1.5.5.1: electron-transferring-flavoprotein dehydrogenase
This is an abbreviated version!
For detailed information about electron-transferring-flavoprotein dehydrogenase, go to the full flat file.
Word Map on EC 1.5.5.1
-
1.5.5.1
-
acyl-coa
-
riboflavin
-
glutaric
-
dehydrogenases
-
flavin
-
myopathy
-
late-onset
-
carnitine
-
dehydrogenation
-
acylcarnitine
-
acidemia
-
riboflavin-responsive
-
beta-oxidation
-
semiquinone
-
acyl-coenzyme
-
butyryl-coa
-
paracoccus
-
isovaleryl-coa
-
glutaryl-coa
-
ethylmalonic
-
medicine
- 1.5.5.1
- acyl-coa
- riboflavin
-
glutaric
- dehydrogenases
- flavin
- myopathy
-
late-onset
- carnitine
-
dehydrogenation
- acylcarnitine
- acidemia
-
riboflavin-responsive
-
beta-oxidation
- semiquinone
-
acyl-coenzyme
- butyryl-coa
- paracoccus
- isovaleryl-coa
- glutaryl-coa
-
ethylmalonic
- medicine
Reaction
Synonyms
BCAL1468, BCAS0609, electron flavoprotein reductase, electron transfer flavoprotein, electron transfer flavoprotein dehydrogenase, electron transfer flavoprotein Q oxidoreductase, electron transfer flavoprotein ubiquinone oxidoreductase, electron transfer flavoprotein-ubiquinone oxidoreductase, electron transfer flavoprotein: ubiquinone oxidoreductase, electron transfer flavoprotein:ubiquinone oxidoreductase, electron-transfer flavoprotein-2,3-dimethoxy-5-methyl-1,4-benzoquinone oxidoreductase, electron-transfer flavoprotein-ubiquinone oxidoreductase, electron-transfer flavoprotein:ubiquinone oxidoreductase, electron-transferring flavoprotein dehydrogenase, Electron-transferring-flavoprotein dehydrogenase, ETF dehydrogenase, ETF-QO, ETF-ubiquinone oxidoreductase, ETF:QO, ETF:quinone oxidoreductase, ETF:ubiquinone oxidoreductase, EtfA2, ETFDH, ETFDH1, ETFDH2, ETFQO, let-721
ECTree
1.5.5.1 electron-transferring-flavoprotein dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.5.5.1 - electron-transferring-flavoprotein dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
electron-transferring flavoprotein + hydroquinone electron transferring flavoprotein + ubiquinol
semiquinone electron transferring flavoprotein + ubiquinone
-
-
-
-
r
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-pentyl-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-pentyl-1,4-benzoquinol
-
-
-
r
reduced electron-transferring flavoprotein + 2,6-dichloroindophenol
electron-transferring flavoprotein + reduced 2,6-dichloroindophenol
reduced electron-transferring flavoprotein + 6-(10-bromodecyl)ubiquinone
electron-transferring flavoprotein + 6-(10-bromodecyl)ubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + 6-(10-hydroxydecyl)ubiquinone
electron-transferring flavoprotein + 6-(10-hydroxydecyl)ubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + 6-heptylubiquinone
electron-transferring flavoprotein + 6-heptylubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + 6-nonylubiquinone
electron-transferring flavoprotein + 6-nonylubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + coenzyme Q1
electron-transferring flavoprotein + reduced coenzyme Q1
reduced electron-transferring flavoprotein + decylubiquinone
electron-transferring flavoprotein + decylubiquinol
-
-
-
-
?
reduced electron-transferring flavoprotein + nitro blue tetrazolium
electron transferring-flavoprotein + reduced nitro blue tetrazolium
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
reduced electron-transferring flavoprotein + ubiquinone-2
electron-transferring flavoprotein + ubiquinol-2
reduced electron-transferring flavoprotein + ubiquinone-4
electron-transferring flavoprotein + ubiquinol-4
-
-
-
-
?
