1.4.1.7: serine 2-dehydrogenase

This is an abbreviated version!
For detailed information about serine 2-dehydrogenase, go to the full flat file.

Reaction

Synonyms

L-serine:NAD oxidoreductase (deaminating), NAD+-dependent L-serine dehydrogenase, protein PA0743, serine dehydrogenase

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.7 serine 2-dehydrogenase

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Results	in table
1	CAS Registry Number
1	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
1	General Information
1	General Stability
1	Inhibitors
5	kcat/KM [mM/s]
7	KM Value [mM]
3	Natural Substrates/ Products (Substrates)
2	Organism
2	pH Optimum
9	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reaction Type
2	Reference
1	Source Tissue
15	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
5	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.4.1.7 - serine 2-dehydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(R)-3-hydroxyisobutyric acid + H2O + NAD+

? + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

(S)-3-hydroxyisobutyric acid + H2O + NAD+

? + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

3-methyl-DL-serine + H2O + NAD+

2-aminomethylmalonate semialdehyde + NH3 + NADH + H+

Pseudomonas aeruginosa

-

high activity

725474

-

-

?

D-serine + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

DL-glycerate + H2O + NAD+

? + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

L-serine + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH

Petroselinum crispum

-

-

636488

-

-

?

L-serine + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH + H+

2 entries

methyl (R)-3-hydroxy-2-methylpropionic acid + H2O + NAD+

? + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

methyl (S)-3-hydroxy-2-methylpropionic acid + H2O + NAD+

? + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

methyl 2,2-dimethyl-3-hydroxypropionic acid + H2O + NAD+

? + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

tert-butyl 3-hydroxypropionic acid + H2O + NAD+

? + NH3 + NADH + H+

Pseudomonas aeruginosa

-

low activity

725474

-

-

?

additional information

?

-

3 entries

L-serine + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH + H+

Pseudomonas aeruginosa

-

-

725474

-

-

?

L-serine + H2O + NAD+

3-hydroxypyruvate + NH3 + NADH + H+

Pseudomonas aeruginosa

-

best substrate

725474

-

-

?

additional information

?

-

Petroselinum crispum

-

no substrates in presence of NADH: alpha-ketoglutarate, oxaloacetate, glyoxylate, or pyruvate

636488

-

-

?

additional information

?

-

Pseudomonas aeruginosa

-

PA0743 from Pseudomonas aeruginosa catalyzes NAD-dependent oxidation of L-serine and methyl-L-serine, and exhibits low activity against beta-hydroxyisobutyrate

725474

-

-

?

additional information

?

-

Pseudomonas aeruginosa

-

substrate specificity, overview. No activity with (S)-beta-hydroxybutyric acid, (R)-3-hydroxybutyric acid, 2-hydroxyisobutyric acid, methyl-2-hydroxyisobutyric acid, ethyl-2-hydroxyisobutyric acid, 2-hydroxybutyric acid, DL-malic acid, and DL-homoserine

725474

-

-

?