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1.5.3.13: N1-acetylpolyamine oxidase

This is an abbreviated version!
For detailed information about N1-acetylpolyamine oxidase, go to the full flat file.

Word Map on EC 1.5.3.13

Reaction

N1-acetylspermidine
+
O2
+
H2O
=
putrescine
+
3-acetamidopropanal
+
H2O2

Synonyms

APAO, AtPAO5, Bjpao2, EC 1.5.3.11, HPAO, hPAO-1, More, MPAO, N1-acetyl polyamine oxidase, N1-acetylpolyamine oxidase, PAO, PAO5, PAOh1, PAOX, polyamine oxidase, SelPAO5

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.13 N1-acetylpolyamine oxidase

Reference

Reference on EC 1.5.3.13 - N1-acetylpolyamine oxidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vujcic, S.; Liang, P.; Diegelman, P.; Kramer, D.L.; Porter, C.W.
Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion
Biochem. J.
370
19-28
2003
Homo sapiens (Q6QHF9), Homo sapiens
Manually annotated by BRENDA team
Royo, M.; Fitzpatrick, P.F.
Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate
Biochemistry
44
7079-7084
2005
Mus musculus (Q8C0L6), Mus musculus
Manually annotated by BRENDA team
Wang, Y.; Hacker, A.; Murray-Stewart, T.; Frydman, B.; Valasinas, A.; Fraser, A.V.; Woster, P.M.; Casero Jr, R.A.
Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity
Cancer Chemother. Pharmacol.
56
83-90
2005
Homo sapiens (Q6QHF9), Homo sapiens
Manually annotated by BRENDA team
Bianchi, M.; Polticelli, F.; Ascenzi, P.; Botta, M.; Federico, R.; Mariottini, P.; Cona, A.
Inhibition of polyamine and spermine oxidases by polyamine analogues
FEBS J.
273
1115-1123
2006
Mus musculus (Q8C0L6), Mus musculus
Manually annotated by BRENDA team
Jaervinen, A.; Keinaenen, T.A.; Grigorenko, N.A.; Khomutov, A.R.; Uimari, A.; Vepsaelaeinen, J.; Naervaenen, A.; Alhonen, L.; Jaenne, J.
Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase
J. Biol. Chem.
281
4589-4595
2006
Homo sapiens
Manually annotated by BRENDA team
Henderson Pozzi, M.; Gawandi, V.; Fitzpatrick, P.F.
pH dependence of a mammalian polyamine oxidase: insights into substrate specificity and the role of lysine 315
Biochemistry
48
1508-1516
2009
Mus musculus, Mus musculus (Q8C0L6)
Manually annotated by BRENDA team
Wu, T.; Yankovskaya, V.; McIntire, W.S.
Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase
J. Biol. Chem.
278
20514-20525
2003
Mus musculus (Q8C0L6), Mus musculus
Manually annotated by BRENDA team
Järvinen, A.; Grigorenko, N.; Khomutov, A.R.; Hyvönen, M.T.; Uimari, A.; Vepsäläinen, J.; Sinervirta, R.; Keinänen, T.A.; Vujcic, S.; Alhonen, L.; Porter, C.W.; Jänne, J.
Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines.
J. Biol. Chem.
280
6595-6601
2005
Homo sapiens
Manually annotated by BRENDA team
Basu, H.S.; Thompson, T.A.; Church, D.R.; Clower, C.C.; Mehraein-Ghomi, F.; Amlong, C.A.; Martin, C.T.; Woster, P.M.; Lindstrom, M.J.; Wilding, G.
A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model
Cancer Res.
69
7689-7695
2009
Homo sapiens
Manually annotated by BRENDA team
Takao, K.; Sugita, Y.; Shirahata, A.
Assay of N1-acetylpolyamine oxidase activity with N1,N11-didansylnorspermine as the substrate by ion-pair reversed phase high performance liquid chromatography
Biol. Pharm. Bull.
33
1089-1094
2010
Cricetulus griseus, Rattus norvegicus
Manually annotated by BRENDA team
Han, Y.; Ren, Y.S.; Cao, C.Y.; Ren, D.M.; Zhou, Y.Q.; Wang, Y.L.
Highly expressed N1-acetylpolyamine oxidase detoxifies polyamine analogue N1-cyclopropylmethyl-N11-ethylnorspermine in human lung cancer cell line A549
