1.5.1.34: 6,7-dihydropteridine reductase
This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.
Word Map on EC 1.5.1.34
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1.5.1.34
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tetrahydrobiopterin
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hydroxylase
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bh4
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hyperphenylalaninemia
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neurotransmitter
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phenylketonuria
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biopterin
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pterins
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dopamine
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quinonoid
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sepiapterin
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1.6.99.7
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cyclohydrolase
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6-pyruvoyl-tetrahydropterin
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5-hydroxytryptophan
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tetrahydropterin
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dihydrobiopterin
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l-dopa
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ptp
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folinic
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nadh-specific
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homovanillic
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pterin-4a-carbinolamine
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guthrie
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6-pyruvoyl
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dihydropterins
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gtpch
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medicine
- 1.5.1.34
- tetrahydrobiopterin
- hydroxylase
- bh4
- hyperphenylalaninemia
-
neurotransmitter
- phenylketonuria
- biopterin
- pterins
- dopamine
-
quinonoid
- sepiapterin
-
1.6.99.7
-
cyclohydrolase
- 6-pyruvoyl-tetrahydropterin
- 5-hydroxytryptophan
- tetrahydropterin
- dihydrobiopterin
- l-dopa
- ptp
-
folinic
-
nadh-specific
-
homovanillic
-
pterin-4a-carbinolamine
-
guthrie
-
6-pyruvoyl
- dihydropterins
- gtpch
- medicine
Reaction
Synonyms
7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)
ECTree
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General Information
General Information on EC 1.5.1.34 - 6,7-dihydropteridine reductase
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malfunction
metabolism
physiological function
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the brain stem of intrauterine growth-restricted offspring show significant increase of L-tryptophan, 5-hydroxytryptamine, tryptophan-5-hydroxylase and also dihydropteridine activity in the brain stem in comparison to controls. Intrauterine growth restriction produces an increase of serotonin biosynthesis in the brain stem. This is accompanied by an increase in dihydropteridine activity that appears to be a compensatory mechanism to maintain sufficient tetrahydrobiopterin for the donation of electrons during the accelerated synthesis of brain serotonin in intrauterine growth-restricted rats
malfunction
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enzyme inhibition results in a significant increase in transforming growth factor-beta1 expression
malfunction
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tetrahydrobiopterin deficiency is associated with numerous metabolic syndromes and neuropsychological disorders
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enzyme catalyzes the last step of tetrahydrobiopterin recycling
metabolism
inhibition of de novo biosynthesis of tetrahydrobiopterin by preincubating the cells for 24 h with the GTP cyclohydrolase inhibitor DAHP (10 mM) diminishes L-citrulline formation. Addition of dihydrobiopterin fully restores L-citrulline formation. In addition to its effect on arginine-to-citrulline conversion, pretreatment of the cells with DAHP reduces A23187-induced cGMP accumulation. Addition of tetrahydrobiopterin or dihydrobiopterin not only antagonizes the inhibitory effect of DAHP but also increases cGMP accumulation. (6R)-5,6,7,8-Tetrahydro-L-biopterin availability regulates nitric oxide and superoxide formation by endothelial nitric oxide synthase (eNOS). At low tetrahydrobiopterin or low tetrahydrobiopterin to 7,8-dihydrobiopterin ratios the enzyme becomes uncoupled and generates superoxide at the expense of NO
metabolism
inhibition of de novo biosynthesis of tetrahydrobiopterin by preincubating the cells for 24 h with the GTP cyclohydrolase inhibitor dihydroxyacetone phosphate (10 mM) diminishes L-citrulline formation. Addition of dihydrobiopterin fully restores L-citrulline formation. In addition to its effect on arginine-to-citrulline conversion, pretreatment of the cells with dihydroxyacetone phosphate reduces A23187-induced cGMP accumulation. Addition of tetrahydrobiopterin or dihydrobiopterin not only antagonizes the inhibitory effect of dihydroxyacetone phosphate but also increases cGMP accumulation. (6R)-5,6,7,8-Tetrahydro-L-biopterin availability regulates nitric oxide and superoxide formation by endothelial nitric oxide synthase (eNOS). At low tetrahydrobiopterin or low tetrahydrobiopterin to 7,8-dihydrobiopterin ratios the enzyme becomes uncoupled and generates superoxide at the expense of NO
metabolism
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the enzyme is involved in the De novo pathway and regeneration pathway of tetrahydrobiopterin biosynthesis
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enzyme in the regeneration pathway of tetrahydrobiopterin, expression is reduced in hypertensive rats compared to normotensive rats, tetrahydrobiopterin levels are attenuated in hypertensive rat aortic smooth muscle, tetrahydrobiopterin inhibits a serotonin-mediated vascular contraction increase
physiological function
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the enzyme is an important factor mediating diabetic nephropathy through its regulation of transforming growth factor-beta1/Smad3 signaling and NADPH oxidase
physiological function
the enzyme catalyzes (6R)-5,6,7,8-tetrahydro-L-biopterin recycling in endothelial cytosols
physiological function
the enzyme catalyzes (6R)-5,6,7,8-tetrahydro-L-biopterin recycling in endothelial cytosols with high affinity for dihydrobiopterin
physiological function
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the enzyme is important in the regeneration pathway of tetrahydrobiopterin, BH4. Tetrahydrobiopterin (BH4) is an essential cofactor of aromatic amino acid hydroxylases and nitric oxide synthase so that BH4 plays a key role in many biological processes