1.4.3.13: protein-lysine 6-oxidase

This is an abbreviated version!
For detailed information about protein-lysine 6-oxidase, go to the full flat file.

Word Map on EC 1.4.3.13

1.4.3.13

collagen

fibrosis

metastasis

fiber

copper

crosslinking

amine

elastic

glaucoma

aortic

stiff

beta-aminopropionitrile

tropoelastin

copper-dependent

fibril

metalloproteinases

procollagens

biomechanical

propeptide

exfoliation

fibrillar

tensile

myofibroblasts

aneurysm

pseudoexfoliation

cutis

copper-binding

fibrillin-1

open-angle

menkes

copper-deficient

prolapse

fibrillogenesis

cross-linkage

desmosine

copper-containing

medicine

benzylamine

diagnostics

pentosidine

synthesis

microfibrillar

microfibrils

elastosis

ehlers-danlos

elastolytic

col3a1

semicarbazide-sensitive

cuproenzymes

c-proteinase

fibulins

hydroxylysine

pyridinoline

Reaction

Synonyms

elastin synthetase, LO, LOR2, LOX, LOX-like 2, LOX-like 3, LOX-like protein, LOX-PP, LOXL, LOXL-2, LOXL1, LOXL1 protein, Loxl2, LOXL2a, Loxl3, LOXL3-sv1, LOXL3a, LOXL3b, LOXL4, LOXL5a, LOXL5b, lysyl oxidase, lysyl oxidase 1, lysyl oxidase 3, lysyl oxidase homolog 2, lysyl oxidase like 4, lysyl oxidase like-1, lysyl oxidase like-1 protein, lysyl oxidase propetide, lysyl oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2, lysyl oxidase-like 2a, lysyl oxidase-like 2b, lysyl oxidase-like 3a, lysyl oxidase-like 3b, lysyl oxidase-like 4, lysyl oxidase-like 5a, lysyl oxidase-like 5b, lysyl oxidase-like protein, lysyl oxidase-like1 protein, lysyl oxidases, More, oxidase-like protein 1, PPLO, protein-6-oxidase, protein-L-lysine:oxygen 6-oxidoreductase, protein-lysine 6-oxidase, RAS excision protein, rDmLOXL-1, WS9-14

ECTree

1 Oxidoreductases

1.4 Acting on the CH-NH₂ group of donors

1.4.3 With oxygen as acceptor

1.4.3.13 protein-lysine 6-oxidase

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Results	in table
22	Activating Compound
5964	AA Sequence
20	Application
1	CAS Registry Number
29	Cloned(Commentary)
29	Cofactor
2	Crystallization (Commentary)
4724	Disease/ Diagnostics
12	Expression
41	General Information
6	General Stability
31	IC50 Value
133	Inhibitors
5	KM Value [mM]
44	Localization
44	Metals/Ions
57	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
139	Organism
8	PDB ID
7	pH Optimum
2	pH Range
2	pI Value
22	Posttranslational Modification
27	Protein Variants
18	Purification (Commentary)
8	Reaction
4	Reaction Type
132	Reference
2	Renatured (Commentary)
286	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
137	Substrates and Products (Substrate)
37	Subunits
252	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.4.3.13 - protein-lysine 6-oxidase

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5-aza-deoxycytidine

Homo sapiens

activates LOXL2 gene expression

actinomycin D

areca nut extract

up-regulates LOX expression

686141

hypoxia inducible factor-1

Homo sapiens

hypoxia-induced LOX expression is partially mediated by hypoxia inducible factor-1

687920

nuclear factor I-A

Rattus norvegicus

enhances lysyl oxidase promoter activities

687597

nuclear factor I-B

Rattus norvegicus

enhances lysyl oxidase promoter activities

687597

pyridoxal

3 entries

suramin

Homo sapiens

0.15 mM, upregulates LOX expression

685931

transforming growth factor beta

Mus musculus

increases LOX expression and activity

685981

transforming growth factor-beta1

3 entries

tumor growth factor-beta1

Mus musculus

stabilizes LOX mRNA leading to an increase in LOX activity

686366

additional information

6 entries