1.4.3.3: D-amino-acid oxidase
This is an abbreviated version!
For detailed information about D-amino-acid oxidase, go to the full flat file.
Word Map on EC 1.4.3.3
-
1.4.3.3
-
d-serine
-
schizophrenia
-
peroxisomal
-
flavin
-
n-methyl-d-aspartate
-
d-alanine
-
catalase
-
fad
-
nmda
-
deamination
-
benzoate
-
flavoenzyme
-
flavoproteins
-
racemase
-
variabilis
-
l-amino
-
neurotransmission
-
d-aspartate
-
gracilis
-
co-agonist
-
rhodotorula
-
cephalosporin
-
glutamatergic
-
urate
-
d-proline
-
d-ala
-
d-ser
-
imino
-
antipsychotic
-
hypofunction
-
d-methionine
-
isoalloxazine
-
acylase
-
fad-containing
-
toruloides
-
rhodosporidium
-
d-glutamate
-
fad-dependent
-
d-cysteine
-
kynurenic
-
sulfurtransferase
-
d-valine
-
synthesis
-
medicine
-
d-leucine
-
cerium
-
7-aminocephalosporanic
-
d-tryptophan
-
d-phenylalanine
-
neuregulin
-
3-mercaptopyruvate
-
sarcosine
-
industry
-
biotechnology
-
analysis
-
diagnostics
-
drug development
-
pharmacology
- 1.4.3.3
- d-serine
-
schizophrenia
- peroxisomal
- flavin
- n-methyl-d-aspartate
- d-alanine
- catalase
- fad
- nmda
-
deamination
- benzoate
-
flavoenzyme
- flavoproteins
- racemase
- variabilis
-
l-amino
-
neurotransmission
- d-aspartate
- gracilis
-
co-agonist
- rhodotorula
- cephalosporin
-
glutamatergic
- urate
- d-proline
- d-ala
- d-ser
-
imino
-
antipsychotic
-
hypofunction
- d-methionine
- isoalloxazine
- acylase
-
fad-containing
- toruloides
- rhodosporidium
- d-glutamate
-
fad-dependent
- d-cysteine
-
kynurenic
- sulfurtransferase
- d-valine
- synthesis
- medicine
- d-leucine
- cerium
-
7-aminocephalosporanic
- d-tryptophan
- d-phenylalanine
- neuregulin
- 3-mercaptopyruvate
- sarcosine
- industry
- biotechnology
- analysis
- diagnostics
- drug development
- pharmacology
Reaction
Synonyms
chDAO, D-AAO, D-amino acid oxidase, D-amino-acid-oxidase, D-aminoacid oxidase, DAAO, DAMOX, DAO, DAO1, DaoE, hDAAO, ophio-amino-acid oxidase, oxidase, D-amino acid, PEG-DAO, pkDAAO, RgDAAO, TvDAAO, TvDAO, LH99
ECTree
1.4.3.3 D-amino-acid oxidaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.4.3.3 - D-amino-acid oxidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
a D-amino acid + H2O + O2
a 2-oxo acid + NH3 + H2O2
-
D-amino-acid oxidase catalyzes the oxidative deamination of D-amino acids, stereoisomers of the naturally occurring L-amino acids
-
-
?
D-3,4-dihydroxyphenylalanine + H2O + O2
?
-
D-Dopa undergoes unidirectional chiral inversion and further suggest that D-Dopa is first oxidatively deaminated by DAAO to its alpha-keto acid and then transaminated by dopa transaminase to L-Dopa
-
-
?
D-amino acid + H2O + O2
a 2-oxo carboxylate + NH3 + H2O2
-
-
-
-
ir
D-Arg + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-citrulline + H2O + O2
2-oxo-5-ureidopentanoic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
enzyme works as a metabolizing agent of exogenous and endogenous free D-Ala that is abundant in aquatic invertebrates such as crustaceans and bivalve mollusks, which are potential food sources of the fish. After oral administration of D-Ala at 0.005 mM/g body weight per day to carp for 30 days, enzyme activity increases by about 8fold, 3fold, and 1.5fold in intestine, hepatopancreas, and kidney, respectively, whereas no increase is found in brain
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
the inducible enzyme plays an important physiological role in metabolizing exogenous D-Ala that is abundant in their prey invertebrates, crustaceans, and mollusks
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
-
-
-
?
