1.5.3.16: spermine oxidase
This is an abbreviated version!
For detailed information about spermine oxidase, go to the full flat file.
Word Map on EC 1.5.3.16
-
1.5.3.16
-
polyamine
-
putrescine
-
acetylpolyamine
-
back-conversion
-
n1-acetylspermine
-
n1-acetylpolyamine
-
3-aminopropanal
-
acrolein
-
benspm
-
medicine
- 1.5.3.16
- polyamine
- putrescine
-
acetylpolyamine
-
back-conversion
- n1-acetylspermine
-
n1-acetylpolyamine
- 3-aminopropanal
- acrolein
-
benspm
- medicine
Reaction
Synonyms
AtPAO1, AtPAO4, AtPAO5, EC 1.5.3.11, Fms1 protein, GhPAO, hSMO, MmSMO, mSMO, mSMOalpha, mSMOmu, PAO, PAO1, PAO4, PAO5, PAO6, PAO7, PAOh1, PAOh1/SMO, SelPAO5, SMO, SMO(PAOh1), SMO/PAOh1, SMO5, SMOX, spermine oxidase, Spm oxidase, thermospermine oxidase
ECTree
1.5.3.16 spermine oxidaseAdvanced search results
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Reference on EC 1.5.3.16 - spermine oxidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, Y.; Devereux, W.; Woster, P.M.; Stewart, T.M.; Hacker, A.; Casero, R.A., Jr.
Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure
Cancer Res.
61
5370-5373
2001
Homo sapiens (Q9NWM0)
Landry, J.; Sternglanz, R.
Yeats Fms1 is a FAD-utilizing polyamine oxidase
Biochem. Biophys. Res. Commun.
303
771-776
2003
Saccharomyces cerevisiae
Wang, Y.; Murray-Stewart, T.; Devereux, W.; Hacker, A.; Frydman, B.; Woster, P.M.; Casero, R.A.Jr.
Properties of purified human polyamine oxidase, PAOh1/SMO
Biochem. Biophys. Res. Commun.
304
605-611
2003
Homo sapiens (Q9NWM0), Homo sapiens
Bianchi, M.; Polticelli, F.; Ascenzi, P.; Botta, M.; Federico, R.; Mariottini, P.; Cona, A.
Inhibition of polyamine and spermine oxidases by polyamine analogues
FEBS J.
273
1115-1123
2006
Mus musculus
Tavladoraki, P.; Rossi, M.N.; Saccuti, G.; Perez-Amador, M.A.; Polticelli, F.; Angelini, R.; Federico, R.
Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion
Plant Physiol.
141
1519-1532
2006
Arabidopsis thaliana (Q9FNA2)
Bellelli, A.; Cavallo, S.; Nicolini, L.; Cervelli, M.; Bianchi, M.; Mariottini, P.; Zelli, M.; Federico, R.
Mouse spermine oxidase: a model of the catalytic cycle and its inhibition by N,N1-bis(2,3-butadienyl)-1,4-butanediamine
Biochem. Biophys. Res. Commun.
322
1-8
2004
Mus musculus (Q99K82), Mus musculus
Müller, S.; Walter, R.D.
Purification and characterization of polyamine oxidase from Ascaris suum
Biochem. J.
1283
75-80
1992
Ascaris suum
Vujcic, S.; Diegelman, P.; Bacchi, C.J.; Kramer, D.L.; Porter, C.W.
Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin
Biochem. J.
367
665-675
2002
Mus musculus (Q99K82), Mus musculus, Homo sapiens (Q9NWM0), Homo sapiens
Wang, Y.; Hacker, A.; Murray-Stewart, T.; Fleischer, J.G.; Woster, P.M.
Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein
Biochem. J.
386
543-547
2005
Homo sapiens
Amendolaa, R.; Bellini, A.; Cervelli, M.; Deganc, P.; Marcoccid, L.; Martinie, F.; Mariottini, P.
