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(4R)-DELTA1-pyrroline-4-hydroxy-2-carboxylate + NADPH + H+
(4R)-4-hydroxy-L-proline + NADP+
-
-
-
r
1-piperideine-2-carboxylate + NAD(P)H + H+
L-pipecolate + NAD(P)+
1-pyrroline-(4R)-hydroxy-2-carboxylate + NADPH + H+
(4R)-hydroxy-L-proline + NADP+
-
-
-
r
1-pyrroline-2-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
?
cis-3-hydroxy-L-proline + NADP+
? + NADPH + H+
low activity
-
-
r
cis-4-hydroxy-L-proline + NADP+
? + NADPH + H+
low activity
-
-
r
DELTA1-piperideine 2-carboxylate + NADH + H+
L-pipecolate + NAD+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
DELTA1-piperidine-2-carboxylate + NADH + H+
L-pipecolate + NAD+
DELTA1-piperidine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
DELTA1-pyrroline-(4R)-hydroxy-2-carboxylate + NADPH + H+
(4R)-hydroxy-L-proline + NADP+
-
-
-
r
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
DELTA2-thiazoline-2-carboxylate + NADPH + H+
? + NADP+
-
-
-
?
L-pipecolate + NAD(P)+
1-piperideine-2-carboxylate + NAD(P)H + H+
-
-
-
r
L-pipecolate + NAD+
DELTA1-piperidine-2-carboxylate + NADH + H+
L-pipecolate + NADP+
DELTA1-piperidine-2-carboxylate + NADPH + H+
L-pipecolic acid + NAD(P)+
DELTA1-piperidine-2-carboxylate + NAD(P)H
-
at 26% of the rate with L-proline
-
-
r
L-proline + NAD(P)+
1-pyrroline-2-carboxylate + NAD(P)H + H+
-
-
-
r
L-proline + NAD(P)+
DELTA1-pyrroline-2-carboxylate + NAD(P)H + H+
-
-
-
-
r
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NADP+
DELTA1-pyrroline-2-carboxylate + NADPH + H+
trans-4-hydroxy-L-proline + NADP+
? + NADPH + H+
low activity
-
-
r
additional information
?
-
1-piperideine-2-carboxylate + NAD(P)H + H+
L-pipecolate + NAD(P)+
-
-
-
r
1-piperideine-2-carboxylate + NAD(P)H + H+
L-pipecolate + NAD(P)+
-
-
-
-
r
1-piperideine-2-carboxylate + NAD(P)H + H+
L-pipecolate + NAD(P)+
-
-
-
-
r
1-pyrroline-2-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
r
1-pyrroline-2-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
r
1-pyrroline-2-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
-
-
-
-
r
1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
?
1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
-
r
1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
-
r
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
?
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
Cercocebus sp.
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
?
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
-
r
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NAD(P)H
L-pipecolic acid + NAD(P)+
-
-
-
ir
DELTA1-piperidine-2-carboxylate + NADH + H+
L-pipecolate + NAD+
-
-
-
r
DELTA1-piperidine-2-carboxylate + NADH + H+
L-pipecolate + NAD+
-
-
-
r
DELTA1-piperidine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
r
DELTA1-piperidine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
-
-
-
r
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
Cercocebus sp.
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
?
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
at 55% of the rate with DELTA1-piperidine-2-carboxylate
-
-
r
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NAD(P)H
L-proline + NAD(P)+
-
-
-
ir
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
r
DELTA1-pyrroline-2-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
r
DELTA1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
r
DELTA1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
-
-
-
r
L-pipecolate + NAD+
DELTA1-piperidine-2-carboxylate + NADH + H+
-
-
-
r
L-pipecolate + NAD+
DELTA1-piperidine-2-carboxylate + NADH + H+
-
-
-
r
L-pipecolate + NADP+
DELTA1-piperidine-2-carboxylate + NADPH + H+
-
-
-
r
L-pipecolate + NADP+
DELTA1-piperidine-2-carboxylate + NADPH + H+
-
-
-
r
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
-
-
-
r
L-proline + NAD+
DELTA1-pyrroline-2-carboxylate + NADH + H+
-
-
-
r
L-proline + NADP+
DELTA1-pyrroline-2-carboxylate + NADPH + H+
-
-
-
r
L-proline + NADP+
DELTA1-pyrroline-2-carboxylate + NADPH + H+
-
-
-
r
additional information
?
-
trans-3-hydroxy-L-proline is converted to proline by the purified LhpH and LhpI proteins, i.e. trans-3-hydroxy-L-proline dehydratase and DELTA1-pyrroline-2-carboxylate reductase, at pH 7.0. LhpI has dual metabolic functions as a reductase for DELTA1-pyrroline-2-carboxylate and DELTA1-piperidine-2-carboxylate
-
-
?
additional information
?
-
-
trans-3-hydroxy-L-proline is converted to proline by the purified LhpH and LhpI proteins, i.e. trans-3-hydroxy-L-proline dehydratase and DELTA1-pyrroline-2-carboxylate reductase, at pH 7.0. LhpI has dual metabolic functions as a reductase for DELTA1-pyrroline-2-carboxylate and DELTA1-piperidine-2-carboxylate
-
-
?
additional information
?
-
no activity with trans-4-hydroxy-D-proline, D-proline, trans-3-hydroxy-L-proline, cis-4-hydroxy-D-proline, and cis-3-hydroxy-D-proline, poor activity with trans-4-hydroxy-L-proline
-
-
?
additional information
?
-
-
no activity with trans-4-hydroxy-D-proline, D-proline, trans-3-hydroxy-L-proline, cis-4-hydroxy-D-proline, and cis-3-hydroxy-D-proline, poor activity with trans-4-hydroxy-L-proline
-
-
?
additional information
?
-
reciprocal relationship between thyroid hormone binding and DELTA1-piperideine-2-carboxylate (P2C) binding to ketimine reductase
-
-
-
additional information
?
-
-
reciprocal relationship between thyroid hormone binding and DELTA1-piperideine-2-carboxylate (P2C) binding to ketimine reductase
-
-
-
additional information
?
-
purified recombinant human CRYM possesses substantial KR activity. Ketimine reductase is a typical imine reductase. Substrate specificity of recombinant human ketimine reductase (KR) toward DELTA1-piperideine-2-carboxylate (P2CR) and various noncyclized imine intermediates, overview. N-methyl-L-alanine is produced when human KR is incubated in the presence of methylamine, NADPH and pyruvate. Human KR catalyzes the reductive alkylamination of phenylpyruvate and glyoxylate in the presence of methylamine. Substrate docking
-
-
-
additional information
?
-
-
purified recombinant human CRYM possesses substantial KR activity. Ketimine reductase is a typical imine reductase. Substrate specificity of recombinant human ketimine reductase (KR) toward DELTA1-piperideine-2-carboxylate (P2CR) and various noncyclized imine intermediates, overview. N-methyl-L-alanine is produced when human KR is incubated in the presence of methylamine, NADPH and pyruvate. Human KR catalyzes the reductive alkylamination of phenylpyruvate and glyoxylate in the presence of methylamine. Substrate docking
-
-
-
additional information
?
-
-
involved in the catabolism of D-lysine and D-proline
-
-
?
additional information
?
-
-
reverse reactions oxidizing L-proline or L-pipecolic acid are catalyzed at much lower rates. Very poor substrates: trans-4-hydroxy-L-proline, L-thioproline
-
-
?
additional information
?
-
-
the enzyme from kidney shows no activity with DELTA1-pyrroline-5-carboxylate and DELTA1-piperideine-6-carboxylate
-
-
?