1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP+)

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For detailed information about methylenetetrahydrofolate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.5.1.5

1.5.1.5

one-carbon

cyclohydrolase

thymidylate

trifunctional

methenyltetrahydrofolate

5,10-methenyltetrahydrofolate

10-formyltetrahydrofolate

mthfd1l

folate-dependent

formyltetrahydrofolate

folate-mediated

c1-tetrahydrofolate

3.5.4.9

transcobalamin

10-formyl-thf

6.3.4.3

remethylation

5,10-methenyl-thf

1-carbon

dehydrogenase-cyclohydrolase

megaloblastic

medicine

Reaction

Synonyms

5, 10-methylenetetrahydrofolate dehydrogenase, 5,10-CH2-THF dehydrogenase, 5,10-mehtylene tetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, bmMTHFD, CH2-THF dehydrogenase, Cpe FolD, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH1, FolD, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, MIS1, mitochondrial methylenetetrahydrofolate dehydrogenase, MTHFD, MTHFD1, MTHFD1 protein, MTHFD2, MTHFD2 protein, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase, NADP-dependent 5,10-methylene-THF dehydrogenase

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)

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Results	in table
6	Activating Compound
45268	AA Sequence
3	Application
1	CAS Registry Number
21	Cloned(Commentary)
64	Cofactor
5	Crystallization (Commentary)
236	Disease/ Diagnostics
1	Expression
20	General Information
10	General Stability
14	IC50 Value
56	Inhibitors
20	kcat/KM [mM/s]
9	Ki Value [mM]
82	KM Value [mM]
22	Localization
14	Metals/Ions
30	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
421	Organism
16	Pathway
72	PDB ID
13	pH Optimum
3	pH Range
16	Protein Variants
36	Purification (Commentary)
1	Reaction
6	Reaction Type
66	Reference
57	Source Tissue
34	Specific Activity [micromol/min/mg]
13	Storage Stability
91	Substrates and Products (Substrate)
19	Subunits
73	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
28	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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100000

2 entries

101000

Homo sapiens

trifunctional enzyme: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase, transcription-translation of a cDNA clone

392315

104500

Saccharomyces cerevisiae

2 * 104500, SDS-PAGE

392314

108000

Ovis aries

2 * 108000, 1 * 218000 intramolecular cross-linked with dimethylsuberimidate, SDS-PAGE

392324

150000

Sus scrofa

methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration

1505, 209727, 392319

201000

2 entries

218000

Ovis aries

2 * 108000, 1 * 218000 intramolecular cross-linked with dimethylsuberimidate, SDS-PAGE

22000

SDS-PAGE

226000

methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration

1505

228000

Ovis aries

methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration

392324

30000

Moorella thermoacetica

2 * 30000, SDS-PAGE

392309

30600

Thermoplasma acidophilum

SDS-PAGE

31000

31900

2 * 31900, calculated from amino acid sequence

720406

33000

Sus scrofa

x * 33000, fragment has methylenetetrahydrofolate dehadrogenase and methenyltetrahydrofolate cyclohydrase activity, proteolysis, SDS-PAGE

392317

34000

Homo sapiens

MTHFD2 evolves from a trifunctional dehydrogenase-cyclohydrolase-synthetase precursor with the loss of synthetase function

36700

38500

? * 38500, probably not a heterodimer, SDS-PAGE

209737

50000

Moorella thermoacetica

equilibrium ultracentrifugation

392311

55000

Moorella thermoacetica

methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase combined, equilibrium ultracentrifugation

392309

57000

Pisum sativum

1 * 57000, bifunctional protein: methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase, SDS-PAGE

1518

58000

Pisum sativum

methylenetetrahydrofolate dehydrogenase-methyltetrahydrofolate cyclohydrolase protein, gel filtration

209737

60000

Pisum sativum

methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase protein, gel filtration

65000

gel filtration

70000

Clostridium cylindrosporum

sucrose density gradient centrifugation

392310