Direct oxidative DNA damage, apoptosis and radio sensitivity by spermine oxidase activities in mouse neuroblastoma cells
Biochim. Biophys. Acta
1755
15-24
2005
Mus musculus (Q99K82), Mus musculus
Bianchi, M.; Bellini, A.; Cervelli, M.; Degan, P.; Narcocci, L.; Martini, F; Scatteia, M.; Mariottini, P.; Amendola, R.
Chronic sub-lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to radiation exposure
Biochim. Biophys. Acta
1773
774-783
2007
Mus musculus
Babbar, N.; Casero, R.A.
Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis
Cancer Res.
66
11125-11130
2006
Homo sapiens
Cervelli, M.; Bellini, A.; Bianchi, M.; Marcocci, L.; Nocera, S.; Polticelli, F.; Federico, R.; Amendola, R.; Mariottini, P.
Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform
Eur. J. Biochem.
760
760-770
2004
Mus musculus (Q99K82), Mus musculus
Bianchi, M.; Amendola, R.; Federico, R.; Polticelli, F.; Mariottin, P.
Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase mu isoform
FEBS J.
272
3052-3059
2005
Mus musculus (Q99K82), Mus musculus
Murray-Stewart, T.; Wang, Y.; Goodwin, A.; Hacker A.; Meeker, A.; casero, R.A.
Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology
FEBS J.
275
2795-2806
2008
Homo sapiens, Homo sapiens (Q9NWM0)
Cervelli, M.; Fratini, E.; Amendola, A.; Bianchi, M.; Signori, E.; Ferraro, E.; Lisi, A.; Federico, R.; Marcocci, L.; Mariottini, P.
Increased spermine oxidase (SMO) activity as a novel differentiation marker of myogenic C2C12 cells
Int. J. Biochem. Cell Biol.
41
934-944
2009
Mus musculus
Cervelli, M.; Polticelli, F.; Federico, R.; Mariottini, P.
Heterologous expression and characterization of mouse spermine oxidase
J. Biol. Chem.
278
5271-5276
2003
Mus musculus (Q99K82), Mus musculus
Pledgie, A.; Huang, Y.; Hacker, A.; Zhang, Z.; Woster, P.M.; Davidson, N.E.; Casero, R.A.
Spermine oxidase SMO(PAOh1), not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines
J. Biol. Chem.
280
39843-39851
2005
Homo sapiens
Järvinen, A.; Grigorenko, N.; Khomutov, A.R.; Hyvönen, M.T.; Uimari, A.; Vepsäläinen, J.; Sinervirta, R.; Keinänen, T.A.; Vujcic, S.; Alhonen, L.; Porter, C.W.; Jänne, J.
Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines.
J. Biol. Chem.
280
6595-6601
2005
Homo sapiens
Müller, S.; Hunter, K.J.; Walter, R.D.
Effect of haloallylamines on polyamine oxidase activity and spermine levels in Ascaris suum
Parasitol. Res.
82
571-573
1996
Ascaris suum
Kamada-Nobusada, T.; Hayashi, M.; Fukazawa, M.; Sakakibara, H.; Nishimura, M.
A putative peroxisomal polyamine oxidase, AtPAO4, is involved in polyamine catabolism in Arabidopsis thaliana
Plant Cell Physiol.
49
1272-1282
2008
Arabidopsis thaliana (Q8H191)
Goodwin, A.C.; Jadallah, S.; Toubaji, A.; Lecksell, K.; Hicks, J.L.; Kowalski, J.; Bova, G.S.; de Marzo, A.M.; Netto, G.J.; Casero, R.A.
Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues
Prostate
68
766-772
2008
Homo sapiens
Tavladoraki, P.; Cervelli, M.; Antonangeli, F.; Minervini, G.; Stano, P.; Federico, R.; Mariottini, P.; Polticelli, F.
Probing mammalian spermine oxidase enzyme-substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization
Amino Acids
40
1115-1126
2011
Mus musculus, Mus musculus (Q99K82)
Adachi, M.S.; Juarez, P.R.; Fitzpatrick, P.F.
