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1.5.1.33: pteridine reductase

This is an abbreviated version!
For detailed information about pteridine reductase, go to the full flat file.

Word Map on EC 1.5.1.33

Reaction

5,6,7,8-tetrahydrobiopterin
+ 2 NADP+ =
biopterin
+ 2 NADPH + 2 H+

Synonyms

Atu1130, EC 1.1.1.253, H region methotrexate resistance protein, LaPTR1, LbPTR1, LdPTR1, LmPTR1, LpPTR1, More, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, PruA, pteridine reductase, pteridine reductase 1, pteridine reductase I, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), Tb-PR, TbPTR1, tcptr1

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.33 pteridine reductase

pH Range

pH Range on EC 1.5.1.33 - pteridine reductase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 8
the enzyme has a pH profile somewhat broader than that of other pteridine reductases and exhibits about 20% of maximal activity at pH 8.0, inactive at pH 10.0, maximal activity at pH 6.0
4 - 9
4.5 - 7
-
pH 4.5: about 50% of maximal activity, pH 7.0: about 30% of maximal activity with biopterin
4.7 - 7
-
significant decline of activity at pH 7 and 4.7