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1.4.1.2: glutamate dehydrogenase

This is an abbreviated version!
For detailed information about glutamate dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.2

Reaction

L-glutamate
+
H2O
+
NAD+
=
2-oxoglutarate
+
NH3
+
NADH
+
H+

Synonyms

At5g18170, AtGDH1, BpNADGDH, c, CCNA_00086, CsGDH, dehydrogenase, glutamate, GDH, GDH isoenzyme 1, GDH, NAD-dependent, gdh-1, gdh-2, GDH1, GDH2, Gdh2p, GDH3, GdhA, GDHB, GDHI, GdhZ, Glu dehydrogenase, GluD, GLUD1, GLUD2, GluDH, glutamate dehydrogenase, glutamate dehydrogenase (NAD), glutamate dehydrogenase 2, glutamate dehydrogenase alpha subunit, glutamate dehydrogenase beta subunit, glutamate dehydrogenase isoform 1, glutamate oxidoreductase, glutamic acid dehydrogenase, glutamic dehydrogenase, hGDH1, hGDH2-nerve-specific GDH, house-keeping GDH, L-glutamate dehydrogenase, L-glutamic acid dehydrogenase, More, NAD(+)-dependent glutamate dehydrogenase, NAD(H)-dependent glutamate dehydrogenase, NAD+-dependant glutamate dehydrogenase, NAD+-dependent GDH, NAD+-dependent GDHX, NAD+-dependent GluDH, NAD+-dependent glutamate dehydrogenase, NAD+-GDH, NAD+-glutamate dehydrogenase, NAD+-specific GDH, NAD+-specific glutamate dehydrogenase, NAD-dependent GDH, NAD-dependent glutamate dehydrogenase, NAD-dependent glutamic dehydrogenase, NAD-dependent L-glutamate dehydrogenase, NAD-GDH, NAD-glutamate dehydrogenase, NAD-linked glutamate dehydrogenase, NAD-linked glutamic dehydrogenase, NAD-specific glutamate dehydrogenase, NAD-specific glutamic dehydrogenase, NAD-ylGdh2p, NAD:glutamate oxidoreductase, NADH-dependent GDH, NADH-dependent glutamate dehydrogenase, NADH-GDH, NADH-glutamate dehydrogenase, NADH-linked glutamate dehydrogenase, OsGDH1, OsGDH2, OsGDH3, Pcal_1031, RocG, sco2999, Surface-associated protein PGAG1, t-GDH, type I GDH, YALI0E09603g, ylGDH2

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.2 glutamate dehydrogenase

Expression

Expression on EC 1.4.1.2 - glutamate dehydrogenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is upregulated under N2-starvation, overview
expression of Gdh2-GFP is repressed by glucose and decreases as the pH of the media approaches neutrality
Gdh2-GFP (cytoplasm) expression is induced similar to Put2-GFP (mitochondria) in cells engulfed by RAW-264.7 macrophages
in the presence of preferred nitrogen sources, the expression of GDH2 is repressed by the transcriptional regulator Ure2 which sequesters Gln3 into the cytoplasm. The expression of GDH2 is regulated by the concurrent action of Gcn4 and Gln3. These two regulatory networks have been thought to interact, putting forward the existence of a physiological relation between Gln3 and Gcn4. Under nitrogen derepressive conditions and amino acid deprivation, Gcn4 and Gln3 form part of a transcriptional complex that binds on GDH2 promoter and dictates its expression. Overexpression of GDH2 is favoring yeast growth providing a growth advantage
replacement of ammonia with glutamate in growth medium causes an increase in NAD-ylGdh2p activity
transcription of GDH2, which encodes the GDH alpha subunit, is activated and translation of the GDH2 mRNA is also activated to synthesize a subunit polypeptides, when protoplasts are isolated. When detached leaves absorb either acidic 5 mM jasmonic acid or salicylic acid solutions via petioles, GDH7 isoenzyme is activated and the GDH isoenzyme expression pattern is similar to that of protoplasts
-
under nitrogen- and phosphorus-deficient conditions, respectively: In shoots, OsGDH2 is dramatically induced after nitorgen-deprivation for 1 day, with 5.4fold increase, respectively. Its expression increases greatly after 7 days of phosphorus-deprivation
-
under nitrogen- and phosphorus-deficient conditions, respectively: In shoots, OsGDH3 is dramatically induced after nitorgen-deprivation for 1 day, with 9.7fold increase, respectively. OsGDH3 expression is also up-regulated by 3.1fold after phosphorus-deprivation for 7 days. OsGDH3 transcript is undetectable under the normal conditions in roots, and increases by 7.6fold after phosphorus-deprivation for 1 day
-
under nitrogen- and phosphorus-deficient conditions, respectively: OsGDH2 expression is largely reduced by both nitrogen- and phosphorus-deprivation after 1 h
-