619 , 438257 , 671712 , 674672 , 686851 , 713542 , 742564 brenda
-
brenda
-
phenobarbital-treated animals
brenda
-
riboflavin-deficient animals
brenda
-
phenobarbital-treated animals
-
brenda
-
-
-
brenda
-
phenobarbital-treated animals
-
brenda
-
-
-
brenda
-
riboflavin-deficient animals
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
alpha-lipoic acid decreases enzyme activity in lung and heart
brenda
-
the numbers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumors are reduced in the lung-Cpr-null mice but are increased in the liver-Cpr-null mice, relative to wild-type control mice
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
of larvae of both sexes
brenda
-
brenda
-
brenda
-
brenda
-
-
brenda
-
of larvae of both sexes
brenda
-
of larvae, induction of larvae with pentamethylbenzene
brenda
-
brenda
high expression level
brenda
-
-
brenda
-
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
Coleus scutellarioides
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
Vicia faba, leek, sunflower
brenda
-
-
brenda
-
beta-naphtoflavone-treated animals
brenda
-
beta-naphtoflavone-treated animals
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
Coleus scutellarioides
-
-
brenda
-
the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
brenda
strongly expressed
brenda
additional information
expressed in all tissues examined
brenda
additional information
expressed in all tissues examined
brenda
additional information
-
expressed in all tissues examined
brenda
additional information
tissue- and developmental stage-dependent expression analysis of CsCPR mRNA by real-time quantitative PCR. The enzyme is exxpressed in the digestive, metabolic, and olfactory organs of the larvae and adults, overview
brenda
additional information
-
CPR activity in 28-day-old male offspring in only the LM76 group (low protein diet based on the modified version of the AIN76A purified diet) but not in the L93 group (low protein diet based on the AIN93G purified diet) is significantly greater than its purified control. CPR activity in 28-day-old male offspring of the M76 group is lower than that in the NP group (nonpurified diet). CPR activities in 65- and 150-day-old male offspring in all five groups are similar. CPR activities in 28-day-old female offspring of the LPD groups are similar to those of their respective purified control groups. However, CPR activities in 28-day-old female offspring in both the purified control groups are lower than that in the NP group. These differences disappeare by day 65, and the lack of differences persisted on day 150. Gender differences (activity in males greater than that in females) are present in all five groups on day 150 but not on days 28 and 65 (the 28-day-old NP group being an exception)
brenda
additional information
-
P450 enzyme expression patterns in adult and larval tissues, overview
brenda
additional information
protein is detected in all tested developmental stages and tissues, but highly expressed in third-, fourth-, and fifth-instar larvae, and in midgut and fat body
brenda
additional information
CPR is ubiquitously transcribed in different life stages of Tetranychus urticae, the highest transcription is observed in the nymph and adult stages
brenda
additional information
presence in every Trypanosoma cruzi developmental stage
brenda
additional information
presence in every Trypanosoma cruzi developmental stage
brenda
additional information
presence in every Trypanosoma cruzi developmental stage
brenda
additional information
-
presence in every Trypanosoma cruzi developmental stage
brenda
additional information
higher expression level of WsCPR2 in comparison to WsCPR1
brenda
additional information
higher expression level of WsCPR2 in comparison to WsCPR1
brenda
additional information
-
higher expression level of WsCPR2 in comparison to WsCPR1
brenda