Mechanistic studies of human spermine oxidase: kinetic mechanism and pH effects
Biochemistry
49
386-392
2010
Homo sapiens
Cervelli, M.; Bellavia, G.; Fratini, E.; Amendola, R.; Polticelli, F.; Barba, M.; Federico, R.; Signore, F.; Gucciardo, G.; Grillo, R.; Woster, P.; Casero Jr, R.; Mariottini, P.
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
BMC Cancer
10
555
2010
Homo sapiens, Mus musculus
Fiori, L.M.; Turecki, G.
Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers
Int. J. Neuropsychopharmacol.
13
725-736
2010
Homo sapiens
Stanic, I.; Facchini, A.; Borzi, R.; Stefanelli, C.; Flamigni, F.
The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines
J. Cell. Physiol.
219
109-116
2009
Homo sapiens
Fincato, P.; Moschou, P.N.; Spedaletti, V.; Tavazza, R.; Angelini, R.; Federico, R.; Roubelakis-Angelakis, K.A.; Tavladoraki, P.
Functional diversity inside the Arabidopsis polyamine oxidase gene family
J. Exp. Bot.
6
1155-1168
2010
Arabidopsis thaliana (Q8H191), Arabidopsis thaliana (Q9FNA2), Arabidopsis thaliana
Takahashi, Y.; Cong, R.; Sagor, G.H.; Niitsu, M.; Berberich, T.; Kusano, T.
Characterization of five polyamine oxidase isoforms in Arabidopsis thaliana
Plant Cell Rep.
29
955-965
2010
Arabidopsis thaliana (Q8H191), Arabidopsis thaliana (Q9FNA2), Arabidopsis thaliana
Häkkinen, M.; Hyönen, M.; Auriola, S.; Casero Jr., R.; Vepsäläinen, J.; Khomutov, A.; Alhonen, L.; Keinänen, T.
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases
Amino Acids
38
369-381
2010
Homo sapiens
Cervelli, M.; Amendola, R.; Polticelli, F.; Mariottini, P.
Spermine oxidase: ten years after
Amino Acids
42
441-450
2012
Homo sapiens, Mus musculus
Fincato, P.; Moschou, P.N.; Ahou, A.; Angelini, R.; Roubelakis-Angelakis, K.A.; Federico, R.; Tavladoraki, P.
The members of Arabidopsis thaliana PAO gene family exhibit distinct tissue- and organ-specific expression pattern during seedling growth and flower development
Amino Acids
42
831-841
2012
Arabidopsis thaliana
Moriya, S.; Iwasaki, K.; Samejima, K.; Takao, K.; Kohda, K.; Hiramatsu, K.; Kawakita, M.
A mass spectrometric method to determine activities of enzymes involved in polyamine catabolism
Anal. Chim. Acta
748
45-52
2012
Homo sapiens
Takao, K.; Shirahata, A.; Samejima, K.; Casero, R.A.; Igarashi, K.; Sugita, Y.
Pentamines as substrate for human spermine oxidase
Biol. Pharm. Bull.
36
407-411
2013
Homo sapiens
Capone, C.; Cervelli, M.; Angelucci, E.; Colasanti, M.; Macone, A.; Mariottini, P.; Persichini, T.
A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity
Free Radic. Biol. Med.
63
99-107
2013
Homo sapiens
Hong, S.K.; Chaturvedi, R.; Piazuelo, M.B.; Coburn, L.A.; Williams, C.S.; Delgado, A.G.; Casero, R.A.; Schwartz, D.A.; Wilson, K.T.
Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity
Inflamm. Bowel Dis.
16
1557-1566
2010
Homo sapiens
Fincato, P.; Moschou, P.N.; Spedaletti, V.; Tavazza, R.; Angelini, R.; Federico, R.; Roubelakis-Angelakis, K.A.; Tavladoraki, P.
