1.5.3.16: spermine oxidase
This is an abbreviated version!
For detailed information about spermine oxidase, go to the full flat file.
Word Map on EC 1.5.3.16
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1.5.3.16
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polyamine
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putrescine
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acetylpolyamine
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back-conversion
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n1-acetylspermine
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n1-acetylpolyamine
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3-aminopropanal
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acrolein
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benspm
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medicine
- 1.5.3.16
- polyamine
- putrescine
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acetylpolyamine
-
back-conversion
- n1-acetylspermine
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n1-acetylpolyamine
- 3-aminopropanal
- acrolein
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benspm
- medicine
Reaction
Synonyms
AtPAO1, AtPAO4, AtPAO5, EC 1.5.3.11, Fms1 protein, GhPAO, hSMO, MmSMO, mSMO, mSMOalpha, mSMOmu, PAO, PAO1, PAO4, PAO5, PAO6, PAO7, PAOh1, PAOh1/SMO, SelPAO5, SMO, SMO(PAOh1), SMO/PAOh1, SMO5, SMOX, spermine oxidase, Spm oxidase, thermospermine oxidase
ECTree
1.5.3.16 spermine oxidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.5.3.16 - spermine oxidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
enzyme is involved in a polyamine back-conversion pathway
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
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the enzyme contributes to resistance of the plant against Verticillium dahliae through the mediation of spermine and camalexin signalling
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
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-
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
SMO may contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-aminopropanal
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
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the enzyme specifically oxidizes spermine
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
the enzyme is a regulator of macrophage host response to Helicobacter pylori. It enhances antimicrobial nitric oxide generation by depletion of spermine
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
the enzyme is involved in polyamine catabolism. Highly inducible enzyme that catalyzes the oxidative cleavage of spermine to form spermidine, 3-aminopropanal, and hydrogen peroxide
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
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the enzyme specifically oxidizes spermine
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
the enzyme is a regulator of macrophage host response to Helicobacter pylori. It enhances antimicrobial nitric oxide generation by depletion of spermine
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
the enzyme is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. The Total-Smox line is a genetic model useful to deepen the knowledge on the role of spermine oxidase in muscle atrophy and muscular pathological conditions like dystrophy
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?
spermine + O2 + H2O
spermidine + 3-aminopropanal + H2O2
the enzyme is involved in the catabolism of polyamines
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?
additional information
?
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no oxidation activity with spermidine
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?
additional information
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AtPAO4 deficiency induces alterations in the expression of genes related to the drought stress response and flavonoid biosynthesis
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?
additional information
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peroxisomal polyamine oxidase AtPAO4 is involved in the catabolism of polyamines in leaves, overview
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?
additional information
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PAOh1 is upregulated in response to polyamine analogue exposure. N1,N11-bis(ethyl)norspermine results in 5fold induction of PAO mRNA and a more than 3-fold induction of PAO activity
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?
additional information
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the major level of control of SMO(PAOh1) expression in response to polyamine analogues exposure is at the level of mRNA
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?
additional information
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TNF-alpha exposure leads to the induction of SMO/PAOh1, which produces sufficient H2O2 to result in potentially mutagenic DNA damage and presents a molecular mechanism by which general inflammation can contribute directly to the development of cancer
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?
additional information
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in mammalian cells, polyamine catabolism seems to be mediated by the activity of two enzymes, PAO and SMO
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?
additional information
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in mammalian cells, polyamine catabolism seems to be mediated by the activity of two enzymes, PAO and SMO
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?
additional information
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spermine oxidase activity is a direct oxidative stress inducer of DNA damage, thus rendering cells more sensitive to radiation and apoptosis
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additional information
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spermine oxidase activity is a direct oxidative stress inducer of DNA damage, thus rendering cells more sensitive to radiation and apoptosis
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additional information
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spermine oxidase overactivity can deliver sublethal chronic DNA damage and repair without affecting transcriptional and enzymatic levels of the PA key regulatory enzymes ornithine decarboxylase and spermidine/spermine N1-acetyltransferase
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?
