1.5.1.7: saccharopine dehydrogenase (NAD+, L-lysine-forming) This is an abbreviated version! For detailed information about saccharopine dehydrogenase (NAD+, L-lysine-forming), go to the full flat file .
Reaction
N6-(L-1,3-dicarboxypropyl)-L-lysine +
NAD+ +
H2O =
L-lysine +
2-oxoglutarate +
NADH +
H+
Synonyms dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming), epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), Fvsdh, LYS1, Lys1p, Lysine--2-oxoglutarate reductase, lysine-2-oxoglutarate reductase, N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine: NAD oxidoreductase, N6-(glutaryl-2)-L-lysine: NAD+ oxidoreductase, N6-(glutaryl-2)-l-lysine:NAD oxidoreductase, N6-(glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming), N6-(glutaryl-2)-L-lysine:NAD-oxidoreductase (L-lysine-forming), N6-(glutaryl-2)-L-lysine:nicotinamide adenine dinucleotide (NAD+) oxidoreductase (L-lysine-forming), NAD+-linked saccharopine dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (L-lysine-forming), SDH
ECTree
Reaction
Reaction on EC 1.5.1.7 - saccharopine dehydrogenase (NAD+, L-lysine-forming)
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
mechanism
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
model of proton shuttle mechanism. Concerted proton and hydride transfer, proton transfer exists in at least two sequential transition states
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
ordered addition of NAD followed by saccharopine in the physiologic reaction direction. In the opposite direction, NADH adds to the enzyme first, while there is no preference for the order of binding of alpha-ketoglutarate and lysine
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
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