Functional diversity inside the Arabidopsis polyamine oxidase gene family
J. Exp. Bot.
62
1155-1168
2011
Arabidopsis thaliana, Arabidopsis thaliana Columbia-0
Cervelli, M.; Salvi, D.; Polticelli, F.; Amendola, R.; Mariottini, P.
in the evolutionary framework of spermine oxidase
J. Mol. Evol.
76
365-370
2013
Homo sapiens, vertebrata, Mus musculus (Q99K82)
Bongers, K.S.; Fox, D.K.; Kunkel, S.D.; Stebounova, L.V.; Murry, D.J.; Pufall, M.A.; Ebert, S.M.; Dyle, M.C.; Bullard, S.A.; Dierdorff, J.M.; Adams, C.M.
Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy
Am. J. Physiol. Endocrinol. Metab.
308
E144-E158
2015
Mus musculus (Q99K82), Mus musculus
Chaturvedi, R.; Asim, M.; Barry, D.P.; Frye, J.W.; Casero, R.A.; Wilson, K.T.
Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori enhancement of antimicrobial nitric oxide generation by depletion of spermine
Amino Acids
46
531-542
2014
Mus musculus (Q99K82), Mus musculus, Homo sapiens (Q9NWM0), Homo sapiens
Cervelli, M.; Leonetti, A.; Cervoni, L.; Ohkubo, S.; Xhani, M.; Stano, P.; Federico, R.; Polticelli, F.; Mariottini, P.; Agostinelli, E.
Stability of spermine oxidase to thermal and chemical denaturation comparison with bovine serum amine oxidase
Amino Acids
48
2283-2291
2016
Mus musculus (Q99K82)
Cervelli, M.; Angelucci, E.; Stano, P.; Leboffe, L.; Federico, R.; Antonini, G.; Mariottini, P.; Polticelli, F.
The Glu216/Ser218 pocket is a major determinant of spermine oxidase substrate specificity
Biochem. J.
461
453-459
2014
Mus musculus (Q99K82)
Moriya, S.S.; Miura, T.; Takao, K.; Sugita, Y.; Samejima, K.; Hiramatsu, K.; Kawakita, M.
Development of irreversible inactivators of spermine oxidase and N1-acetylpolyamine oxidase
Biol. Pharm. Bull.
37
475-480
2014
Homo sapiens (Q9NWM0), Homo sapiens
Sagor, G.H.; Inoue, M.; Kim, D.W.; Kojima, S.; Niitsu, M.; Berberich, T.; Kusano, T.
The polyamine oxidase from lycophyte Selaginella lepidophylla (SelPAO5), unlike that of angiosperms, back-converts thermospermine to norspermidine
FEBS Lett.
589
3071-3078
2015
Selaginella lepidophylla (A0A0M3VGH5)
Ceci, R.; Duranti, G.; Leonetti, A.; Pietropaoli, S.; Spinozzi, F.; Marcocci, L.; Amendola, R.; Cecconi, F.; Sabatini, S.; Mariottini, P.; Cervelli, M.
Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression Evaluation of a new transgenic mouse model
Free Radic. Biol. Med.
103
216-225
2017
Mus musculus (Q99K82), Mus musculus
Bonaiuto, E.; Grancara, S.; Martinis, P.; Stringaro, A.; Colone, M.; Agostinelli, E.; Macone, A.; Stevanato, R.; Vianello, F.; Toninello, A.; Di Paolo, M.L.
A novel enzyme with spermine oxidase properties in bovine liver mitochondria identification and kinetic characterization
Free Radic. Biol. Med.
81
88-99
2015
Bos taurus
Tavladoraki, P.; Cona, A.; Angelini, R.
Copper-containing amine oxidases and FAD-dependent polyamine oxidases are key players in plant tissue differentiation and organ development
Front. Plant Sci.
7
824
2016
Arabidopsis thaliana (Q8H191), Arabidopsis thaliana (Q9FNA2)
Cervelli, M.; Polticelli, F.; Fiorucci, L.; Angelucci, E.; Federico, R.; Mariottini, P.
Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine
J. Enzyme Inhib. Med. Chem.
28
463-467
2013
Mus musculus (Q99K82)
-
Ahou, A.; Martignago, D.; Alabdallah, O.; Tavazza, R.; Stano, P.; Macone, A.; Pivato, M.; Masi, A.; Rambla, J.L.; Vera-Sirera, F.; Angelini, R.; Federico, R.; Tavladoraki, P.
