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1.4.3.2: L-amino-acid oxidase

This is an abbreviated version!
For detailed information about L-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.2

Reaction

an L-amino acid
+
H2O
 +
O2
=
a 2-oxo carboxylate
 +
NH3
 +
H2O2

Synonyms

AAD, ACTX-6, ACTX-8, Akbu-LAAO, APIT, apotxin, aromatic L-amino acid oxidase, Balt-LAAO-I, bordonein-L, Bpir-LAOO-1, CC-LPOX, DAA, Dolabellanin, escapin, head kidney and gill, IL4I1, Il4i1 protein, ink toxin 1, Interleukin Four Induced Gene 1 protein, L-AAO, L-AAO/MOG, L-AAO1, L-amino acid oxidase, L-amino acid: O2 oxidoreductase, L-amino acid:O2 oxidoreductase, L-amino acid:O2 oxidoreductase (deaminating), L-aminooxidase, L-Aox, L-phenylalanine oxidase, LAAO, LAAO-1, LAAO-I, LAAO-II, LAAO1, LAAO4, LAAOI, LAAOII, LAO, LAO1, M-LAO, ophio-amino-acid oxidase, Pm1, RoLAAO, sarA, Sebastes schlegeli antibacterial protein, Sebastes schlegelii antibacterial protein, SSAP, TJ-LAO, toxophallin, TSV-LAO

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.2 L-amino-acid oxidase

Activating Compound

Activating Compound on EC 1.4.3.2 - L-amino-acid oxidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-chloromercuribenzoate
about 5timer higher activity in the presence of 3 mM 4-chloromercuribenzoate
alpha,alpha'-dipyridyl
-
119% activity at 1 mM (pH 7.0)
CaCl2
-
2 mM, 50% activation
FAD
activates at 0.002 mM, inhibits at 0.004-0.008 mM
KCN
-
enhances the lysine oxidase activity (177% activity at 1 mM (pH 5.5))
N-ethylmaleimide
-
remarkably enhances the lysine oxidase activity (500% activity at 1 mM (pH 7.0))
p-chloromercuribenzoic acid
-
remarkably enhances the lysine oxidase activity
PMSF
-
exposure of the enzyme to phenylmethylsulfonyl fluoride results in the LAAO expressing anticoagulant activity, preventing contact activation generated thrombin from forming a clot
SDS
-
enzymatic activity is stimulated 50-100fold by SDS treatment
Sodium azide
-
116% activity at 1 mM (pH 7.0)
additional information
-