1.5.1.2: pyrroline-5-carboxylate reductase
This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.
Word Map on EC 1.5.1.2
Reaction
Synonyms
1-pyrroline-5-carboxylate reductase, aldimine reductase, DELTA1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase 2, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, PROC, proline oxidase, Pycr1, PYCR2, Pyr5C reductase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate, TcCLB.509207.90
ECTree
1.5.1.2 pyrroline-5-carboxylate reductaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 1.5.1.2 - pyrroline-5-carboxylate reductase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
([[(3,5-dibromophenyl)methyl]amino]methylene)bis(phosphonic acid)
competitive inhibition against both 1-pyrroline 5-carboxylate and NADPH. Growth of myelogenous erythroleukemic K562 and epithelial breast cancer MDA-MB-231 cell lines is progressively impaired by concentrations ranging from 1-100 microM
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([[(3,5-dichlorophenyl)methyl]amino]methylene)bis(phosphonic acid)
competitive inhibition against both 1-pyrroline 5-carboxylate and NADPH
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([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)
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71.2% inhibition at 0.2 mM
N-ethylmaleimide
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90% inhibition at 0.02 mM, inhibition can be prevented by NADH
N-formyl-L-proline
competitive. Compound phenocopies the PYCR1 knockdown in MCF10A H-RASV12 breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth
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p-hydroxymercuribenzoate
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90% inhibition at 0.008 mM, inhibition can be prevented by addition of excess dithiothreitol
stearoyl-CoA
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competitive inhibitor of P5CR NAD(P)H-dependent thioproline dehydrogenase activity
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
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52% inhibition at 0.2 mM
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
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63.9% inhibition at 0.2 mM
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
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92.5% inhibition at 0.2 mM
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)
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98.4% inhibition at 0.2 mM
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
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71.2% inhibition at 0.2 mM
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)
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94.5% inhibition at 0.2 mM
L-proline
at 0-500 microM, the value of KMapp increases whereas Vlim remains fairly unchanged, which is consistent with competitive inhibition
L-proline
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L-proline inhibits the inverse reaction at a concentration of 10-20 mM
L-proline
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L-proline inhibits the inverse reaction at a concentration of 10-20 mM
NADH
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slight inhibition with 25% reduction of the catalytic rate at 200 mM
p-chloromercuribenzoate
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complete inhibition at 0.125 mM, can be prevented by addition of dithiothreitol
proline
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39% inhibition of the NADH dependent activity and 17% of the NADPH dependent activity at 10 mM
proline
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competitive inhibitor of P5CR NAD(P)H-dependent thioproline dehydrogenase activity
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
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95.4% inhibition at 0.2 mM
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
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96.2% inhibition at 0.2 mM
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
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91.1% inhibition at 0.2 mM
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
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70.5% inhibition at 0.2 mM
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
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61.5% inhibition at 0.2 mM
additional information
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enzyme is not inhibited by the proline-analog L-thiazolidine-4-carboxylic acid
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additional information
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enzyme is not inhibited by the proline-analog L-thiazolidine-4-carboxylic acid
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