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1.4.1.4: glutamate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glutamate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.4.1.4

Reaction

L-glutamate
+
H2O
+
NADP+
=
2-oxoglutarate
+
NH3
+
NADPH
+
H+

Synonyms

APE1386, BpNADPGDH I, BpNADPGDH II, dehydrogenase, glutamate (nicotinamide adenine dinucleotide phosphate), EcGDH, GDH, GDH1, Gdh1p, GDH2, GDH3, Gdh3p, GDH4, GdhA, GDHB, GDHC, GDHI, GDHI', GDHII, GDHP, GluDH, glutamate dehydrogenase, glutamate dehydrogenase 1, glutamate dehydrogenase 2, glutamate dehydrogenase 3, glutamic acid dehydrogenase, glutamic dehydrogenase, GW612_14215, H-form specific BpNADPGDH II, hGDH, hyphal-form specific BpNADPGDH II, L-glutamate dehydrogenase, NAD(P)H-dependent glutamate dehydrogenase, NADP(+)-dependent glutamate dehydrogenase, NADP(H)-dependent glutamate dehydrogenase, NADP(H)-GDH, NADP(H)-specific glutamate dehydrogenase, NADP+ - dependant-glutamate dehydrogenase, NADP+-dependent GDH, NADP+-dependent glutamate dehydrogenase, NADP+-Gdh, NADP-dependent GDH, NADP-dependent GluDH, NADP-dependent glutamate dehydrogenase, NADP-dependent glutamate dehydrogenase 1, NADP-dependent glutamate dehydrogenase 2, NADP-GDH, NADP-GDH 1, NADP-GDH 2, NADP-glutamate dehydrogenase, NADP-linked glutamate dehydrogenase, NADP-specific glutamate dehydrogenase, NADP-specific L-glutamate dehydrogenase, NADP-ylGdh1p, NADPH-dependent GDH, NADPH-dependent glutamate dehydrogenase, OsGDH4, Pcal_1606, RocG, TrGDH, Y-form specific BpNADPGDH I, YALI0F17820g, yeast-form specific BpNADPGDH I, ylGDH1

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.4 glutamate dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.4.1.4 - glutamate dehydrogenase (NADP+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.029 - 0.059
-
pH 8.2, 30°C
0.29
-
host human adult, reductive amination at 30°C and pH 6.5
0.31
-
host human infant, reductive amination at 30°C and pH 6.5
0.33
-
wild-type EcGDH using NAD+ as coenzyme
0.34
-
host chicken, reductive amination at 30°C and pH 6.5
0.37
-
crude extract
0.4
-
reductive amination at 30°C and pH 6.5
0.45
-
host calf, reductive amination at 30°C and pH 6.5
0.49
-
chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH using NAD+ as coenzyme
0.59
-
host rat, reductive amination at 30°C and pH 6.5
0.62
-
strain parvolorum, reductive amination at 30°C and pH 6.5
0.8
-
strain liberorum, reductive amination at 30°C and pH 6.5
1.1
-
strain breve a, reductive amination at 30°C and pH 6.5
1.16
-
strain infantis a, reductive amination at 30°C and pH 6.5
1.68
-
oxidative deamination
10.3
-
oxidative deamination at 50°C and pH 8.2
10.92
-
reductive amination
1140
-
reductive amination at pH 7.5 and 60°C
121
-
reductive amination at 30°C
133
-
reductive amination at 37°C and pH 6.7
18.4
-
oxidative deamination at 25°C
180
-
oxidative deamination at 25°C
194.3
-
oxidative deamination at 75°C
2.17
-
crude extract
2.54
-
reductive amination
204.1
-
oxidative deamination at 20°C
231
-
oxidative deamination at 25°C
24.3
-
oxidative deamination at 50°C and pH 8.2
250
-
oxidative deamination
28
amination, pH 8.0, 25°C, recombinant enzyme
2940
-
reductive amination at 80°C and pH 7.54
32.8
-
pH 9.0, 50°C
32.9
-
reductive amination at 30°C
36.5
-
after 7.4fold purification, at 25°C in 0.1 M potassium phosphate containing 100 mM L-glutamate and 0.5 mM NADP+ at pH 8
3802.7
-
pH not specified in the publication, 30°C
388
-
reductive amination
4
deamination, pH 8.0, 25°C, recombinant enzyme
4.9
-
unpurified supernatant, at 25°C in 0.1 M potassium phosphate containing 100 mM L-glutamate and 0.5 mM NADP+ at pH 8
40
-
T138E-mutant
416
-
reductive amination at 30°C
46.2
Thermophilic bacillus
-
reductive amination at 55°C
464
-
oxidative deamination at 80°C and pH 7.54
5.2
pH 8.3, 50°C
5.64
strain DPPMA49, pH 8.0, 37°C, comparison to activity in diverse other DPPMA strains of Lactobacillus plantarum and to other Lactobacilli, overview
51.2
-
reductive amination
57.6
-
reductive amination
58
-
chimeric protein CEC consisting of the substrate-binding domain of CsGDH and the coenzyme-binding domain of Escherichia coli GDH using NADP+ as coenzyme
59.4
-
purified enzyme
61
amination, pH 8.0, 25°C, recombinant enzyme
63
-
wild-type EcGDH using NADP+ as coenzyme
631
-
pH 8.0, 23°C
7
-
purified enzyme
74.5
-
oxidative deamination at pH 7.0 and 70°C
78
-
reductive amination at 20°C
8.2
-
reductive amination at 33°C
80
-
E158Q-mutant
80.2
-
reductive amination
85
-
oxidative deamination at 80°C and pH 8.0
9
deamination, pH 8.0, 25°C, recombinant enzyme
9.2
-
reductive amination
930
-
reductive amination at 37°C
additional information