1.4.1.9: leucine dehydrogenase
This is an abbreviated version!
For detailed information about leucine dehydrogenase, go to the full flat file.
Word Map on EC 1.4.1.9
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1.4.1.9
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sphaericus
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l-valine
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synthesis
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l-isoleucine
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l-2-aminobutyric
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l-tert-leucine
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intermedius
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thermoactinomyces
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l-threonine
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analysis
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space-time
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3.5.1.5
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trimethylpyruvate
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alpha-ketoisocaproate
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lysinibacillus
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drug development
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biotechnology
- 1.4.1.9
- sphaericus
- l-valine
- synthesis
- l-isoleucine
-
l-2-aminobutyric
- l-tert-leucine
- intermedius
-
thermoactinomyces
- l-threonine
- analysis
-
space-time
-
3.5.1.5
- trimethylpyruvate
- alpha-ketoisocaproate
-
lysinibacillus
- drug development
- biotechnology
Reaction
Synonyms
BCD, dehydrogenase, leucine, L-leucine dehydrogenase, L-leucine:NAD+ oxidoreductase, deaminating, LeuDH
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.4.1.9 - leucine dehydrogenase
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REACTION DIAGRAM
4-methyl-2-oxopentanoate + NH3 + NADH
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the enzyme may have a function in spore germination
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L-Leu + H2O + NAD+
4-methyl-2-oxopentanoate + NH3 + NADH
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the enzyme may have a function in spore germination
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4-methyl-2-oxopentanoate + NH3 + NADH + H+
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L-leucine + H2O + NAD+
4-methyl-2-oxopentanoate + NH3 + NADH + H+
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L-leucine + H2O + NAD+
4-methyl-2-oxopentanoate + NH3 + NADH + H+
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enzyme liberates ammonium ions from branched chain amino acids when supplied as the sole nitrogen source. It synthesizes from L-Ile, L-Leu, L-Val the branched chain alpha-oxo acids which are precursors of branched chain fatty acid biosynthesis
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additional information
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synthesis of (S)-1-cyclopropyl-2-methoxyethanamine starting from methylcyclopropyl ketone. Permanganate oxidation of the ketone gives cyclopropylglyoxylic acid, which is converted to (S)-cyclopropylglycine by reductive amination using leucine dehydrogenase from Thermoactinomyces intermedius with NADH cofactor recycling by formate dehydrogenase from Pichia pastoris
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