reduced electron-transferring flavoprotein-4'-deoxy-FAD + ubiquinone-1
electron-transferring flavoprotein-4'-deoxy-FAD + ubiquinol-1
-
0.07% of turnover with native electron-transferring flavoprotein
-
?
reduced electron-transferring-flavoprotein + 2,5-dibromo-3-methyl-6-isopropyl-4-benzoquinone
electron-transferring-flavoprotein + 2,5-dibromo-3-methyl-6-isopropyl-4-benzoquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + 6-bis(isoprenyl)ubiquinone
electron-transferring-flavoprotein + 6-bis(isoprenyl)ubiquinol
-
optimal ubiquinone derivative
-
-
?
reduced electron-transferring-flavoprotein + 6-isoprenylubiquinone
electron-transferring-flavoprotein + 6-isoprenylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + bromodecylubiquinone
electron-transferring-flavoprotein + bromodecylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + decylubiquinone
electron-transferring-flavoprotein + decylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + duroquinone
electron-transferring-flavoprotein + duroquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + heptylubiquinone
electron-transferring-flavoprotein + heptylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + hydroxydecylubiquinone
electron-transferring-flavoprotein + hydroxydecylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + menadione
electron-transferring-flavoprotein + menadiol
-
-
-
-
?
reduced electron-transferring-flavoprotein + nonylubiquinone
electron-transferring-flavoprotein + nonylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + pentadecylubiquinone
electron-transferring-flavoprotein + pentadecylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + tridecylubiquinone
electron-transferring-flavoprotein + tridecylubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + ubiquinone
electron-transferring-flavoprotein + ubiquinol
semiquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + hydroquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
semiquinone electron transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + hydroquinone electron transferring flavoprotein + ubiquinol
-
-
-
-
r
semiquinone electron transferring flavoprotein + ubiquinone Q1
electron-transferring flavoprotein + hydroquinone electron transferring flavoprotein + ubiquinol Q1
-
-
-
-
r
semiquinone electron-transferring flavoprotein + ubiquinone Q1
electron-transferring flavoprotein + hydroquinone electron-transferring flavoprotein + ubiquinol Q1
-
-
-
-
r
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
-
-
?
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
trivial name ubiquinone-1, enzyme is an efficient electron acceptor for electron-transferring flavoprotein and a reductase of ubiqinone
-
?
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
-
-
?
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
pig liver or Paracoccus denitrificans electron-transferring flavoprotein as electron carrier
-
?
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
-
-
?
reduced electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
-
-
?
reduced electron-transferring flavoprotein + 2,6-dichloroindophenol
electron-transferring flavoprotein + reduced 2,6-dichloroindophenol
-
-
-
?
reduced electron-transferring flavoprotein + 2,6-dichloroindophenol
electron-transferring flavoprotein + reduced 2,6-dichloroindophenol
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
?
reduced electron-transferring flavoprotein + 2,6-dichloroindophenol
electron-transferring flavoprotein + reduced 2,6-dichloroindophenol
-
-
-
?
reduced electron-transferring flavoprotein + coenzyme Q1
electron-transferring flavoprotein + reduced coenzyme Q1
-
-
-
?
reduced electron-transferring flavoprotein + coenzyme Q1
electron-transferring flavoprotein + reduced coenzyme Q1
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
?
reduced electron-transferring flavoprotein + coenzyme Q1
electron-transferring flavoprotein + reduced coenzyme Q1
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
Agrobacterium tumefaciens C58 / ATCC 33970
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
group I electron-transferring flavoprotein, ETF
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
group I electron-transferring flavoprotein, ETF
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
electron transfer via flavin cofactor
-
-
r
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
via FAD
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
via FAD
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
electron-transferring flavoprotein alpha- and beta-subunits contain a FAD cofactor and an AMP molecule, respectively
-
-
?
reduced electron-transferring flavoprotein + ubiquinone
electron-transferring flavoprotein + ubiquinol
-
electron transfer via flavin cofactor
-
-
r
reduced electron-transferring flavoprotein + ubiquinone-2
electron-transferring flavoprotein + ubiquinol-2
-
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone-2
electron-transferring flavoprotein + ubiquinol-2
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone-2
electron-transferring flavoprotein + ubiquinol-2
-
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone-2
electron-transferring flavoprotein + ubiquinol-2
-
-
-
?
