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1.4.1.9: leucine dehydrogenase

This is an abbreviated version!
For detailed information about leucine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.9

Reaction

L-leucine
+
H2O
 +
NAD+
=
4-methyl-2-oxopentanoate
 +
NH3
 +
NADH
 +
H+

Synonyms

BCD, dehydrogenase, leucine, L-leucine dehydrogenase, L-leucine:NAD+ oxidoreductase, deaminating, LeuDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.9 leucine dehydrogenase

pH Stability

pH Stability on EC 1.4.1.9 - leucine dehydrogenase

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 11
-
purified enzyme, fully stable at 25°C
725737
5.4 - 10.3
-
55°C, 10 min, stable
349681
5.5 - 10
-
55°C, 5 min, stable
349662
5.6 - 9.8
-
25°C, 24 h, maximal loss of 12% of the activity
349661
6 - 10
-
55°C, 10 min, stable
349680
6 - 10.9
-
50°C, 5 min, stable
349685
6 - 11
-
55°C, 10 min, stable
349674
6 - 8
-
-
742375
6.5 - 10.5
-
30 min, 50% loss of activity
349664
7 - 11.2
-
25°C, 30 min, wild-type enzyme and mutant enzymes K80A, K80R and K80Q
349691
7.5
-
70°C, 5 min, most stable at pH 7.5
349685
8 - 11
-
stable for at least 10 h
742176
9.5
-
mutant enzyme LeuDEL4 is stable
656566
9.5 - 10.5
-
native enzyme is stable
656566