1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]

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For detailed information about methylenetetrahydrofolate reductase [NAD(P)H], go to the full flat file.

Reaction

Synonyms

10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NADP+ oxidoreductase, AtMTHFR-1, EC 1.1.1.171, EC 1.1.1.68, EC 1.1.99.15, EC 1.7.99.5, HsMTHFR, MET13, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolic acid reductase, MetVF-type methylenetetrahydrofolate reductase, More, MTHFR, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase, NADH:CH2-H4folate oxidoreductase, NapAB, reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate), reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide), respiratory nitrate reductase, type II-MTHFR

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

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9	Activating Compound
46906	AA Sequence
26	Application
2	CAS Registry Number
19	Cloned(Commentary)
150	Cofactor
9	Crystallization (Commentary)
177	Disease/ Diagnostics
18	General Information
8	General Stability
9	IC50 Value
68	Inhibitors
4	kcat/KM [mM/s]
14	Ki Value [mM]
70	KM Value [mM]
13	Localization
12	Metals/Ions
31	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
291	Organism
2	Oxidation Stability
6	Pathway
37	PDB ID
16	pH Optimum
4	pH Range
1	pH Stability
4	Posttranslational Modification
175	Protein Variants
26	Purification (Commentary)
9	Reaction
3	Reaction Type
261	Reference
1	Renatured (Commentary)
125	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
280	Substrates and Products (Substrate)
30	Subunits
407	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
25	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

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SYSTEMATIC NAME

IUBMB Comments

5-methyltetrahydrofolate:NAD(P)+ oxidoreductase

A flavoprotein (FAD). The enzyme catalyses the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. This enzyme, characterized from Protozoan parasites of the genus Leishmania, is unique among similar characterized eukaryotic enzymes in that it lacks the C-terminal allosteric regulatory domain (allowing it to catalyse a reversible reaction) and uses NADH and NADPH with equal efficiency under physiological conditions. cf. EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).