D-alanine + H2O + O2
pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-alanine + H2O + O2
pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-amino acid + H2O + O2
2-oxocarboxylate + NH3 + H2O2
-
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-cysteine + H2O + O2
2-oxo-3-thiopropionic acid + NH3 + H2O2
-
-
-
-
?
D-ethionine + H2O + O2
4-ethylsulfanyl-2-oxobutyric acid + NH3 + H2O2
-
-
-
-
?
D-ethionine + H2O + O2
4-ethylsulfanyl-2-oxobutyric acid + NH3 + H2O2
-
-
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
D-serine, an endogenous agonist of the N-methyl-D-aspartate, NMDA, receptors, is effective in the treatment of schizophrenia. However, orally administered D-serine is metabolized substantially by D-amino acid oxidase diminishing its oral bioavailability
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
metabolizaation of the N-methyl D-aspartate receptor co-agonist
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
the apoprotein form of hDAAO binds the substrate D-serine, which increases FAD binding thus increasing the amount of active holoenzyme in solution
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
low catalytic efficiency and substrate affinity on the physiological substrate D-serine
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
physiological effects of D-serine, overview
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
physiological effects of D-serine, overview
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
astroglial enzyme plays an important role in metabolizing a neuromodulator, D-serine
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyric acid + NH3 + H2O2
-
-
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-tryptophan + H2O + O2
indole-3-pyruvic acid + NH3 + H2O2
-
DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid
-
-
?
D-tryptophan + H2O + O2
indole-3-pyruvic acid + NH3 + H2O2
DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
-
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
-
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
-
-
-
?
thiazolidine-2-carboxylic acid + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
additional information
?
-
-
DAAO is a catabolic flavoenzyme that catalyzes the oxidative deamination of D-amino acids to the corresponding a-keto acids, hydrogen peroxide, and ammonia. DAAO is strictly specific for D-isomers of amino acids
-
-
?
additional information
?
-
-
the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
-
-
?
additional information
?
-
DAAO interacts with its physiological partner pLG72, the interaction is not inhibited by benzoate and chlorpromazine
-
-
?
additional information
?
-
-
DAAO interacts with its physiological partner pLG72, the interaction is not inhibited by benzoate and chlorpromazine
-
-
?
additional information
?
-
-
the amount of the neutral D-amino acids are regulated, each D-amino acid is regulated in a different way
-
-
?
additional information
?
-
-
DAO catalyzes the oxidative degradation of most of the D-amino acids in mammals
-
-
?
additional information
?
-
-
D-amino acid oxidase is an enzyme catalyzing the strict stereospecificity the oxidative deamination of neutral and polar D-amino acids to alpha-keto acids, NH3 and hydrogen peroxide
-
-
?
additional information
?
-
-
the flavoenzyme catalyzes the oxidative deamination of neutral and basic D-amino acids to the corresponding 2-oxo acids and H2O2 with concomitant reduction of FAD
-
-
?
additional information
?
-
-
the enzyme interacts with the mammalian protein modulator pLG72
-
-
?
additional information
?
-
-
first enzyme involved in the catabolism of D-amino acids. The inducer D-Ala acts by increasing the rate of DAAO mRNA transcription. Ammonium sulfate appears to have a negative effect on DAAO mRNA translation and on the expression of DAAO activity. The best expression of DAAO activity is obtained by growing the cells for 12 h at 30°C in the presence of glucose and D-alanine using cell pre-cultured for 10 h on glucose and L-Ala
-
-
?
additional information
?
-
the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
-
-
?
additional information
?
-
-
the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the conversion of cephalosporin C
-
-
?
additional information
?
-
the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
-
-
?