A plant spermine oxidase/dehydrogenase regulated by the proteasome and polyamines
J. Exp. Bot.
65
1585-1603
2014
Arabidopsis thaliana (Q9SU79)
Hou, Z.; Liu, G.; Hou, L.; Wang, L.; Liu, X.
Regulatory function of polyamine oxidase-generated hydrogen peroxide in ethylene-induced stomatal closure in Arabidopsis thaliana
J. Integr. Agric.
12
251-262
2013
Arabidopsis thaliana (Q8H191)
-
Mo, H.; Wang, X.; Zhang, Y.; Zhang, G.; Zhang, J.; Ma, Z.
Cotton polyamine oxidase is required for spermine and camalexin signalling in the defence response to Verticillium dahliae
Plant J.
83
962-975
2015
Gossypium hirsutum
Kim, D.W.; Watanabe, K.; Murayama, C.; Izawa, S.; Niitsu, M.; Michael, A.J.; Berberich, T.; Kusano, T.
Polyamine oxidase 5 regulates Arabidopsis growth through Thermospermine oxidase activity
Plant Physiol.
165
1575-1590
2014
Arabidopsis thaliana (Q9SU79)
Leonetti, A.; Baroli, G.; Fratini, E.; Pietropaoli, S.; Marcoli, M.; Mariottini, P.; Cervelli, M.
Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase
Amino Acids
52
129-139
2020
Mus musculus (Q99K82), Mus musculus
Leonetti, A.; Cervoni, L.; Polticelli, F.; Kanamori, Y.; Yurtsever, Z.N.; Agostinelli, E.; Mariottini, P.; Stano, P.; Cervelli, M.
Spectroscopic and calorimetric characterization of spermine oxidase and its association forms
Biochem. J.
474
4253-4268
2017
Homo sapiens (Q9NWM0), Homo sapiens
Hu, T.; Sun, D.; Zhang, J.; Xue, R.; Janssen, H.L.A.; Tang, W.; Dong, L.
Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma
Hepatol. Res.
48
967-977
2018
Homo sapiens (Q9NWM0), Homo sapiens
Reinoso-Sanchez, J.F.; Baroli, G.; Duranti, G.; Scaricamazza, S.; Sabatini, S.; Valle, C.; Morlando, M.; Casero, R.A.; Bozzoni, I.; Mariottini, P.; Ceci, R.; Cervelli, M.
Emerging role for linear and circular spermine oxidase RNAs in skeletal muscle physiopathology
Int. J. Mol. Sci.
21
8227
2020
Mus musculus (Q99K82), Mus musculus
Sun, L.; Yang, J.; Qin, Y.; Wang, Y.; Wu, H.; Zhou, Y.; Cao, C.
Discovery and antitumor evaluation of novel inhibitors of spermine oxidase
J. Enzyme Inhib. Med. Chem.
34
1140-1151
2019
Homo sapiens (Q9NWM0)
Di Paolo, M.L.; Cervelli, M.; Mariottini, P.; Leonetti, A.; Polticelli, F.; Rosini, M.; Milelli, A.; Basagni, F.; Venerando, R.; Agostinelli, E.; Minarini, A.
Exploring the activity of polyamine analogues on polyamine and spermine oxidase methoctramine, a potent and selective inhibitor of polyamine oxidase
J. Enzyme Inhib. Med. Chem.
34
740-752
2019
Mus musculus (Q99K82)
Sagor, G.H.M.; Inoue, M.; Kusano, T.; Berberich, T.
Expression profile of seven polyamine oxidase genes in rice (Oryza sativa) in response to abiotic stresses, phytohormones and polyamines
Physiol. Mol. Biol. Plants
27
1353-1359
2021
Oryza sativa Japonica Group (A0A0P0XM10), Oryza sativa Japonica Group (Q0J290), Oryza sativa Japonica Group (Q0J954), Oryza sativa Japonica Group (Q7XR46)
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