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1.4.3.4: monoamine oxidase

This is an abbreviated version!
For detailed information about monoamine oxidase, go to the full flat file.

Word Map on EC 1.4.3.4

Reaction

RCH2NHR'
+
H2O
 +
O2
=
RCHO
 +
R'NH2
 +
H2O2

Synonyms

adrenaline oxidase, amine-oxygen oxidoreductase, C-MAO, EC 1.4.3.9, epinephrine oxidase, MAO, MAO A, MAO B, MAO type B, MAO-A, MAO-B, MAO-N, MAO-N-D5, MAOA, MAOB, monoamine oxidase, monoamine oxidase A, monoamine oxidase B, monoamine oxidase N, monoamine oxidase type B, monoamine oxidase-A, monoamine oxidase-B, monoamine oxidaseA, monoamine oxidases A, monoamine oxidases B, monoamine-oxidase-A, monoamine: O2-oxidoreductase, deaminated, monoamine: O2-oxidoreductase, deaminating, monoamine: O2-oxidoreductase: deaminating, monoamine:O2 oxidoreductase (deaminating), monoamine:O2 oxidoreductase, deaminating, monoamine:O2-oxidoreductase deaminating, monoaminoxidase B, More, semicarbazide-sensitive amine oxidase, serotonin deaminase, SSAO, tyraminase, tyramine oxidase, zMAO

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.4 monoamine oxidase

KM Value

KM Value on EC 1.4.3.4 - monoamine oxidase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.221
(1R,6S)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane
pH 7.0, 37°C
0.753
(1S,6R)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane
pH 7.0, 37°C
1.12 - 1.96
(S)-1,2,3,4-tetrahydro-1-methylisoquinoline
-
0.51 - 5.85
1,2,3,4-tetrahydronaphthalen-1-amine
-
10
1-(2 aminoethyl)pyrrolidine
-
at pH 7.4 and 37°C
0.034 - 0.103
1-(4-bromophenyl)methanamine
0.054 - 0.094
1-(4-chlorophenyl)methanamine
0.161 - 0.174
1-(4-fluorophenyl)methanamine
0.0555 - 0.08
1-(4-methoxyphenyl)methanamine
0.055 - 0.0678
1-(4-methylphenyl)methanamine
0.021 - 0.0635
1-methyl-3-(4-chlorophenyl)-3-pyrroline
0.0546 - 0.461
1-methyl-3-phenyl-3-pyrroline
0.0683
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine
0.033 - 0.797
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
0.115 - 0.194
1-[4-(trifluoromethyl)phenyl]methanamine
1.47 - 7.06
2,3-dihydro-1H-inden-1-amine
-
0.006
2-chlorobenzylamine
-
-
-
0.016 - 86
2-Phenylethylamine
60
3-(2,3-dihydro-1H-indole-1-yl)propan-1-amine
-
at pH 7.4 and 37°C
0.401 - 1.2
3-(4-(3-aminopropoxy)butoxy)-N-(thiophen-2-ylmethyl)propan-1-amine
4
3-azabicyclo[3,3,0]octane
-
at pH 7.4 and 37°C
0.04
3-chlorobenzylamine
-
-
0.17
3-methylbenzylamine
-
-
-
0.252
3-phenyl-3-pyrroline
pH 7.2, 30°C
2.8
3-Phenylpropylamine
-
-
0.414
4-benzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine
-
-
0.076
4-carboxybenzylamine
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.095
4-chlorobenzylamine
-
-
0.475
4-hydroxy-3-methoxy-2-phenylethylamine
-
-
0.0238
4-methoxy-2-phenylethylamine
-
-
0.185
4-phenylbutylamine
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.83 - 5.5
4-tyramine
0.57 - 3.5
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
0.187 - 0.19
5-hydroxytryptamine
0.0159
5-methoxytryptamine
-
-
5
alpha-methylbenzylamine
-
-
20
amylamine
-
-
0.0109 - 82
benzylamine
3.6
beta-phenylethylamine
-
-
18
cis-8-azabicyclo[4.3.0]nonane
-
at pH 7.4 and 37°C
0.088 - 4.71
dopamine
2
ethanolamine
-
at pH 7.0 and 37°C
0.13 - 20
ethylamine
4
heptamethyleneimine
-
at pH 7.4 and 37°C
3
hexamethyleneimine
-
at pH 7.4 and 37°C
3.6 - 5.61
histamine
0.0161 - 5.123
kynuramine
0.11
methylamine
-
at pH 7.0 and 37°C
0.11 - 2.36
n-butylamine
0.29 - 7.5
N-methylhistamine
0.5
n-Pentylamine
-
at pH 7.0 and 37°C
0.059
n-Propylamine
-
at pH 7.0 and 37°C
0.018 - 0.08
N1-(thiophen-2-ylmethyl)dodecane-1,12-diamine
0.012 - 0.044
N1-benzyl-N1-methyldodecane-1,12-diamine
0.043 - 0.05
N1-benzyldodecane-1,12-diamine
0.0093 - 0.33
O2
0.09 - 0.76
p-nitrobenzylamine
0.005 - 0.22
p-nitrophenylethylamine
0.05 - 2
p-trifluoromethyl-benzylamine
0.02031 - 0.19
p-tyramine
0.89
phenethylamine
11°C
0.0089 - 0.055
phenylbutylamine
0.0004 - 6.34
Phenylethylamine
0.069 - 4.7
serotonin
0.0185 - 5.1
tryptamine
0.018 - 6.14
tyramine
additional information
additional information
-