1.5.1.49: 1-pyrroline-2-carboxylate reductase [NAD(P)H]
This is an abbreviated version!
For detailed information about 1-pyrroline-2-carboxylate reductase [NAD(P)H], go to the full flat file.
Reaction
Synonyms
LhpH
ECTree
1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]Advanced search results
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Substrates Products on EC 1.5.1.49 - 1-pyrroline-2-carboxylate reductase [NAD(P)H]
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
preference of the reaction equilibrium to the direction toward NADH dependent reduction. In the oxidization of L-proline the ratio of NADP+ to NAD+ in kcat/Km value is about 150:1
-
-
r
L-proline + NADP+
DELTA1-pyrroline-2-carboxylate + NADPH + H+
preference of the reaction equilibrium to the direction toward NADH dependent reduction. In the oxidization of L-proline the ratio of NADP+ to NAD+ in kcat/Km value is about 150:1
-
-
r
additional information
?
-
no significant activity with DELTA1-piperideine-2-carboxylate or L-pipecolate. The kcat/Km values for DELTA1-piperideine-2-carboxylate and L-pipecolate in the presence of NADP+(H) are 111fold and 223fold lower than those for DELTA1-pyrroline-2-carboxylate and L-proline, mainly caused by 90fold and 51fold lower kcat values, respectively
-
-
?
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
the enzyme is part of the trans-3-hydroxy-L-proline pathway
-
-
?
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
preference of the reaction equilibrium to the direction toward NADPH dependent reduction. The kcat/Km value for DELTA1-pyrroline-2-carboxylate in the presence of NADH is 5.6fold lower than that in the presence of NADPH, mainly caused by the 12fold lower kcat value
-
-
?
DELTA1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
the enzyme is part of the trans-3-hydroxy-L-proline pathway
-
-
?
DELTA1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
preference of the reaction equilibrium to the direction toward NADPH dependent reduction. The preferred cofactor is NADPH, lower activity with NADH. The kcat/Km value for DELTA1-pyrroline-2-carboxylate in the presence of NADH is 5.6fold lower than that in the presence of NADPH, mainly caused by the 12fold lower kcat value
-
-
?
