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1.5.3.5: (S)-6-hydroxynicotine oxidase

This is an abbreviated version!
For detailed information about (S)-6-hydroxynicotine oxidase, go to the full flat file.

Word Map on EC 1.5.3.5

Reaction

(S)-6-hydroxynicotine
+
H2O
+
O2
=
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one
+
H2O2

Synonyms

6-HLNO, 6-hydroxy-L-nicotine oxidase, 6-hydroxy-L-nicotine:oxygen oxidoreductase, 6HLNO, flavoprotein nicotine oxidoreductase, L-6-hydroxynicotine oxidase, LHNO, MAO, NdpB, NicA2, NOX, VppB

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.5 (S)-6-hydroxynicotine oxidase

Inhibitors

Inhibitors on EC 1.5.3.5 - (S)-6-hydroxynicotine oxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-hydroxy-D-nicotine
Ag+
1 mM, about 85% inhibition
Co2+
1 mM, about 10% inhibition
Cu2+
1 mM, about 85% inhibition
DL-2-hydroxynicotine
-
-
EDTA
incubation for 1 h completely inhibits enzymatic activity
Hg2+
1 mM, about 80% inhibition
HgCl2
-
100% inhibition at 0.005 mM
methylene blue
-
strong inhibitor
Na2MoO4
-
12% inhibition at 0.05 mM
o-phenanthroline
-
69% inhibition at 9 mM
p-chloromercuriphenylsulfonate
-
60% inhibition at 0.025 mM, inhibition can be reversed by an excess of thiol compounds
SDS
incubation for 1 h completely inhibits enzymatic activity
Urea
-
at 4 M, 38% inhibition and at 7.2 M, 93% inhibition
Zn2+
1 mM, about 25% inhibition
ZnSO4
-
57% inhibition at 0.05 mM