1.4.3.21: primary-amine oxidase

This is an abbreviated version!
For detailed information about primary-amine oxidase, go to the full flat file.

Reaction

Synonyms

AGAO, AMAO2, AMAO3, amine oxidase 1, amine oxidase, copper containing, AO1, AO2, AOC2, AOC3, BAO, benzylamine oxidase, bovine plasma amine oxidase, bovine serum amine oxidase, BPAO, BSAO, CAO, Copper amine oxidase, copper amine oxidase 1, copper amine oxidase 8, copper-containing amine oxidase, copper-containing AO, copper-containing monoamine oxidase, copper-dependent amine oxidase, copper/quinone containing amine oxidase, Cu/TPQ amine oxidase, CuAO, CuAO1, CuAO2, CuAO3, CuAO8, EC 1.4.3.6, ECAO, ELAO, GPAO, grass pea amine oxidase, Hansenula polymorpha amine oxidase, HPAO, hPAO-1, HPAO-2, lentil seedling amine oxidase, LSAO, MAO-N, More, OVAO, PAO, pea seedling amine oxidase, plasma amine oxidase, PrAO, primary amine oxidase, primary-amine:oxygen oxidoreductase, PSAO, quinone- and copper-containing amine oxidase, quinone-containing copper amine oxidase, quinone-dependent amine oxidase, quinoprotein copper-containing amine oxidase, RAO, sainfoin amine oxidase, semicarbazide-sensitive amine oxidase, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1, SSAO, SSAO/VAP-1, TPQ-containing CuAO, tynA, tyramine oxidase, copper-requiring, VAP-1, vascular adhesion protein 1, vascular adhesion protein-1

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.3 With oxygen as acceptor

                1.4.3.21 primary-amine oxidase

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Results	in table
4	Activating Compound
155	AA Sequence
4	Application
23	Cloned(Commentary)
38	Cofactor
17	Crystallization (Commentary)
1020	Disease/ Diagnostics
11	Expression
14	General Information
1	General Stability
110	IC50 Value
365	Inhibitors
60	kcat/KM [mM/s]
39	Ki Value [mM]
129	KM Value [mM]
22	Localization
67	Metals/Ions
27	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
135	Organism
14	Pathway
174	PDB ID
12	pH Optimum
4	pH Range
1	pH Stability
4	pI Value
7	Posttranslational Modification
35	Protein Variants
28	Purification (Commentary)
5	Reaction
126	Reference
101	Source Tissue
32	Specific Activity [micromol/min/mg]
342	Substrates and Products (Substrate)
38	Subunits
257	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
92	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2.9

2-aminoethylpyridine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

0.00021 - 76

2-Phenylethylamine

12 entries

1.9

3-aminomethylpyridine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

3.1

4-aminomethylpyridine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

17.3

4-fluorobenzylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

1.46

aminoacetone

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

4.33 - 12.7

amylamine

3 entries

0.066 - 198

benzylamine

8 entries

0.00612 - 20.77

beta-phenylethylamine

11 entries

4.3 - 15.3

Butylamine

3 entries

0.0619 - 1

cadaverine

2 entries

5.36

cyclohexanemethylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

1.11

cysteamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

0.54 - 1.9

dopamine

2 entries

3.3

ethanolamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

0.16 - 20

ethylamine

6 entries

0.46 - 13.2

histamine

4 entries

6.89

Isoamylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

7.4

Isobutylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

0.4 - 6.2

methylamine

6 entries

1.13 - 152

O2

8 entries

3.5

octopamine

Rhodococcus opacus

-

isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

1.12

phenethylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

20.9

Phenylethylamine

Rhodococcus opacus

-

isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

5.8 - 18.9

Propylamine

2 entries

1.9 - 160

putrescine

3 entries

0.0429 - 2.3

spermidine

2 entries

2.7

tryptamine

Lens culinaris

-

-

676364

1.6 - 35

tyramine

5 entries

1

vanillylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

0.00021

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, mutant enzyme D298A

672146

0.63

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, Ni-activated enzyme

671976

0.92

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, Co-activated enzyme

671976

1.3

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, Ni2+-substituted enzyme

655782

1.51

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, Co2+-substituted enzyme

655782

1.72

2-Phenylethylamine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO3, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

5.12

2-Phenylethylamine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

12.4

2-Phenylethylamine

Escherichia coli

P46883

wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 25°C

724280

44

2-Phenylethylamine

Arthrobacter globiformis

-

in 50mM HEPES buffer, pH 6.8, at 15°C

725314

75.7

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, native copper protein

655782

75.7

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, Cu-activated enzyme

671976

76

2-Phenylethylamine

Arthrobacter globiformis

P46881

pH 6.8, 30°C, wild-type enzyme

672146

4.33

amylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

5.9

amylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

12.7

amylamine

Rhodococcus opacus

-

isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

0.066

benzylamine

Ogataea angusta

P12807

in 100 mM potassium phosphate, pH 7.2, temperature not specified in the publication