Chin. Med. Sci.
122
1394-1399
2009
Homo sapiens
Manually annotated by BRENDA team
Häkkinen, M.; Hyönen, M.; Auriola, S.; Casero Jr., R.; Vepsäläinen, J.; Khomutov, A.; Alhonen, L.; Keinänen, T.
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases
Amino Acids
38
369-381
2010
Homo sapiens
Manually annotated by BRENDA team
Moriya, S.; Iwasaki, K.; Samejima, K.; Takao, K.; Kohda, K.; Hiramatsu, K.; Kawakita, M.
A mass spectrometric method to determine activities of enzymes involved in polyamine catabolism
Anal. Chim. Acta
748
45-52
2012
Homo sapiens
Manually annotated by BRENDA team
Moriya, S.S.; Miura, T.; Takao, K.; Sugita, Y.; Samejima, K.; Hiramatsu, K.; Kawakita, M.
Development of irreversible inactivators of spermine oxidase and N1-acetylpolyamine oxidase
Biol. Pharm. Bull.
37
475-480
2014
Homo sapiens
Manually annotated by BRENDA team
Sagor, G.H.; Inoue, M.; Kim, D.W.; Kojima, S.; Niitsu, M.; Berberich, T.; Kusano, T.
The polyamine oxidase from lycophyte Selaginella lepidophylla (SelPAO5), unlike that of angiosperms, back-converts thermospermine to norspermidine
FEBS Lett.
589
3071-3078
2015
Selaginella lepidophylla (A0A0M3VGH5), Selaginella lepidophylla
Manually annotated by BRENDA team
Tavladoraki, P.; Cona, A.; Angelini, R.
Copper-containing amine oxidases and FAD-dependent polyamine oxidases are key players in plant tissue differentiation and organ development
Front. Plant Sci.
7
824
2016
Selaginella lepidophylla (A0A0M3VGH5), Arabidopsis thaliana (Q9SU79)
Manually annotated by BRENDA team
Wang, H.; Liu, B.; Li, H.; Zhang, S.
Identification and biochemical characterization of polyamine oxidases in amphioxus Implications for emergence of vertebrate-specific spermine and acetylpolyamine oxidases
Gene
575
429-437
2016
Branchiostoma japonicum (A0A0N7IZL9)
Manually annotated by BRENDA team
Kim, D.W.; Watanabe, K.; Murayama, C.; Izawa, S.; Niitsu, M.; Michael, A.J.; Berberich, T.; Kusano, T.
Polyamine oxidase 5 regulates Arabidopsis growth through Thermospermine oxidase activity
Plant Physiol.
165
1575-1590
2014
Arabidopsis thaliana (Q9SU79)
Manually annotated by BRENDA team
Sjogren, T.; Wassvik, C.; Snijder, A.; Aagaard, A.; Kumanomidou, T.; Barlind, L.; Kaminski, T.; Kashima, A.; Yokota, T.; Fjellstrom, O.
The structure of murine N1-acetylspermine oxidase reveals molecular details of vertebrate polyamine catabolism
Biochemistry
56
458-467
2017
Mus musculus (Q8C0L6)
Manually annotated by BRENDA team
Keinaenen, T.A.; Grigorenko, N.; Khomutov, A.R.; Huang, Q.; Uimari, A.; Alhonen, L.; Hyvoenen, M.T.; Vepsaelaeinen, J.
Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators
Biosci. Rep.
38
BSR20180527
2018
Homo sapiens (Q6QHF9), Homo sapiens
Manually annotated by BRENDA team
Di Paolo, M.L.; Cervelli, M.; Mariottini, P.; Leonetti, A.; Polticelli, F.; Rosini, M.; Milelli, A.; Basagni, F.; Venerando, R.; Agostinelli, E.; Minarini, A.
Exploring the activity of polyamine analogues on polyamine and spermine oxidase methoctramine, a potent and selective inhibitor of polyamine oxidase
J. Enzyme Inhib. Med. Chem.
34
740-752
2019
Mus musculus (Q8C0L6)
Manually annotated by BRENDA team
Khomutov, M.; Hyvonen, M.; Simonian, A.; Weisell, J.; Vepsalainen, J.; Alhonen, L.; Kochetkov, S.; Keinanen, T.; Khomutov, A.
Acetylated derivatives of C-methylated analogues of spermidine synthesis and interaction with N1-acetylpolyamine oxidase
Mendeleev Commun.
28
479-481
2018
Homo sapiens (Q6QHF9)
-
Manually annotated by BRENDA team