1.5.1.10: saccharopine dehydrogenase (NADP+, L-glutamate-forming)
This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NADP+, L-glutamate-forming), go to the full flat file.
Word Map on EC 1.5.1.10
-
1.5.1.10
-
alpha-aminoadipate
-
auxotrophs
-
magnaporthe
-
grisea
-
homocitrate
-
pipecolic
-
swainsonine
-
homoisocitrate
-
piperideine-6-carboxylic
-
chrysogenum
-
unlinked
-
rossmann
-
penicillium
-
ph-rate
-
endophytic
-
embedding
-
6-dehydrogenase
-
substrate-assisted
-
seven-stranded
-
diaminopimelate
-
oxytropis
-
acid-base
-
leaky
-
all-helical
-
anisotropic
-
l-pipecolate
-
dl-alpha-aminoadipate
-
gene-enzyme
- 1.5.1.10
- alpha-aminoadipate
-
auxotrophs
-
magnaporthe
- grisea
- homocitrate
-
pipecolic
- swainsonine
- homoisocitrate
-
piperideine-6-carboxylic
- chrysogenum
-
unlinked
-
rossmann
-
penicillium
-
ph-rate
-
endophytic
-
embedding
-
6-dehydrogenase
-
substrate-assisted
-
seven-stranded
- diaminopimelate
- oxytropis
-
acid-base
-
leaky
-
all-helical
-
anisotropic
- l-pipecolate
- dl-alpha-aminoadipate
-
gene-enzyme
Reaction
Synonyms
aminoadipate semialdehyde-glutamate reductase, aminoadipic semialdehyde-glutamate reductase, aminoadipic semialdehyde-glutamic reductase, ASS, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming), epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming), LKR/SDH, lysine-ketoglutarate reductase/saccharopine dehydrogenase, nSpe-Sdh, saccharopine dehydrogenase, saccharopine dehydrogenase (L-glutamate forming), saccharopine reductase, SDH, spermidine synthase-saccharopine dehydrogenase, SR1
ECTree
Advanced search results
Reference
Reference on EC 1.5.1.10 - saccharopine dehydrogenase (NADP+, L-glutamate-forming)
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ye, Z.H.; Bhattacharjee, J.K.
Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe
J. Bacteriol.
170
5968-5970
1988
Schizosaccharomyces pombe
Naranjo, L.; Martin de Valmaseda, E.; Banuelos, O.; Lopez, P.; Riano, J.; Casqueiro, J.; Martin, J.F.
Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: characterization of the lys7 gene encoding saccharopine reductase
J. Bacteriol.
183
7165-7172
2001
Penicillium chrysogenum (Q96TW2), Penicillium chrysogenum
Mukhopadhyay, A.; Mungre, S.M.; Desmukh, D.R.
Comparison of lysine and tryptophan catabolizing enzymes in rat and bovine tissues
Experientia
46
874-876
1990
Bos taurus, Rattus norvegicus
Schmidt, H.; Bode, R.; Birnbaum, D.
Regulation of the lysine biosynthesis in Pichia guilliermondii
Antonie van Leeuwenhoek
56
337-347
1989
Meyerozyma guilliermondii
Broquist, H.P.
Aminoadipic semialdehyde-glutamate reductase
Methods Enzymol.
17B
121-124
1971
Saccharomyces cerevisiae
-
Jones, E.E.; Broquist, H.P.
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase
J. Biol. Chem.
241
3430-3434
1966
Saccharomyces cerevisiae
Storts, D.R.; Bhattacharjee, J.K.
Purification and properties of saccharopine dehydrogenase (glutamate forming) in the Saccharomyces cerevisiae lysine biosynthetic pathway
J. Bacteriol.
169
416-418
1987
Saccharomyces cerevisiae
Kinzel, J.J.; Bhattacharjee, J.K.
Role of pipecolic acid in the biosynthesis of lysine in Rhodotorula glutinis
J. Bacteriol.
138
410-417
1979
Rhodotorula glutinis
Johansson, E.; Steffens, J.J.; Emptage, M.; Lindqvist, Y.; Schneider, G.
Cloning, expression, purification and crystallization of saccharopine reductase from Magnaporthe grisea
Acta Crystallogr. Sect. D
56
662-664
2000
Pyricularia grisea
-
Naranjo, L.; Martin de Valmaseda, E.; Casqueiro, J.; Ullan, R.V.; Lamas-Maceiras, M.; Banuelos, O.; Martin, J.F.
Inactivation of the lys7 gene, encoding saccharopine reductase in Penicillium chrysogenum, leads to accumulation of the secondary metabolite precursors piperideine-6-carboxylic acid and pipecolic acid from alpha-aminoadipic acid
Appl. Environ. Microbiol.
70
1031-1039
2004
Penicillium chrysogenum
Kingsbury, J.M.; Yang, Z.; Ganous, T.M.; Cox, G.M.; McCusker, J.H.
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans
Eukaryot. Cell
3
752-763
2004
Cryptococcus neoformans (Q6RXX2), Cryptococcus neoformans
Andi, B.; Cook, P.F.; West, A.H.
Crystal structure of the his-tagged saccharopine reductase from Saccharomyces cerevisiae at 1.7-A resolution
Cell Biochem. Biophys.
46
17-26
2006
Saccharomyces cerevisiae
Vashishtha, A.K.; West, A.H.; Cook, P.F.
Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae
Biochemistry
47
5417-5423
2008
Saccharomyces cerevisiae
Vashishtha, A.K.; West, A.H.; Cook, P.F.
Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae
Biochemistry
48
5899-5907
2009
Saccharomyces cerevisiae
Almasi, J.; Bushnell, E.; Gauld, J.
A QM/MM-based computational investigation on the catalytic mechanism of saccharopine reductase
Molecules
16
8569-8589
2011
Pyricularia oryzae (Q9P4R4)
Vashishtha, A.K.; West, A.H.; Cook, P.F.
Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis
Arch. Biochem. Biophys.
584
98-106
2015
Saccharomyces cerevisiae (P38999), Saccharomyces cerevisiae
Arruda, P.; Barreto, P.
Lysine catabolism through the saccharopine pathway enzymes and intermediates involved in plant responses to abiotic and biotic stress
Front. Plant Sci.
11
587
2020
Oryza sativa (A0A0K0K9B1), Zea mays (A0A3L6FCN0), Brassica napus (Q9FVF4), Arabidopsis thaliana (Q9SMZ4), Homo sapiens (Q9UDR5)
Xi, Z.; Yang, K.; Sheng, J.; Zhang, X.; Guo, J.; Meng, D.
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene with a possible role in postharvest development of the button mushroom (Agaricus bisporus)
J. Hortic. Sci. Biotechnol.
95
712-721
2020
Agaricus bisporus (D7GL19), Agaricus bisporus Sylvan A15 (D7GL19)
-
html completed