1.5.1.18: ephedrine dehydrogenase

This is an abbreviated version!
For detailed information about ephedrine dehydrogenase, go to the full flat file.

Reaction

Synonyms

EDH

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.18 ephedrine dehydrogenase

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Results	in table
1	AA Sequence
2	Application
1	CAS Registry Number
1	Cloned(Commentary)
5	Cofactor
4	General Information
1	General Stability
9	Inhibitors
2	kcat/KM [mM/s]
7	Ki Value [mM]
12	KM Value [mM]
9	Natural Substrates/ Products (Substrates)
3	Organism
2	Pathway
4	pH Optimum
1	pH Range
5	pH Stability
2	Purification (Commentary)
1	Reaction
4	Reaction Type
3	Reference
1	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
38	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
10	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.5.1.18 - ephedrine dehydrogenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(-)-ephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH

2 entries

(-)-ephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+

Arthrobacter sp. TS-15

A0A545BBR2

-

755862

-

-

?

(R,R)-(-)-pseudoephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+

2 entries

(R,S)-(-)-ephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+

Arthrobacter sp. TS-15

A0A545BBR2

-

752351

-

-

r

1-phenylpropan-1,2-dione + NAD+

phenylacetylcarbinol + NADH + H+

2 entries

additional information

?

-

Arthrobacter sp. TS-15

A0A545BBR2

ephedrine dehydrogenase (EDH) exhibits strict selectivity for the oxidation of the diastereomers (R,S)-(-)-ephedrine and (R,R)-(-)-pseudoephedrine. Conversion of all ephedrine isomers required the addition of NAD+ as an oxidant. Without a surplus oxidant or in the presence of NADP+, cell lysates do not significantly convert ephedrine

755862

-

-

-

(-)-ephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH

Arthrobacter globiformis

-

first step in the catabolism of (-)-ephedrine

392100

-

392100

?

(-)-ephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH

Arthrobacter globiformis

-

plays role in the metabolism of quite a number of different aromatic and aliphatic amino alcohols

392100

-

392100

?

(R,R)-(-)-pseudoephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+

Arthrobacter sp. TS-15

A0A545BBR2

-

755862

-

-

?

(R,R)-(-)-pseudoephedrine + NAD+

(R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+

Arthrobacter sp. TS-15

A0A545BBR2

-

752351

-

-

r

1-phenylpropan-1,2-dione + NAD+

phenylacetylcarbinol + NADH + H+

Arthrobacter sp. TS-15

A0A545BBR2

-

755862

-

-

?

1-phenylpropan-1,2-dione + NAD+

phenylacetylcarbinol + NADH + H+

Arthrobacter sp. TS-15

A0A545BBR2

EDH overcomes the stability of the conjugated molecule PPD by reducing it to alpha-hydroxyketone (R)- and (S)-PAC, respectively. Phenylacetylcarbinol (PAC) cannot be oxidized by these dehydrogenases and possibly undergoes a cleavage reaction to yield benzaldehyde and acetaldehyde

755862

-

-

?