1.5.1.8: saccharopine dehydrogenase (NADP+, L-lysine-forming)
This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NADP+, L-lysine-forming), go to the full flat file.
Word Map on EC 1.5.1.8
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1.5.1.8
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alpha-aminoadipate
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hyperlysinemia
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pipecolic
-
dihydrodipicolinate
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aminoadipic
-
homocitrate
-
medicine
- 1.5.1.8
- alpha-aminoadipate
- hyperlysinemia
-
pipecolic
- dihydrodipicolinate
-
aminoadipic
- homocitrate
- medicine
Reaction
Synonyms
AasS, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming), L-lysine-alpha-ketoglutarate reductase, LKR, LKR/SDH, LOR, LOR-SDH, lysine 2-oxoglutarate reductase, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine alpha-ketoglutarate reductase, lysine ketoglutarate reductase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-2-oxoglutarate reductase, lysine-alpha-ketoglutarate reductase, lysine-ketoglutarate reductase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, lysine-ketoglutaric reductase, lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[glutaryl-2]-L-lysine forming), nllkr/sdh, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (NADP, lysine-forming), saccharopine dehydrogenase (nicotinamide adenine dinucleotide phosphate, lysine-forming)
ECTree
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.5.1.8 - saccharopine dehydrogenase (NADP+, L-lysine-forming)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-lysine + 2-oxoglutarate + NADH + H+
-
-
-
r
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
uni-directional activity plays an important role in regulating the catabolic function of alpha-aminoadipidic acid pathway in plants and stems from structure rather than its linkage to saccharopine dehydrogenase EC 1.5.1.9
-
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first enzyme in lysine catabolism
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
major catabolic pathway of lysine in mammalian livers
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
L-lysine catabolism is reversibly osmo-regulated at the level of LKR/SDH bifunctional enzyme
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first and possibly a rate-limiting step in lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first and major regulatory step in lysine catabolism, lysine may auto-regulate its own catabolism in vivo, plant seeds: active enzyme is a phosphoprotein, its activity is modulated by opposing actions of protein kinases and phosphatases
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
important role in the degradation of lysine
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is stimulated in vivo upon treatment with protein phosphatase inhibitor
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
increase in free lysine concentration in cells decrease enzyme activity through repression of lys1 gene, precursor alpha-aminoadipic-delta-semialdehyde modulates a transcriptional factor that controls transcription of lys1 gene
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
plays essential role in lysine biosynthesis, LKR and SDH are separate polypeptides
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine anabolic function is regulated by complex transcriptional and post-transcriptional controls
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
activity of native enzyme is inhibited after modulation, enzyme undergoes a conformational alteration to expose the catalytic domain for substrate binding, Ca2+ may be the most important physiological modulator of enzyme activity, it possibly activates through the derepression of an inhibitory domain in vivo
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first step in lysine breakdown in the endosperm during seed development
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
the enzyme is involved in lysine degradation
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
