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BRENDA support

1.5.1.3: dihydrofolate reductase

This is an abbreviated version!
For detailed information about dihydrofolate reductase, go to the full flat file.

Word Map on EC 1.5.1.3

Reaction

5,6,7,8-tetrahydrofolate
+
NADP+
=
7,8-dihydrofolate
+
NADPH
+
H+

Synonyms

5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, 7,8-dihydrofolate reductase, At2g16370, At4g34570, bifunctional dihydrofolate reductase-thymidylate synthase, bifunctional TS-DHFR, BmDHFR, dehydrogenase, tetrahydrofolate, DFR-TS, DFR1, DfrA, DfrB, DHFR, DHFR type IIIC, DHFR-TS, DHFR-TS1, DHFR-TS2, DHFR2, DHFRL1, DHFRLS, dihydrofolate reductase, dihydrofolate reductase-like, dihydrofolate reductase-thymidylate synthase, dihydrofolate reductase:thymidylate synthase, dihydrofolic acid reductase, dihydrofolic reductase, EC 1.5.1.4, ecDHFR, folA, folA3, folic acid reductase, folic reductase, FolM, hDHFR, hDHFR-1, hDHFR-2, HjDHFR, hvDHFR1, hvDHFR2, LAU_0427, LBRM_06_0830, mDHFR, mjDHFR, More, myDHFR, NADPH-dihydrofolate reductase, pcDHFR, PKNH_0509600, ppDHFR, pteridine reductase, pteridine reductase:dihydrofolate reductase, PTR2, R-plasmid-encoded dihydrofolate reductase, R67 DHFR, R67 dihydrofolate reductase, reductase, dihydrofolate, S3DHFR, Smdhfr, Smp 175230, spDHFR, svDHFR, tcptr1, tetrahydrofolate dehydrogenase, THY-1, THY-2, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase-dihydrofolate reductase, Trimethoprim resistance protein, TS-DHFR, WUBG_00817

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.3 dihydrofolate reductase

Organism

Organism on EC 1.5.1.3 - dihydrofolate reductase

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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene dhfr-ts
UniProt
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
overview
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-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
trimethoprim-susceptible strain PC 174 and trimethoprim-resistant strain PC 178
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Enterococcus faecalis R / ATCC 8043
-
-
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Manually annotated by BRENDA team
var. durans
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-
Manually annotated by BRENDA team
Escherichia coli B / ATCC 11303
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Manually annotated by BRENDA team
Escherichia coli MB 1428 / B / ATCC 11303
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
Halalkalibacterium halodurans
Halalkalibacterium halodurans C-125
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-
Manually annotated by BRENDA team
i.e. Helicoverpa virescens, tobacco budworm
-
-
Manually annotated by BRENDA team
human virus produced in cultured lymphoma derived B-cells
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-
Manually annotated by BRENDA team
R-plasmid encoded, trimethoprim-resistant
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-
Manually annotated by BRENDA team
bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
UniProt
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
2 forms, not genetically determined isozymes
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Pigeon
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-
Manually annotated by BRENDA team
bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
UniProt
Manually annotated by BRENDA team
bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
UniProt
Manually annotated by BRENDA team
bifunctional dihydrofolate reductase/thymidylate synthase
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-
Manually annotated by BRENDA team
protozoa
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UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
trimethoprim-resistant enzyme
-
-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
methicillin-sensitive and -resistant strains
-
-
Manually annotated by BRENDA team
Tequatrovirus T4
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Manually annotated by BRENDA team
overview
-
-
Manually annotated by BRENDA team
sequence lacks a crucial, conserved 13 amino acid loop
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team