Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.5.1.3: dihydrofolate reductase

This is an abbreviated version!
For detailed information about dihydrofolate reductase, go to the full flat file.

Word Map on EC 1.5.1.3

Reaction

5,6,7,8-tetrahydrofolate
+
NADP+
=
7,8-dihydrofolate
 +
NADPH
 +
H+

Synonyms

5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, 7,8-dihydrofolate reductase, At2g16370, At4g34570, bifunctional dihydrofolate reductase-thymidylate synthase, bifunctional TS-DHFR, BmDHFR, dehydrogenase, tetrahydrofolate, DFR-TS, DFR1, DfrA, DfrB, DHFR, DHFR type IIIC, DHFR-TS, DHFR-TS1, DHFR-TS2, DHFR2, DHFRL1, DHFRLS, dihydrofolate reductase, dihydrofolate reductase-like, dihydrofolate reductase-thymidylate synthase, dihydrofolate reductase:thymidylate synthase, dihydrofolic acid reductase, dihydrofolic reductase, EC 1.5.1.4, ecDHFR, folA, folA3, folic acid reductase, folic reductase, FolM, hDHFR, hDHFR-1, hDHFR-2, HjDHFR, hvDHFR1, hvDHFR2, LAU_0427, LBRM_06_0830, mDHFR, mjDHFR, More, myDHFR, NADPH-dihydrofolate reductase, pcDHFR, PKNH_0509600, ppDHFR, pteridine reductase, pteridine reductase:dihydrofolate reductase, PTR2, R-plasmid-encoded dihydrofolate reductase, R67 DHFR, R67 dihydrofolate reductase, reductase, dihydrofolate, S3DHFR, Smdhfr, Smp 175230, spDHFR, svDHFR, tcptr1, tetrahydrofolate dehydrogenase, THY-1, THY-2, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase-dihydrofolate reductase, Trimethoprim resistance protein, TS-DHFR, WUBG_00817

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.3 dihydrofolate reductase

Source Tissue

Source Tissue on EC 1.5.1.3 - dihydrofolate reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
enzyme activity is highly increased in the cancer cell line
Manually annotated by BRENDA team
evaluation of cytotoxicity of compounds 2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine and 2,4-diamino-5-isopropyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine against 17 different tumor cell lines. GI values of compound 2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine are below 100 nM
Manually annotated by BRENDA team
-
cervical tissue biopsies, including cervical intraepithelial neoplasia 1, cervical intraepithelial neoplasia 2, cervical intraepithelial neoplasia 3
Manually annotated by BRENDA team
-
cultured 3T6 mouse embryo fibroblasts
Manually annotated by BRENDA team
-
knock-down of dihydrofolate reductase or heart and neural crest derivatives expressed transcript HAND2 in fertilized eggs causes cardiac malformation
Manually annotated by BRENDA team
DHFR-TS1 is alternatively spliced in mature leaves
Manually annotated by BRENDA team
-
tumor cell line
Manually annotated by BRENDA team
-
source of Pneumocystis carnii
Manually annotated by BRENDA team
-
DHFR is overexpressed in melanoma cells
Manually annotated by BRENDA team
highest level of enzyme present in ova and brain
Manually annotated by BRENDA team
-
DHFR is overexpressed in SkMel-28 melanoma cells
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
-
derived from rat lung
Manually annotated by BRENDA team