Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.6.2.2: cytochrome-b5 reductase

This is an abbreviated version!
For detailed information about cytochrome-b5 reductase, go to the full flat file.

Word Map on EC 1.6.2.2

Reaction

NADH
+ 2 ferricytochrome b5 =
NAD+
 +
H+
 + 2 ferrocytochrome b5

Synonyms

b5 plusb5R, b5/b5R, B5R, cb5r, CBR, CBR1, CBR1A, CBR1B, CyB5R, CYB5R2, CYB5R3, Cyb5R4, cyt b5r, cyt b5R protein, cytochrome b5 reductase, cytochrome b5 reductase 2, cytochrome b5 reductase 3, DIA1, diaphorase I, dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase, HPO-19, methemoglobin reductase, NADH cytochrome b5 oxidoreductase, NADH cytochrome B5 reductase, NADH-b5R, NADH-cytochrome b 5 reductase, NADH-cytochrome b5 reductase, NADH-cytochrome b5 reductase 3, NADH-cytochrome-b5 reductase, NADH-cytochrome-b5 reductase 3, NADH-dependent cytochrome b5 reductase, NADH-ferricyanide reductase, NADH-ferricytochrome b5 oxidoreductase, NADH-ferricytochrome reductase, NADH: ferricytochrome b5 oxidoreductase, NADH:cytochrome b5 reductase, NADH:ferricytochrome b5 oxidoreductase, Ncb5or, P34/P32, P35, reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase, reductase, cytochrome b5, T05H4.4

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.2 With a heme protein as acceptor
                1.6.2.2 cytochrome-b5 reductase

Inhibitors

Inhibitors on EC 1.6.2.2 - cytochrome-b5 reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-catechin
-
-
(+)-taxifolin
-
-
(-)-epicatechin
-
-
(5Z)-5-[(9H-fluoren-3-yl)methylidene]-1-(4-methylphenyl)-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione
about 80% inhibition at 0.5 mM
(5Z)-5-{[4-bromo-5-(morpholin-4-yl)furan-2-yl]methylidene}-1-(4-methylphenyl)-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione
about 5% inhibition at 0.5 mM
1,10-phenanthroline
-
-
1-(2-fluorophenyl)-5-[(1-methyl-2,3-dihydro-1H-indol-3-yl)methyl]-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione
about 75% inhibition at 0.5 mM
2,2'-dipyridyl
-
-
2-methyl-6-[(phenylsulfanyl)methyl]-2,5-dihydropyrimidin-4(3H)-one
about 5% inhibition at 0.5 mM
4-({[(2S)-2,3-dihydro-1,3-benzoxazol-2-yl]sulfanyl}methyl)tetrahydropyrimidine-2,5-dione
about 45% inhibition at 0.5 mM
5'-(p-fluorosulfonylbenzoyl)-adenosine
-
-
5-(prop-2-en-1-yl)-6-propyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
about 75% inhibition at 0.5 mM
5-propyl-2-thiouracil
-
25 mM, almost complete inhibition
6-(pentyloxy)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
about 25% inhibition at 0.05 mM
6-([[(2R)-2,3-dihydro-1,3-benzoxazol-2-yl]sulfanyl]methyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
complete inhibition at 0.05 mM
6-benzyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
about 3% inhibition at 0.5 mM
6-pentyl-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
about 25% inhibition at 0.5 mM
6-Propyl-2-thiouracil
-
about 20% residual activity at 0.009 mM
6-[(phenylsulfanyl)methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
complete inhibition at 0.05 mM
6-[(phenylsulfanyl)methyl]pyrimidine-2,4(1H,3H)-dione
about 50% inhibition at 0.5 mM
6-{[(2,6-dichlorophenyl)sulfanyl]methyl}-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
complete inhibition at 0.05 mM
6-{[(4-bromophenyl)sulfanyl]methyl}-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
about 10% inhibition at 0.05 mM
6-{[(4-methylphenyl)sulfanyl]methyl}-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
about 85% inhibition at 0.05 mM
6-{[(propan-2-yl)sulfanyl]methyl}-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
about 18% inhibition at 0.05 mM
acetate
-
-
Acrynol
adenine nucleotides
apigenin
-
-
apocynin
-
90.1% inhibition at 0.2 mM
Atebrin
benzoate
-
complete inhibition at 1 mM
benzyl alcohol
-
100 mM, 52% inhibition, reversible, may be due to changes in membrane fluidity
Br-
-
competitive vs. cytochrome b5, reversible by dilution
Ca2+
-
23.5% residual activity at 1 mM
CaCl2
-
8 mM, 50% inhibition, competitive vs. cytochrome b5
citrate
-
-
dicoumarol
dithiothreitol
-
80% residual activity at 1 mM
ebselen
-
almost complete inhibition at 0.02 mM
F-
-
competitive vs. cytochrome b5, reversible by dilution
hemin
-
-
I-
-
competitive vs cytochrome b5, reversible by dilution
Inositol hexaphosphate
-
-
iodoacetamide
iodoacetate
-
27.3% residual activity at 1 mM
iodoacetic acid
-
5 mM, complete inhibition
K+ high ionic strength
-
luteolin
-
-
luteolin-7-O-glucoside
-
-
Mepacrin
-
-
Mersalyl
-
complete inhibition at 1.0 mM
MgCl2
-
78.1 mM, 50% inhibition, competitive vs. cytochrome b5
morin
-
-
myricetin
N-ethylmaleimide
NaCN
-
91.4% residual activity at 1 mM
nitric oxide
-
-
p-chloromercuribenzoate
p-hydroxymercuribenzoate
para-chloromercuribenzenesulfonate
-
Pentachlorophenol
-
-
peroxynitrite
-
-
phosphate
-
competitive inhibition
Phytohemagglutinin
-
-
-
Proflavin
propylthiouracil
complete inhibition at 0.5 mM
quercetin
quercitrin
-
-
rutin
-
-
succinate
-
-
taurodeoxycholate
Thenoyltrifluoroacetone
-
-
Tris
-
reduction of cytochrome b5
Wheat germ agglutinin
-
-
-
ZINC39395747
-
-
additional information
-