1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase [NAD(P)H], go to the full flat file.

Word Map on EC 1.5.1.20

1.5.1.20

nitrite

homocysteine

medicine

paracoccus

assimilatory

denitrification

chlorate

narghi

resde

napc

molybdoenzyme

pantotrophus

ammonification

nutrition

analysis

Reaction

Synonyms

10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NADP+ oxidoreductase, AtMTHFR-1, EC 1.1.1.171, EC 1.1.1.68, EC 1.1.99.15, EC 1.7.99.5, HsMTHFR, MET13, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolic acid reductase, MetVF-type methylenetetrahydrofolate reductase, More, MTHFR, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase, NADH:CH2-H4folate oxidoreductase, NapAB, reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate), reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide), respiratory nitrate reductase, type II-MTHFR

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

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Results	in table
9	Activating Compound
46906	AA Sequence
26	Application
2	CAS Registry Number
19	Cloned(Commentary)
150	Cofactor
9	Crystallization (Commentary)
177	Disease/ Diagnostics
18	General Information
8	General Stability
9	IC50 Value
68	Inhibitors
4	kcat/KM [mM/s]
14	Ki Value [mM]
70	KM Value [mM]
13	Localization
12	Metals/Ions
31	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
291	Organism
2	Oxidation Stability
6	Pathway
37	PDB ID
16	pH Optimum
4	pH Range
1	pH Stability
4	Posttranslational Modification
175	Protein Variants
26	Purification (Commentary)
9	Reaction
3	Reaction Type
261	Reference
1	Renatured (Commentary)
125	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
280	Substrates and Products (Substrate)
30	Subunits
407	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
25	Turnover Number [1/s]

KM Value

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KM Value on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

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0.003

(+)-5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate

Rattus norvegicus

437717

0.18

(6R)-5,10-methylenetetrahydrofolate

Thermus thermophilus

Q5SLG6

at pH 7.0 and 50°C

726277

0.0005 - 0.287

5,10-methylenetetrahydrofolate

20 entries

0.019 - 0.16

5-methyltetrahydrofolate

7 entries

0.0019

5-methyltetrahydropteroylhexaglutamate

Sus scrofa

392158

0.033

5-methyltetrahydropteroylmonoglutamate

Sus scrofa

392158

11.1

benzyl viologen

Clostridium formicaceticum

437713, 437714

0.0004 - 0.187

methylenetetrahydrofolate

6 entries

0.0027 - 0.585

NADH

15 entries

0.0073 - 0.049

NADPH

11 entries

additional information

4 entries