1.4.3.13: protein-lysine 6-oxidase

This is an abbreviated version!
For detailed information about protein-lysine 6-oxidase, go to the full flat file.

Reaction

Synonyms

elastin synthetase, LO, LOR2, LOX, LOX-like 2, LOX-like 3, LOX-like protein, LOX-PP, LOXL, LOXL-2, LOXL1, LOXL1 protein, Loxl2, LOXL2a, Loxl3, LOXL3-sv1, LOXL3a, LOXL3b, LOXL4, LOXL5a, LOXL5b, lysyl oxidase, lysyl oxidase 1, lysyl oxidase 3, lysyl oxidase homolog 2, lysyl oxidase like 4, lysyl oxidase like-1, lysyl oxidase like-1 protein, lysyl oxidase propetide, lysyl oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2, lysyl oxidase-like 2a, lysyl oxidase-like 2b, lysyl oxidase-like 3a, lysyl oxidase-like 3b, lysyl oxidase-like 4, lysyl oxidase-like 5a, lysyl oxidase-like 5b, lysyl oxidase-like protein, lysyl oxidase-like1 protein, lysyl oxidases, More, oxidase-like protein 1, PPLO, protein-6-oxidase, protein-L-lysine:oxygen 6-oxidoreductase, protein-lysine 6-oxidase, RAS excision protein, rDmLOXL-1, WS9-14

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.3 With oxygen as acceptor

                1.4.3.13 protein-lysine 6-oxidase

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Results	in table
22	Activating Compound
5964	AA Sequence
20	Application
1	CAS Registry Number
29	Cloned(Commentary)
29	Cofactor
2	Crystallization (Commentary)
4724	Disease/ Diagnostics
12	Expression
41	General Information
6	General Stability
31	IC50 Value
133	Inhibitors
5	KM Value [mM]
44	Localization
44	Metals/Ions
57	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
139	Organism
8	PDB ID
7	pH Optimum
2	pH Range
2	pI Value
22	Posttranslational Modification
27	Protein Variants
18	Purification (Commentary)
8	Reaction
4	Reaction Type
132	Reference
2	Renatured (Commentary)
286	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
137	Substrates and Products (Substrate)
37	Subunits
252	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.4.3.13 - protein-lysine 6-oxidase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000126

(2-chloropyridin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000126

1-(2-chloropyridin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000385

1-(2-fluoropyridin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00118

1-(2-methoxypyridin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000309

1-(2-phenoxypyridin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000431

1-(3-fluoropyridin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.026

1-(4-fluorophenyl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.035

1-(4-methoxyphenyl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000719

1-(4-nitrophenyl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00122

1-(pyridin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00604

1-(quinolin-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000321

1-([2,3'-bipyridin]-4-yl)methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.0647

1-phenylmethanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000203

1-[2-(1H-imidazol-1-yl)pyridin-4-yl]methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000999

1-[2-(trifluoromethyl)pyridin-4-yl]methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00497

1-[3-(hydrazinylmethyl)phenyl]methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000902

1-[4-(1,3-thiazol-2-yl)phenyl]methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00111

1-[4-(hydrazinylmethyl)phenyl]methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.031

1-[5-(trifluoromethyl)[2,3'-bipyridin]-4-yl]methanamine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00821

2-(pyridin-4-yl)ethan-1-amine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.1

2-phenylcyclopropan-1-amine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.0601

2-phenylethan-1-amine

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.1

3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride

Sus scrofa

P45845

-

675286

0.000066

3-aminopropanenitrile

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.1

4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride

Sus scrofa

P45845

-

675286

0.047

4-(aminomethyl)aniline

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00067

4-(aminomethyl)benzonitrile

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.000066

beta-aminopropionitrile

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00354

methyl 3-(aminomethyl)benzoate

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

0.00362

methyl 4-(aminomethyl)benzoate

Homo sapiens

-

LOXL2 protein, at pH 8.0 and 37°C

741494

additional information

additional information

Sus scrofa

P45845

above 1.0 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride and 1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride

675286

-