reduced electron-transferring flavoprotein + ubiquinone-2
electron-transferring flavoprotein + ubiquinol-2
-
-
-
-
?
reduced electron-transferring-flavoprotein + ubiquinone
electron-transferring-flavoprotein + ubiquinol
-
-
-
-
?
reduced electron-transferring-flavoprotein + ubiquinone
electron-transferring-flavoprotein + ubiquinol
-
ETF is the intermediate electron carrier between dehydrogenases and the enzyme, enzyme mediates between eleven mitochondrial proteins and the ubiquinone pool
-
-
?
reduced electron-transferring-flavoprotein + ubiquinone
electron-transferring-flavoprotein + ubiquinol
-
ubiquinone is 2,3-dimethoxy-5-methyl-1,4-benzoquinone
-
-
?
semiquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + hydroquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
-
-
?
semiquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + hydroquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
-
-
?
semiquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinone
electron-transferring flavoprotein + hydroquinone electron transferring flavoprotein + 2,3-dimethoxy-5-methyl-6-(3-methylbut-2-en)-1,4-benzoquinol
-
disproportion and comproportion with ubiqinone-1 as the terminal oxidant
-
r
additional information
?
-
although Agrobacterium tumefaciens ETF-mediated electron transfer to 2,6-DCIP is observed with a number of different dehydrogenases, the reduction of coenzyme Q1 through the DH/ETF/ETF-QO system is only observed with dimethylglycine dehydrogenase, but not with any of the tested Agrobacterium tumefaciens acyl-CoA dehydrogenases
-
-
?
additional information
?
-
-
although Agrobacterium tumefaciens ETF-mediated electron transfer to 2,6-DCIP is observed with a number of different dehydrogenases, the reduction of coenzyme Q1 through the DH/ETF/ETF-QO system is only observed with dimethylglycine dehydrogenase, but not with any of the tested Agrobacterium tumefaciens acyl-CoA dehydrogenases
-
-
?
additional information
?
-
Agrobacterium tumefaciens C58 / ATCC 33970
although Agrobacterium tumefaciens ETF-mediated electron transfer to 2,6-DCIP is observed with a number of different dehydrogenases, the reduction of coenzyme Q1 through the DH/ETF/ETF-QO system is only observed with dimethylglycine dehydrogenase, but not with any of the tested Agrobacterium tumefaciens acyl-CoA dehydrogenases
-
-
?
additional information
?
-
-
assay method uses dichlorophenolindophenol, DCPIP, as substrate
-
-
?
additional information
?
-
enzyme deficiency leads to glutaric acidemia type II
-
-
?
additional information
?
-
-
enzyme deficiency leads to glutaric acidemia type II
-
-
?
additional information
?
-
-
specificity for different ubiquinone derivatives, overview
-
-
?
additional information
?
-
-
the electron-transferring flavoprotein beta-D128N mutation occurs in a beta-turn located near the AMP binding site, a region that is involved in intersubunit contacts and establishes outer-sphere interactions with the FAD cofactor, namely at the level of the isoalloxazine moiety. Namely ETF b-D128N and ETF b-R191C,would have an impacton reactive oxygen species generation.The ETF variants show about 70% decreased activity in comparison with the wild-type protein, and establish a rationale for their functional defects
-
-
?
additional information
?
-
the recombinant human enzyme is able to transfer electrons from the ETF protein from Agrobacterium tumefaciens strain C58 to 2,6-dichloroindophenol or coenzyme Q1 in an in vitro system
-
-
?
additional information
?
-
-
the recombinant human enzyme is able to transfer electrons from the ETF protein from Agrobacterium tumefaciens strain C58 to 2,6-dichloroindophenol or coenzyme Q1 in an in vitro system
-
-
?
additional information
?
-
-
mechanism of superoxide formation by ETF-QO, reduction potentials of redox centres, overview
-
-
?
