1.4.3.21: primary-amine oxidase
This is an abbreviated version!
For detailed information about primary-amine oxidase, go to the full flat file.
Word Map on EC 1.4.3.21
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1.4.3.21
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endothelial
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diamine
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1.4.3.6
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ssaos
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deamination
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polyamines
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leukocyte
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putrescine
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lymphocyte
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spermine
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methylamine
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lysyl
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vessel
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arthrobacter
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extravasation
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phenylhydrazine
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2,4,5-trihydroxyphenylalanine
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globiformis
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elastin
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cadaverine
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klinman
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biogenic
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aminoguanidine
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half-reaction
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histaminase
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semiquinone
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pargyline
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acrolein
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pyrroloquinoline
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transmigration
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allylamine
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clorgyline
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beta-aminopropionitrile
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aminoacetone
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copper-binding
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self-processing
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quinoproteins
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2-phenylethylamine
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addressins
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deprenyl
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phenelzine
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medicine
- 1.4.3.21
- endothelial
- diamine
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1.4.3.6
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ssaos
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deamination
- polyamines
- leukocyte
- putrescine
- lymphocyte
- spermine
- methylamine
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lysyl
- vessel
- arthrobacter
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extravasation
- phenylhydrazine
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2,4,5-trihydroxyphenylalanine
- globiformis
- elastin
- cadaverine
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klinman
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biogenic
- aminoguanidine
-
half-reaction
- histaminase
- semiquinone
- pargyline
- acrolein
-
pyrroloquinoline
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transmigration
- allylamine
- clorgyline
- beta-aminopropionitrile
- aminoacetone
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copper-binding
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self-processing
-
quinoproteins
- 2-phenylethylamine
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addressins
- deprenyl
- phenelzine
- medicine
Reaction
Synonyms
AGAO, AMAO2, AMAO3, amine oxidase 1, amine oxidase, copper containing, AO1, AO2, AOC2, AOC3, BAO, benzylamine oxidase, bovine plasma amine oxidase, bovine serum amine oxidase, BPAO, BSAO, CAO, Copper amine oxidase, copper amine oxidase 1, copper amine oxidase 8, copper-containing amine oxidase, copper-containing AO, copper-containing monoamine oxidase, copper-dependent amine oxidase, copper/quinone containing amine oxidase, Cu/TPQ amine oxidase, CuAO, CuAO1, CuAO2, CuAO3, CuAO8, EC 1.4.3.6, ECAO, ELAO, GPAO, grass pea amine oxidase, Hansenula polymorpha amine oxidase, HPAO, hPAO-1, HPAO-2, lentil seedling amine oxidase, LSAO, MAO-N, More, OVAO, PAO, pea seedling amine oxidase, plasma amine oxidase, PrAO, primary amine oxidase, primary-amine:oxygen oxidoreductase, PSAO, quinone- and copper-containing amine oxidase, quinone-containing copper amine oxidase, quinone-dependent amine oxidase, quinoprotein copper-containing amine oxidase, RAO, sainfoin amine oxidase, semicarbazide-sensitive amine oxidase, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1, SSAO, SSAO/VAP-1, TPQ-containing CuAO, tynA, tyramine oxidase, copper-requiring, VAP-1, vascular adhesion protein 1, vascular adhesion protein-1
ECTree
1.4.3.21 primary-amine oxidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.4.3.21 - primary-amine oxidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
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?
alpha-casein + H2O + O2
?
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the enzyme oxidizes the lysine residues in alpha-casein protein
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?
tropoelastin + H2O + O2
?
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the enzyme oxidizes the lysine residues in tropoelastin protein
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-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
low activity
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-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
Schizosaccharomyces pombe FY435 / ATCC 87284
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-
-
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?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
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-
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?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
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-
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?
additional information
?
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MAO-N is a flavoenzyme that catalyses the oxidative deamination of primary amines, substrate specificity, overview
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?
additional information
?
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Semicarbazide-sensitive amine oxidase acts as a vascular-adhesion protein, mediating the adhesion of lymphocytes to vascular endothelial cells under inflammatory conditions
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?
additional information
?
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physiologic role for SSAO in elastin maturation
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?
additional information
?
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SSAO may contribute to the vascular damage associated to Alzheimers disease
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?
additional information
?
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synergistic interaction between semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in diabetes. Semicarbazide-sensitive amine oxidase is involved in the following biological processes: vision, inflammatory response, biogenic amine metabolism, catecholamine metabolism, amine metabolism, cell adhesion
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?
additional information
?
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semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines
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?
additional information
?
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semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines
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?
additional information
?
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the catalytic center is deeply buried within the enzyme and is accessible only through a narrow channel with a diameter of about 4.5 A. This channel is gated by the side chain of L469 which, along with the copper-TPQ coordination, controls the catalytic activity of SSAO. While specific interactions with residues lining the surface of the accessing channel are important for substrate specificity, the flexibility of substrates also plays an important role, molecular dynamics and induced docking studies, detailed overview
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?
additional information
?
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VAP-1/SSAOs convert amines into aldehydes. SSAOs are distinct from the mammalian monoamine oxidases, MAOs, but their substrate specificities are partly overlapping
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?
additional information
?
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VAP-1/SSAOs convert amines into aldehydes. SSAOs are distinct from the mammalian monoamine oxidases, MAOs, but their substrate specificities are partly overlapping
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?
additional information
?
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T0901317 inhibits SSAO gene expression and its activity in atherogenic apoE-/- mice. The atheroprotective effect of LXR agonist T0901317 is related to the inhibition of SSAO gene expression and its activity
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?
additional information
?
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the catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding aldehyde with the concomitant reduction of the organic cofactor 2,4,5-trihydroxyphenylalanine quinone and an oxidative half-reaction in which reduced 2,4,5-trihydroxyphenylalanine quinone is re-oxidized with the reduction of molecular oxygen to hydrogen peroxide
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?
additional information
?
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the catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding aldehyde with the concomitant reduction of the organic cofactor 2,4,5-trihydroxyphenylalanine quinone and an oxidative half-reaction in which reduced 2,4,5-trihydroxyphenylalanine quinone is re-oxidized with the reduction of molecular oxygen to hydrogen peroxide
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?