724373

0.066

benzylamine

Ogataea angusta

P12807

isoform HPAO-1, at 25°C, in 100 mM potassium phosphate, pH 7.2

724283

0.24

benzylamine

Arthrobacter globiformis

-

in 50mM HEPES buffer, pH 6.8, at 15°C

725314

1.4

benzylamine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

3.42

benzylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

8.1

benzylamine

Ogataea angusta

P12807

isoform HPAO-2, at 25°C, in 100 mM potassium phosphate, pH 7.2

724283

12.1

benzylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

188 - 198

benzylamine

Sus scrofa

-

-

391914

0.00612

beta-phenylethylamine

Escherichia coli

-

pH 8.0, mutant enzyme D383E

654501

0.00937

beta-phenylethylamine

Escherichia coli

-

pH 7.0, mutant enzyme D383E

654501

0.01163

beta-phenylethylamine

Escherichia coli

-

pH 5.5, mutant enzyme D383E

654501

0.012

beta-phenylethylamine

Escherichia coli

-

pH 6.0, mutant enzyme D383E

654501

9.6

beta-phenylethylamine

Escherichia coli

-

pH 5.5, wild-type enzyme

654501

11.45

beta-phenylethylamine

Escherichia coli

-

pH 5.75, wild-type enzyme

654501

13.32

beta-phenylethylamine

Escherichia coli

-

pH 7.5, wild-type enzyme

654501

13.68

beta-phenylethylamine

Escherichia coli

-

pH 8.0, wild-type enzyme

654501

14.98

beta-phenylethylamine

Escherichia coli

-

pH 7.0, wild-type enzyme

654501

20.7

beta-phenylethylamine

Escherichia coli

-

pH 6.0, wild-type enzyme

654501

20.77

beta-phenylethylamine

Escherichia coli

-

pH 6.5, wild-type enzyme

654501

4.3

Butylamine

Rhodococcus opacus

-

isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

6.31

Butylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

15.3

Butylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

0.0619

cadaverine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

1

cadaverine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

0.54

dopamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

1.9

dopamine

Rhodococcus opacus

-

isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

0.16

ethylamine

Ogataea angusta

-

pH 7, 37°C, mutant enzyme Y305F

672133

6.12

ethylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

7.2

ethylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

7.5

ethylamine

Ogataea angusta

-

pH 7, 37°C, mutant enzyme Y305A

672133

20

ethylamine

Ogataea angusta

-

pH 7, 37°C, wild-type enzyme

672133

20

ethylamine

Ogataea angusta

P12807

in 100 mM potassium phosphate, pH 7.2, temperature not specified in the publication

724373

0.46

histamine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO3, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

1.8

histamine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

5.91

histamine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

13.2

histamine

Rhodococcus opacus

-

isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

0.4

methylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

2.08

methylamine

Ogataea angusta

-

Co2+ reconstituted enzyme

391960

2.12

methylamine

Ogataea angusta

-

native enzyme

391960

2.18

methylamine

Ogataea angusta

P12807

isoform HPAO-2, at 25°C, in 100 mM potassium phosphate, pH 7.2

724283

5.6

methylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

6.2

methylamine

Ogataea angusta

P12807

isoform HPAO-1, at 25°C, in 100 mM potassium phosphate, pH 7.2

724283

1.13

O2

Arthrobacter globiformis

P46881

pH 6.8, 30°C, Ni2+-substituted enzyme

655782

1.24

O2

Arthrobacter globiformis

P46881

pH 6.8, 30°C, Co2+-substituted enzyme

655782

2.1

O2

Ogataea angusta

-

Co-substituted enzyme

654616

7.1

O2

Pisum sativum

-

cobalt-substituted wild type enzyme, with putrescine as cosubstrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C

725549

7.8

O2

Ogataea angusta

-

wild-type enzyme

654616

99

O2

Pisum sativum

-

copper-reconstituted wild type enzyme, with putrescine as cosubstrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C

725549

110

O2

Arthrobacter globiformis

P46881

pH 6.8, 30°C, native copper protein

655782

152

O2

Pisum sativum

-

wild type enzyme, with putrescine as cosubstrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C

725549

5.8

Propylamine

Homo sapiens

Q16853

at pH 7.4, 37°C

726290

18.9

Propylamine

Rhodococcus opacus

-

isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

1.9

putrescine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

82

putrescine

Pisum sativum

-

copper-reconstituted wild type enzyme, in 100 mM potassium phosphate buffer, pH 7.2, 37°C

725549

160

putrescine

Pisum sativum

-

wild type enzyme, in 100 mM potassium phosphate buffer, pH 7.2, 37°C

725549

0.0429

spermidine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

2.3

spermidine

Huperzia serrata

I6NC69

in 50 mM Tris-HCl buffer, pH 8.0, at 25°C

724537

1.6

tyramine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO3, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

3.95

tyramine

Paenarthrobacter aurescens

A1R2C3, A1RDD3

isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C

726536

12.8

tyramine

Lens culinaris

-

-

676364

16.1

tyramine

Rhodococcus opacus

-

isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C

725733

35

tyramine

Arthrobacter globiformis

-

in 50mM HEPES buffer, pH 6.8, at 15°C

725314