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1.4.3.4: monoamine oxidase

This is an abbreviated version!
For detailed information about monoamine oxidase, go to the full flat file.

Word Map on EC 1.4.3.4

Reaction

RCH2NHR'
+
H2O
 +
O2
=
RCHO
 +
R'NH2
 +
H2O2

Synonyms

adrenaline oxidase, amine-oxygen oxidoreductase, C-MAO, EC 1.4.3.9, epinephrine oxidase, MAO, MAO A, MAO B, MAO type B, MAO-A, MAO-B, MAO-N, MAO-N-D5, MAOA, MAOB, monoamine oxidase, monoamine oxidase A, monoamine oxidase B, monoamine oxidase N, monoamine oxidase type B, monoamine oxidase-A, monoamine oxidase-B, monoamine oxidaseA, monoamine oxidases A, monoamine oxidases B, monoamine-oxidase-A, monoamine: O2-oxidoreductase, deaminated, monoamine: O2-oxidoreductase, deaminating, monoamine: O2-oxidoreductase: deaminating, monoamine:O2 oxidoreductase (deaminating), monoamine:O2 oxidoreductase, deaminating, monoamine:O2-oxidoreductase deaminating, monoaminoxidase B, More, semicarbazide-sensitive amine oxidase, serotonin deaminase, SSAO, tyraminase, tyramine oxidase, zMAO

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.4 monoamine oxidase

Specific Activity

Specific Activity on EC 1.4.3.4 - monoamine oxidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00004
substrate histamine, at high substrate concentration
0.00009
substrate beta-phenylethylamine, at low substrate concentration
0.00011
substrate tyramine, at low substrate concentration
0.00015
-
crude extract, at pH 7.0 and 37°C
0.00018
substrate tyramine, at low substrate concentration
0.00019
substrate benzylamine, at low substrate concentration
0.00021
substrate beta-phenylethylamine, at low substrate concentration
0.0003
substrate benzylamine, at low substrate concentration
0.00036
substrate 1-methylhistamine, at high substrate concentration
0.00054
0.00092
substrate beta-phenylethylamine, at high substrate concentration
0.00095
substrate 1-methylhistamine, at high substrate concentration
0.00125
substrate benzylamine, at high substrate concentration
0.00155
substrate tyramine, at high substrate concentration
0.00163
substrate beta-phenylethylamine, at high substrate concentration
0.00175
substrate tyramine, at high substrate concentration
0.00316
substrate serotonin, at low substrate concentration
0.0032
-
crude extract, at pH 7.0 and 37°C
0.0046
substrate serotonin, at high substrate concentration
0.0125
-
-
0.014
substrate: (S)-1,2,3,4-tetrahydro-1-methylisoquinoline, mutant enzyme W230I/W430R, pH and temperature not specified in the publication
0.016
substrate: (S)-2-phenyl-pyrroline, mutant enzyme W230I/W430R, pH and temperature not specified in the publication
0.018
substrate: (S)-1,2,3,4-tetrahydro-1-methylisoquinoline, mutant enzyme W230I/T354S/W430R/M242R/Y365V, pH and temperature not specified in the publication
0.025
0.03
substrate: (S)-2-phenyl-pyrroline, mutant enzyme W230I/T354S/W430R/M242R/Y365V, pH and temperature not specified in the publication
0.04
substrate: (S)-2-phenyl-pyrroline, mutant enzyme W230R/W430C, pH and temperature not specified in the publication
0.043
substrate p-tyramine, monoamine oxidase A
0.09
substrate: (S)-2-phenyl-pyrroline, mutant enzyme T354S, pH and temperature not specified in the publication
0.108
substrate: (S)-1,2,3,4-tetrahydro-1-methylisoquinoline, mutant enzyme W230R/W430C, pH and temperature not specified in the publication
0.13
substrate: (S)-2-phenyl-pyrroline, wild-type enzyme, pH and temperature not specified in the publication
0.162
brain enzyme
0.22
substrate: (S)-1,2,3,4-tetrahydro-1-phenylisoquinoline, mutant enzyme W230I/W430R, pH and temperature not specified in the publication
0.243
brain enzyme
0.3
substrate: (S)-1,2,3,4-tetrahydro-1-phenylisoquinoline, mutant enzyme W230I/T354S/W430R, pH and temperature not specified in the publication
0.52
substrate: (S)-1,2,3,4-tetrahydro-1-phenylisoquinoline, mutant enzyme W230R/W430C/C214L, pH and temperature not specified in the publication
0.66
substrate: (S)-1,2,3,4-tetrahydro-1-methylisoquinoline, mutant enzyme W230R/W430C/C214L, pH and temperature not specified in the publication
0.67
substrate: (S)-1,2,3,4-tetrahydro-1-phenylisoquinoline, mutant enzyme W230I/T354S/W430R/M242R/Y365V, pH and temperature not specified in the publication
1.365
-
1544fold purified enzyme, at pH 7.0 and 37°C
additional information